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2019 | 79 | 2 |

Tytuł artykułu

The effects of moderate running exercise and L‑tyrosine on penicillin‑induced epileptiform activity in rats

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Regular exercise and amino acid supplementation, popular approaches toward the reduction of epileptic seizures, have been extensively researched. This study was conducted to evaluate the effects of treadmill exercise and L-tyrosine treatment on the frequency and amplitude of epileptiform activity in rats. A total of 32 male albino Wistar rats were randomly divided into four groups: control, exercise, L-tyrosine, and exercise + L-tyrosine. L-tyrosine was supplemented by oral gavage (500 mg/kg/day, 2.5 mL solution). The treatments were performed 5 days a week for 10 weeks. The rats were anesthetized and then administered 500 IU penicillin into the left cerebral cortex using a microinjector and electrocorticogram (ECoG) activity was recorded for 3 hours using a Power Lab data acquisition system. The frequency and the amplitude of the ECoG recordings were analyzed offline. Compared to the control group, spike frequency decreased significantly in all other groups. There was no statistically significant difference between the groups in terms of spike amplitude and latency. In this study, the effects of regularly administered treadmill exercise and L-tyrosine use on epileptiform activity were examined and evaluated together for the first time. The results of this study showed that regular exercise and L-tyrosine use decreased epileptiform activity. Further research and clinical trials are needed to investigate the extent to which L-tyrosine and physical activity interfere with the epileptic state by investigating different doses of L-tyrosine and different severity/ time/type of exercise protocols.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

79

Numer

2

Opis fizyczny

p.148-154,fig.,ref.

Twórcy

autor
  • Faculty of Yasar Dogu Sports Sciences, Ondokuz Mayıs University, Samsun, Turkey
autor
  • Faculty of Yasar Dogu Sports Sciences, Ondokuz Mayıs University, Samsun, Turkey
  • Faculty of Yasar Dogu Sports Sciences, Ondokuz Mayıs University, Samsun, Turkey
autor
  • Health Care Vocational High School, Ondokuz Mayıs University, Samsun, Turkey
autor
  • Department of Physiology of Medicine, Ondokuz Mayıs University, Samsun, Turkey
autor
  • Department of Physiology of Medicine, Ondokuz Mayıs University, Samsun, Turkey

Bibliografia

  • Alcantara JA, Vincentis S, Kerr DS, dos Santos B, Alessi R, van der Linden HT, Chaim MH, Serpa GF, Busatto WF, Gattaz R, Demarque KD, Valente (2018) Association study of functional polymorphisms of dopaminergic pathway in epilepsy-related factors of temporal lobe epilepsy in Brazilian population. Eur J Neurol 25: 895–901.
  • Allendorfer JB, Arida RM (2018) Role of physical activity and exercise in alleviating cognitive impairment in people with epilepsy. Clin Ther 40: 26–34.
  • Arslan G, Alici SK, Ayyildiz M, Agar E (2013) The Role of CB 1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats. CNS Neurosci Ther 19: 222–228.
  • Avloniti A, Chatzinikolaou A, Deli CK, Vlachopoulos D, Gracia-Marco L, Leontsini D, Fatouros IG (2017) Exercise-induced oxidative stress responses in the pediatric population. Antioxidants 6: pii E6.Bozzi Y, Dunleavy M, Henshall DC (2011) Cell signaling underlying epileptic behavior. Front Behav Neurosci 5: 45.
  • Bozzi Y, Borrelli E (2013) The role of dopamine signaling in epileptogenesis. Front Cell Neur 7: 157.
  • Chatrian GE, Bergamini L, Dondey M, Klass DW, Lennox-Buchtal M, Petersen I (1974) A glossary of terms most commonly used by electroencehalographers. Electroencephalgr Clin Neuropysiol 37: 538–548.
  • Chinevere TD, Sawyer RD, Creer AR, Conlee RK (2002) Effects of l-tyrosine and carbohydrate ingestion on endurance exercise performance. J Appl Physiol 93: 1590–1597.
  • Coull NA, Watkins SL, Aldous JWF, Warren LK, Chrismas BC, Dascombe B, Taylor L (2015) Effect of tyrosine ingestion on cognitive and physical performance utilising an intermittent soccer performance test (iSPT) in a warm environment. Eur J Appl Physiol 115: 373–386.
  • Çakır S, Orallar H, Cetinkaya A, Kayacan Y, Önal AC, Yildirim A, Okur N (2016) Ameliorating effect of hawthorn (Crataegus oxyacantha) and physical exercise on acute penicillin induced seizures in gerbils. Afr J Tradit Complement Altern Med 13: 223–228.
  • Depaulis A, Vergnes M, Marescaux C (1994) Endogenous control of epilepsy: the nigral inhibitory system. Prog Neurobiol 421: 33–52.
  • Erfanparast A, Tamaddonfard E (2015) Effects of intracortical microinjection of vitamin B12 on penicillin-induced epileptiform activity in rats. Acta Neurobiol Exp 752: 200–207.
  • Evans LW, Omaye ST (2017) Use of saliva biomarkers to monitör efficacy of vitamin C in exercise-induced oxidative stress. Antioxidants 6: 5.
  • Fenstrom JD (2005) Branced-chain amino acids and brain function. J Nutr 135: 1539–1546.
  • Gemili S, Yemenicioglu A, Altınkaya SA (2010) Development of antioxidant food packaging materials with controlled release properties. J Food Eng 96: 325–332.
  • Häfele CA, Freitas MP, Gervini BL, De Carvalho RM, Rombaldi AJ (2018) Who are the individuals diagnosed with epilepsy using the Public Health System in the city of Pelotas, southern Brazil. Epilepsy Behav 78: 84–90.
  • Hansen N, Manahan-Vaughan D (2014) Dopamine D1/D5 receptors mediate informational saliency that promotes persistent hippocampal long-term plasticity. Cereb Cortex 24: 845–858.
  • Hasegawa H, Takatsu S, Ishiwata T, Tanaka H, Sarre S, Meeusen R (2011) Continuous monitoring of hypothalamic neurotransmitters and thermoregulatory responses in exercising rats. J Neurosci Methods 202: 119–123.
  • Hattori S, Naoi M, Nishino H (1994) Striatal dopamine turnover during treadmill running in the rat: relation to the speed of running. Brain Res Bull 35: 41–49.
  • Hoffman JR, Kang J, Ratamess NA, Hoffman MW, Tranchina CP, Faigenbaum AD (2009) Examination of a pre-exercise, high energy supplement on exercise performance. J Int Soc Sports Nutr 6: 2.
  • Kayacan Y, Bahadir A, Cetinkaya A, Orallar H, Cakir S, Beyazcicek E, Yildirim A (2016) Penicillin-Induced Epileptiform ECoG Activity in Gerbils: Effects of Physical Exercise and a Diospyros kaki Extract. Neurophysiology 48: 367–374.
  • Kayacan Y, Yazar H, Kisa EC, Ghojebeigloo BE (2017) A novel biomarker explaining the role of oxidative stress in exercise and l-tyrosine supplementation: thiol/disulphide homeostasis. Arch Physiol Biochem 1: 5.
  • Kayacan Y, Yazar H, Cerit G, Ghojebeigloo BE (2019) A new oxidative stress indicator: Effect of 5-hydroxytryptophan on thiol disulfide homeostasis in exercise. Nutrition https: //doi.org/10.1016/j.nut.2019.01.013
  • Kim HJ, Kim IK, Song W, Lee J, Park S (2013) The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice. Neurochem Res 38: 117–122.
  • McLeay Y, Stannard S, Houltham S, Starck C (2017) Dietary thiols in exercise: oxidative stress defence, exercise performance, and adaptation. J Int Soc Sports Nutr 14: 12.
  • Patel M (2004) Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures. Free Radic Biol Med 12: 1951–1962.
  • Rezaei M, Sadeghian A, Roohi N, Shojaei A, Mirnajafi-Zadeh J (2017) Epilepsy and dopaminergic system. Physiol Pharmacol 21: 1–14.
  • Robertson CL, Ishibashi K, Chudzynski J, Mooney LJ, Rawson RA, Dolezal BA, London ED (2016) Effect of exercise training on striatal dopamine D2/D3 receptors in methamphetamine users during behavioral treatment. Neuropsychopharmacology 41: 1629–1636.
  • Sari-Sarraf V, Amirsasan R, Zolfi HR (2016) Effects of aerobic and exhaustive exercise on salivary and serum total antioxidant capacity and lipid peroxidation indicators in sedentary men. Feyz Journal of Kashan University of Medical Sciences 20: 427–434.
  • Shi K, Liu X, Qiao D, Hou L (2017) Effects of treadmill exercise on spontaneous firing activities of striatal neurons in a rat model of Parkinson’s disease. Motor Control 21: 58–71.
  • Souza MA, Oliveira MS, Furian AF, Rambo LM, Ribeiro LR, Lima FD, Puntel GO (2009) Swimming training prevents pentylenetetrazol-induced inhibition of Na+, K+-ATPase activity, seizures, and oxidative stress. Epilepsia 504: 811–823.
  • Starr MS (1996) The role of dopamine in epilepsy. Synapse 22: 159–194.
  • Steenbergen L, Sellaro R, Hommel B, Colzato LS (2015) Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance. Neuropsychologia 69: 50–55.
  • Sumien N (2017) Interactions of antioxidant supplementation and moderate exercise on brain function. Exp Gerontol 94: 122–123.
  • Sutton EE, Coill MR, Deuster PA (2005) Ingestion of tyrosine: effects on endurance, muscle strength, and anaerobic performance. Int J Sport Nutr Exerc Metab 15: 173–185.
  • Şentürk UK, Gündüz F, Kuru O, Aktekin MR, Kipmen D, Yalçin O, Başkurt OK (2001) Exercise-induced oxidative stress affects erythrocytes in sedentary rats but not exercise-trained rats. J Appl Physiol 91: 1999–2004.
  • Tchekalarova J, Loyens E, Smolders I (2015) Effects of AT 1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats. Epilepsy Behav 46: 66–71.
  • Tokiwa T, Zimin L, Inoue T, Nomura S, Suzuki M, Yamakawa T (2018) Detailed spectral profile analysis of electrocorticograms during freezing against penicillin-induced epileptiform discharges in the anesthetized rat. Epilepsy Res 143: 27–32.
  • Tumilty L, Davison G, Beckmann M, Thatcher R (2011) Oral tyrosine supplementation improves exercise capacity in the heat. Eur J Appl Physiol 111: 2941–2950.
  • Yang H, Zhang X (2017) Polysaccharides from polygonatum odoratum strengthen antioxidant defense system and attenuate lipid peroxidation against exhaustive exercise-induced oxidative stress in mice. Trop J Pharm Res 16: 795–801.
  • Yoon MC, Shin MS, Kim TS, Kim BK, Ko IG, Sung YH, Kim CJ (2007) Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson’s rats. Neurosci Lett 423: 12–17.
  • Zhu X, Chen Y, Du Y, Wan Q, Xu Y, Wu J (2018) Astragaloside IV attenuates penicillin-induced epilepsy via inhibiting activation of the MAPK signaling pathway. Mol Med Rep 17: 643–647.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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