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2015 | 18 | 3 |
Tytuł artykułu

Tumor necrosis factor - alpha (TNFalpha) gene polymorphism and expression of membrane - bound TNFalpha protein on CD11bplus and IgMplus cells in cows naturally infected with bovine leukemia virus

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of this study was to determine whether SNP at position -824 (promoter region) of the TNFα gene significantly differentiates the size of IgM+, CD5+ and CD11b+ cell subpopulations and affects the expression of membrane-bound TNFα protein (mTNFα) on these cells and their susceptibility to BLV infections. In this study, significant differences were determined for the first time between TNFα genotypes and the percentage of cells with the CD11b+TNFα+p24+ immunophenotype. Furthermore, greater expansion of lymphocytes with the IgM+TNFα+p24+ immunophenotype was reported in cows with the G/G genotype than in A/A homozygotes. Cells with the above immunophenotype were more frequently observed in cows with persistent leukocytosis than in aleukemic cattle. Our results suggest that polymorphism of the TNFα -824 A>G gene and mTNFα protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
18
Numer
3
Opis fizyczny
p.533-539,ref.
Twórcy
  • Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland
  • Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland
autor
  • Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland
autor
  • Department of Animal Genetics, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland
Bibliografia
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  • Kaczmarczyk E, Fiedorowicz A, Bojarojć-Nosowicz B, Majewski M (2004) Profile of peripheral blood lymphocytes in the first months of life of heifers originating from a leukaemic herd. Bull Vet Inst Pulawy 48: 361-366.
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Typ dokumentu
Bibliografia
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