Influence of aflatoxin B1 on oxidoreductive balance in renal tissue of rats

• Autorzy: Wojtowicz-Chomicz K. , Stadnik A. , Huk-Wieliczuk E. , Czeczuk A. , Borzecki A.
• Języki publikacji: EN

Abstrakty

EN

The toxic effect of various doses of aflatoxin B₁ on renal function was studied. Experiments were conducted on randomly chosen Wistar rats. The animals were divided into four groups. Group 1 received 8% alcohol intragastrically. The other groups received aflatoxin B₁ in various doses. The effect of the aflatoxin on renal cells was analysed by means of determination of oxidoreductive balance and development of free radicals. The activity of antioxidative enzymes in renal tissue has decreased with an increase in the dose of aflatoxin B₁. Disturbance of oxidation balance in the kidneys confirm a toxic effect of aflatoxin B₁ on these organs.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2013
• Tom: 57
• Numer: 1
• Opis fizyczny: p.103-116,fig.,ref.

Twórcy

autor

Wojtowicz-Chomicz K.

• Department of Health Promotion, Faculty of Physical Education and Sport in Biała Podlaska, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland

autor

Stadnik A.

• Department of Cardiac Surgery, Medical University of Lublin, 20-954 Lublin, Poland

autor

Huk-Wieliczuk E.

• Department of Health Promotion, Faculty of Physical Education and Sport in Biała Podlaska, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland

autor

Czeczuk A.

• Department of Health Promotion, Faculty of Physical Education and Sport in Biała Podlaska, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland

autor

Borzecki A.

• Chair and Department of Hygiene, Medical University of Lublin, 20-080 Lublin, Poland

Bibliografia

• 1. Arthur J.R., Boyne R.: Superoxide dismutase and glutathione peroxidase activities in neutrophils from
• 2. Bartosz G.: Second face of the oxygen. Ed. PWN, Warsaw, 2003.
• 3. Bennett J.W., Klich M.: Mycotoxins Clin Microbiol Rev 2003, 497-516.
• 4. Bhatnagar D., Yu J., Ehrlich K.C.: Toxins of filamentous fungi. Chem Immunol 2002, 81, 167-206.
• 5. Bonnefoy M., Drai J., Kostka T.: Antioxidants to slow aging, facts and perspectives Presse Med 2002, 31, 1174- 1184.
• 6. Choudhary A., Verma R.J.: Black tea ameliorates aflatoxin - inducted lipid peroxidation in the kidney of mice. Acta Pol Pharm 2006, 63, 307-310.
• 7. Laciakova A., Ciconova P., Mate D., Laciak V.: Anatoxins and possibilities for their biological detoxification. Med Weter 2008, 64, 276-279.
• 8. Mathuria N., Verma R.J.: Curcumin ameliorates aflatoxin - induced lipid peroxidation in liver, kidney and testis of mice - in vitro study. Acta Pol Pharm 2007, 63, 413-416.
• 9. Abel-Wahhab M.A., Said A., Heufner A.: NMR and radical scavering activities of patuletin from Utrica urens aganist aflatoxin B₁. Pharm Biology 2005, 43, 515-525.
• 10. Obremski K., Zielonka L., Gajęcka M., Jakimiuk E., Gajęcki M.: Mycotoxins - dain cattle breeding problem. A case report. Bull Vet Inst Pulawy 2009, 53, 221-224.
• 11. Paglia D.E., Valentine W.N.: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967, 70, 158- Ï69.
• 12. Palance T., Dutton M., Chuturgoon A.A.: Cytoxicity of aflatoxin B₁ and its chemically synthesized epoxide derivative on the A5449 human epithelial cell lines. Mycopathology 2000, 151, 155-159.
• 13. Rastogi R., Srivastava A.K., Rastogi A.K.: Long term effect of aflatoxin B₁ on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin. Phytoter Res 2001, 15, 307-310.
• 14. Stec J., Szczotka M., Kuźmak K., Cytotoxicity of free- borne mycotoxins to animal cell lines in vitro using the MTT assay. Bull Vet Inst Pulawy 2007, 51, 679-684.
• 15. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J.: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2006, 39, 44-84.
• 16. Vrabcheva T.M.: Mycotoxins in spices. Vopr Pitan 2000, 69, 40-43.
• 17. Wilson D.M., Mubatanhema W., Jurjevic Z.: Biology and ecology of mycotoxigenic Aspergillus species as related to economic heatlh concerns. Adv Exp Med Biol 2002, 504, 1-17.

Identyfikatory

DOI

10.2478/bvip-2013-0019