Immunomodulatory effect of beta-glucan on peritoneal macrophages of Babl/c mice

• Autorzy: Roudbary M. , Daneshmandi S. , Hajimoradi M. , Roudbarmohammadi S. , Hassan Z.M.
• Języki publikacji: EN

Abstrakty

EN

We assessed the effect of β-Glucan on macrophages by Griess reagent and viability by MTT assay and cytotoxicity. Assay of macrophages culture supernatants were carried out on WEHI-164 fibrosarcoma cell line as tumor necrosis factor-α bioassay were done. NO release was increased at the dose of 10 μg/ml (P=0.001) of β-Glucan while the viability of macrophages in all concentrations was the same. In TNF-α bioassay, the supernatant of macrophages stimulated with β-Glucan had a significant cytotoxic effect on WEHI-164 cells (P=0.023). β-Glucan had a positive effect on increasing tumoricidal activity of macrophages which may help in anti-cancer immune responses.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2015
• Tom: 64
• Numer: 2
• Opis fizyczny: p.175-179,fig.,ref.

Twórcy

autor

Roudbary M.

• Department of Mycology and Parasitology, School of Medicine, Iran university of Medical Science, Tehran, Iran

autor

Daneshmandi S.

• Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

autor

Hajimoradi M.

• Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

autor

Roudbarmohammadi S.

• Department of Mycology and Parasitology, School of Medicine, Iran University of Medical Science, Tehran, Iran

autor

Hassan Z.M.

• Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

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