Magnetic resonance assessment of the hippocampal volume in canine idiopathic epilepsy as a possible model for human mesial temporal lobe epilepsy

• Autorzy: Czerwik A. , Plonek M. , Nicpon J. , Wrzosek M.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: Idiopathic epilepsy (IE) is one of the most common neurological diseases in humans and dogs. In humans the most frequent form is mesial temporal lobe epilepsy (mesial TLE) and is characterised by hippocampal sclerosis (HS). Hippocampal atrophy and/ or necrosis in IE dogs may be equivalent to HS, but TLE is yet not diagnosed in dogs. AIM(S): The aim of the study was the magnetic resonance comparison of the volume of the hippocampus dogs with IE with healthy group. METHOD(S): The study was carried on 18 dogs, divided into groups: A, dogs with confirmed IE (n=9, 6 males, 3 females, mean age 65 months [range 8–108]) and B; dogs with no history of seizures, normal blood and brain MRI (n=9, 7 males, 2 females, mean age 88 months [range 36–120]). All dogs underwent brain MRI (1.5T, Philips, Ingenia). The results were calculated using MR slice volumetric (cm3 ) analysis of the right and left hippocampus (OsiriX 8, Switzerland), using a semi-automatic method (T2W transverse images, TR/TE 6032/100 ms, FOV 140 mm, layer thickness 3.00 mm, GAP 1.0 mm, voxel size 0.45/0.58/2.00 mm). Statistical analysis was carried out using Statistica software (version 12.5). Data distribution was assessed using the Shapiro-Wilk test. Normally distributed data was assessed using the Student’s t-test. Non-normally distributed data was assessed using Mann-Whitney U test. Statistical significance was set at p<0.05. RESULTS: There was a statistically significant difference in the size of the left and right hippocampus between group A and B (left p=0.001, right p=0.007). No difference was found in the inter hemispheric volumes of the hippocampus in both groups (p>0.05). CONCLUSIONS: We found significant differences in the hippocampal volume in IE dogs visible in MRI, suggesting hippocampal atrophy. This finding may resemble human mesial TLE, which makes tdogs a possible naturally occurring animal model for human mesial TLE.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.70

Twórcy

autor

Czerwik A.

• University of Environmental and Life Sciences, The Faculty of Veterinary Medicine, Department of Internal Medicine and Clinic for Horses, Dogs and Cats, Wroclaw, Poland

autor

Plonek M.

• University of Environmental and Life Sciences, The Faculty of Veterinary Medicine, Department of Internal Medicine and Clinic for Horses, Dogs and Cats, Wroclaw, Poland

autor

Nicpon J.

• University of Environmental and Life Sciences, The Faculty of Veterinary Medicine, Center of Experimental Diagnostics and Innovative Biomedical Technologie, Wroclaw, Poland

autor

Wrzosek M.

• University of Environmental and Life Sciences, The Faculty of Veterinary Medicine, Department of Internal Medicine and Clinic for Horses, Dogs and Cats, Wroclaw, Poland