Effects of bupropion on the reinstatement of nicotine-conditioned place preference by drug priming in rats

• Autorzy: Budzynska B. , Biala G. , Kruk M.
• Języki publikacji: EN

Abstrakty

EN

A common element in the phenomenon of addiction is polydrug abuse. Behavioural responses related to the relapse to drug taking can be measured in various animal models e.g., in the conditioned place preference (CPP) paradigm. In the present experiments, we employed CPP paradigm including the establishment, extinction, reinstatement and cross-reinstatement procedures, to study mechanisms of nicotine seeking behaviour and interactions between nicotine and cannabinoids and ethanol. First, we revealed that nicotine produced a place preference to the initially less-preferred compartment paired with its injections during conditioning (0.175 mg/kg, base, i.p.). Once established, nicotine CPP was extinguished by repeated testing. Following this extinction phase, nicotineexperienced rats were challenged with CB1 receptor agonist – WIN 55,212-2 (0.5 mg/kg, i.p.) or ethanol (0.5 g/kg, i.p.). These priming injections of both drugs reinstated a marked preference for the compartment previously paired with nicotine. Furthermore, we evaluated the efficacy of atypical antidepressant drug - bupropion (5, 10 and 20 mg/kg, i.p.) in blocking reinstatement of nicotine CPP provoked by WIN 55,212-2 and ethanol. Our results demonstrated that bupropion (exept for dose 10 mg/kg used in reinstatement induced by WIN 55,212-2) attenuated the reinstatement of nicotine-conditioned response induced by both drugs. Results obtained in the present studies may contribute to better understanding of the neurochemical mechanisms underlying nicotine addiction and reciprocal relationships between nicotine, cannabis and ethanol. As reinstatement of drug-seeking is a factor for the development of dependence, bupropion may be useful in the relapse-prevention phase of addiction treatment.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.65

Twórcy

autor

Budzynska B.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Biala G.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

autor

Kruk M.

• Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland

Uwagi

Rekord w opracowaniu