The human ether-a’-go-go related gene (hERG) Kplus channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues

• Autorzy: Alexandrou A.J. , Milnes J.T. , Sun S.Z. , Fermini B. , Kim S.C. , Jenkinson S. , Leishman D.J. , Witchel H.J. , Hancox J.C. , Leaney J.
• Języki publikacji: EN

Abstrakty

EN

Słowa kluczowe

EN

human ether-a-go-go-related gene; long QT syndrome; L-type calcium channel; human embryonic kidney; H9c2 cell

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2014
• Tom: 65
• Numer: 4
• Opis fizyczny: p.511-523,fig.,ref.

Twórcy

autor

Alexandrou A.J.

• Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, U.K.

autor

Milnes J.T.

• School of Physiology and Pharmacolology, and Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol, BS8 1TD, U.K.
• Xention Ltd, Iconix Park, London Road, Pampisford, Cambridge, CB22 3EG, U.K.

autor

Sun S.Z.

• Pfizer Inc., Global Safety Pharmacology, Eastern Point Road, MS 8274-1347, USA

autor

Fermini B.

• Pfizer Inc., Global Safety Pharmacology, Eastern Point Road, MS 8274-1347, USA

autor

Kim S.C.

• Pfizer Inc., Global Safety Pharmacology, Eastern Point Road, MS 8274-1347, USA

autor

Jenkinson S.

• Pfizer Inc., Global Safety Pharmacology, San Diego, CA 92121, USA

autor

Leishman D.J.

• Lilly Research Laboratories, Indianapolis IN 46285, USA

autor

Witchel H.J.

• School of Physiology and Pharmacolology, and Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol, BS8 1TD, U.K.
• Brighton and Sussex Medical School, University of Sussex, Falmer BN1 9PX, U.K.

autor

Hancox J.C.

• School of Physiology and Pharmacology, and Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol, BS8 1TD, U.K.

autor

Leaney J.

• Discovery Park House, Ramsgate Road, Sandwich, Kent, Kent, CT13 9NJ, U.K.