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2011 | 55 | 4 |

Tytuł artykułu

Concentration of cefacetril in milk after its intramammary administration to cows with healthy and inflammed mammary gland

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the study was to develop a sensitive analytical method that enables to determine cefacetril concentration in milk after its application to the udders, as well as to establish and compare cefacetril’s basic pharmacokinetic indicators after its intramammary application to cows with inflammed and healthy udders. The content of cefacetril was determined with the use of high-performance liquid chromatography with UV detection. Usefulness of the developed analytical method in the studies of pharmacokinetics of cefacetril has been demonstrated. Results obtained during the statistical analysis and bacteriological examinations allowed to regard the antibiotic as an accurately selected medical product used in the treatment of mastitis in cows.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

55

Numer

4

Opis fizyczny

p.685-688,ref.

Twórcy

  • Sub-Department of Pharmacology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland
autor
autor
autor

Bibliografia

  • 1. Anon: Cefacetrile Summary Report (1). Committee for Veterinary Medicinal Products EMEA/MRL/499/98-Final, London, September 1998.
  • 2. Anon: Cefacetrile Summary Report (2). Committee for Veterinary Medicinal Products EMEA/MRL/754/00-Final, London, July 2000.
  • 3. Anon: Cefacetrile Summary Report (3). Committee for Veterinary Medicinal Products EMEA/MRL/784/01-Final, London, May 2001.
  • 4. Anon: Joint FAO/WHO Expert on food additives: evaluation of certain veterinary drug residues in food. World Health Organisation, Technical Report, Geneva, Series 1988.
  • 5. Bozhkova G., Angelov L., Danov M.: Cefacetril in treatment of clinical bovine mastitis. Vet Med Nauki Sofia 1983, 20, 68-75.
  • 6. Cagnardi P., Villa R., Gallo M., Locatelli C., Carli S., Moroni P., Zonca A.: Cefoperazone sodium preparation behavior after intramammary administration in healthy and infected cows. J Dairy Sci 2010, 93, 4105-4110.
  • 7. Daeseleire E., De Ruyck H., Van Rentergherm R.: Confirmatory assay for the simultaneous detection of penicillins and cephalosporins in milk using liquid chromatography/tandem mass spectromery. Rapid Commun Mass Spectrom 2000, 14, 1404-1409.
  • 8. Friton G.M., Sobiraj A., Richter A.: Effects of various antibiotic treatments of lactating cows with subclinical mastitis. Tierarztl Prax Ausg G Grosstiere Nutztiere 1998, 26, 254-260.
  • 9. Ghidini S., Zanardi E., Varisco G., Chizzolini R.: Prevalence of molecules of β-lactam antibiotics in bovine milk in Lombardia and Emilia Romagna (Italy). Ann Fac Medic Vet Parma 2002, 22, 245-252.
  • 10. Marshall W.F., Blair J.E.: The cephalosporins. Mayo Clinic Proc 1999, 74, 187-195.
  • 11. Piskorska-Pliszczyńska J.: The validation of investigative methods - the requirement, recommendation and practice. Medycyna Wet 2002, 58, 827-831.
  • 12. Smith G.W., Gehring R., Riviere J.L., Baynes R.E.: Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows. J Am Vet Med Assoc 2004, 224, 1827-1830.
  • 13. Sorensen L.K., Snor L.K.: Determination of cephalosporins in raw bovine milk by high-performance liquid chromatography. J Chromatogr A 2000, 882, 145-151.
  • 14. Stockler R.M., Morin D.E., Lantz R.K., Constable P.D.: Effect of milking frequency and dosing interval on the pharmacokinetics of cephapirin after intramammary infusion in lactating dairy cows. J Dairy Sci 2009, 92, 4262-4275.
  • 15. Straub R.F., Voyksner R.D.: Determination of penicillin G, ampicillin, cloxacillin and cephapirin by high-performance liquid chromatography-electrospray mass spectrometry. J Chromatogr 1993, 647, 167-181.
  • 16. Takeba K., Fujinuma K., Miyazaki T., Nakazawa H.: Simultaneous determination of β-lactam antibiotics in milk by ion-pair liquid chromatography. J Chromatogr 1998, 812, 205-211.
  • 17. Terada H., Sakabe Y.: Studies on residual antibacterials in foods. IV. Simultaneous determination of penicillin G, penicillin V and ampicillin in milk by high performance liquid chromatography. J Chromatogr 1985, 348, 379-387.
  • 18. Ziv G., Nouws J.F.M.: Clinical pharmacology of cephacetrile in ruminants. Zbl Vet Med В 1977, 24, 798-811.
  • 19. Ziv G.: Practical pharmacokinetic aspect of mastitis therapy-3: Intramammary treatment. Vet Med Small Anim Clin 1980, 75, 657-670.

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Typ dokumentu

Bibliografia

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