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2009 | 69 | 3 |
Tytuł artykułu

Gaba transporter GATminus1-possitive (GATminus1plus) puncta may play an active role in modulating GABA actions in the "trained barrel cortex

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We have shown previously that classical conditioning training involving stimulation of a row of facial vibrissae (conditioning stimulus, CS) and electrical shock (unconditioned stimulus, UCS) to the tail is associated with increase in the numerical density of GAD67+ boutons located on the cognate barrel hollows. The present study was designed to determine whether the expression of GABA transporter GAT-1 changes after associative learning using the mice classical conditioning training as a model. We found that numerical density of GABA transporter GAT-1+ puncta was increased by about 50% in the neuropil of the ”trained barrel” hollow compared with controls: pseudoconditioned, whisker stimulation without UCS, and naive group of mice. The electron microscopic observations confi rm that immunoreactivity for GAT-1+ puncta was localized: in single synaptic terminals present on symmetric specialization synapses, on double-synapse spines on symmetric synapse, and on astrocytic processes. The projection of several confocal plans (3D spatial organization) identifi ed GAT-1+ coupled astrocytes. The present evidence supports the hypothesis that GABA transporter GAT-1 localized on GABAergic terminals and the astrocyte networks in the hollow of the “trained barrel” may be involved in learning-dependent changes in layer IV of the barrel cortex. Supported by MNiSW grant 188 to ES.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.305
Twórcy
autor
  • Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Department of Cytology and Histology, institute of Zoology, Jagiellonian University, Krakow, Poland
autor
  • Department of Cytology and Histology, institute of Zoology, Jagiellonian University, Krakow, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-7ed96210-69ae-48f9-8930-c10db98c5304
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