Indirect inactivation of tyrosinase in its action on tyrosine

• Autorzy: Munoz-Munoz J. L. , Garcia-Molina F. , Acosta-Motos J. R. , Arribas E. , Garcia-Ruiz P. A. , Tudela J. , Garcia-Canovas F. , Rodriguez-Lopez J. N.
• Języki publikacji: EN

Abstrakty

EN

Under aerobic conditions, tyrosinase is inactivated by dopa as a result of suicide inactivation, and, under anaerobic conditions, as a result of irreversible inactivation. However, tyrosine protects the enzyme from being inactivated by dopa under anaerobic conditions. This paper describes how under aerobic conditions the enzyme acting on tyrosine is not directly inactivated but undergoes a process of indirect suicide inactivation provoked by reaction with the o-diphenol originated from the evolution of o-dopaquinone and accumulated in the reaction medium.

Słowa kluczowe

EN

tyrosinase; tyrosine; o-diphenol; monophenol; inactivation; suicide; polyphenol oxidase

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2011
• Tom: 58
• Numer: 4
• Opis fizyczny: p.477-488,fig.,ref.

Twórcy

autor

Munoz-Munoz J. L.

• Grupo de Investigación Enzimología, Departamento de Bioquimica y Biologia Molecular-A, Facultad de Biologia, Universidad de Murcia, Espinardo, Murcia, Spain

autor

Garcia-Molina F.

autor

Acosta-Motos J. R.

autor

Arribas E.

autor

Garcia-Ruiz P. A.

autor

Tudela J.

autor

Garcia-Canovas F.

autor

Rodriguez-Lopez J. N.

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