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2009 | 69 | 3 |
Tytuł artykułu

Long-term potentiation in hippocampal basal dendrites: role of diffrent modulatory systems

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Long-term potentiation (LTP) and long-term depression (LTD) are considered to be cellular models suitable for studying the synaptic changes that likely occur during learning and memory. LTP has distinct phases, a transient protein synthesis-independent stage (early-LTP) followed under distinct circumstances by a late, longlasting and protein synthesis-dependent stage (late-LTP). In hippocampal CA1 neurons, LTP in either the apical or basal dendrites differ in their molecular requirement during induction as well as the setting of the tag, for example CaM kinase II mediates the setting of the tag in stratum radiatum but in basal dendrites (stratum oriens) the setting of the tag is mediated by either protein kinase A or protein kinase M zeta (Sajikumar et al. 2007). It has been reported that the late-LTP in the CA1 stratum radiatum requires the synergistic activation of different neurotransmitters during its induction (Frey 1997, Frey and Morris 1998). From this background we now investigated whether the LTP in stratum oriens requires similar or other synergistic interactions of different modulatory systems when compared with the stratum radiatum. Our preliminary studies using different selective antagonists of distinct modulatory transmitters systems revealed that late-LTP in basal dendrites is different with respect to its requirements for its induction when compared with late-LTP in apical CA1-dendrites.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.297-298
Twórcy
  • Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany
autor
  • Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany
autor
  • Department of Neurophysiology, Leibniz Institute for Neurobiology, Magdeburg, Germany
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-7992e032-bbac-492a-9b0e-a6fa74525004
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