Evaluation of in vitro effects of selected physical and chemical agents on detected in Poland Acanthamoeba strains - factors of increasing threats for public health

• Autorzy: Baltaza W. , Padzik M. , Szaflik J.P. , Perkowski K. , Dybicz M. , Chomicz L.
• Języki publikacji: EN

Abstrakty

EN

Acanthamoeba keratitis, the vision-threatening corneal disease reported with increasing frequency in Poland is difficult to treat due to extremely high resistance of the amoeba cysts to chemicals. The agents of possible anti-amoebic activity are still tested. Pathogenic Acanthamoeba samples/isolates acquired from severe cases of keratitis examined by molecular techniques to determine genotypes, compared to one another as well as to the environmental Acanthamoeba castellanii Neff strain were included in the studies. These strains were in vitro examined in terms of their sensitivity/resistance to selected chemicals and tolerance to temperature changes. Samples of the strains cultivated in vitro under bacteria-free conditions were monitored during different growth phases. Higher amoebic population dynamics was observed in both pathogenic Acanthamoeba strains during transfer to 37°C. Agents tested influenced population dynamics in different degree; they showed amoebostatic or amoebicidal effects, however a tendency toward induction of encystment also appeared. Because activation of the dormant cysts can lead to repeated development of amoebae, very important is cysticidal efficacy of chemicals. Further in vitro investigations on various Acanthamoeba strains with different chemicals are still necessary.

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2019
• Tom: 65
• Numer: 1
• Opis fizyczny: p.19-25,ref.

Twórcy

autor

Baltaza W.

• Department of Medical Biology, Medical University of Warsaw, Nowogrodzka 73, 02-018 Warsaw, Poland

autor

Padzik M.

• Department of Medical Biology, Medical University of Warsaw, Nowogrodzka 73, 02-018 Warsaw, Poland

autor

Szaflik J.P.

• Department of Ophthalmology, SPKSO Ophthalmic Hospital, Medical University of Warsaw, Sierakowskiego 13, 03-709 Warsaw, Poland

autor

Perkowski K.

• Department of Orthodontics, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland

autor

Dybicz M.

• Department of General Biology and Parasitology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland

autor

Chomicz L.

• Department of Medical Biology, Medical University of Warsaw, Nowogrodzka 73, 02-018 Warsaw, Poland

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Identyfikatory

DOI

10.17420/ap6501.179