Immunoexpression of constitutive and inducible cyclooxygenase isoforms in distinguishing and accessory structures of synovial joints in rat foetuses

• Autorzy: Burdan F. , Szumilo J. , Dworzanski W. , Szumilo M. , Podlodowska J. , Dyndor K. , Madej B. , Dworzanski J. , Klepacz R.
• Języki publikacji: EN

Abstrakty

EN

Joint formation is a developmental process regulated by various factors including bone morphogenetic proteins, transforming and growth factors, etc. Recently, a high expression of cyclooxygenase (COX) isoforms in the foetal cartilaginous elements was also revealed. On the other hand, various joint and skeletal abnormalities were seen in laboratory animal and human offspring, exposed in utero to several COX inhibitors. Immunoexpression of constitutive (COX-1) and inducible (COX-2) cyclooxygenase isoforms was evaluated in various articular structures of untreated and unfamiliar 21-day-old male rat foetuses. Both COX isoforms were detected in the articular cartilage and joint capsule, as well as in the intra-articular disc of the temporomandibular joint and meniscus of the knee joint. COX-1 immunostaining was revealed in the anterior and posterior cruciate ligament of the knee joint and the labrum of the hip and shoulder, whereas COX-2 immunoreactivity in those structures was not found. It could be concluded that both constitutive and inducible COX isoforms are physiologically expressed in various structures of synovial joints in rat foetuses at the end of prenatal development. (Folia Morphol 2009; 68, 2: 59–64)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2009
• Tom: 68
• Numer: 2
• Opis fizyczny: p.59-64,fig.,ref.

Twórcy

autor

Burdan F.

• Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20–090 Lublin, Poland

autor

Szumilo J.

• Clinical Pathomorphology Department, Medical University of Lublin, Poland

autor

Dworzanski W.

• Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20–090 Lublin, Poland

autor

Szumilo M.

• Applied Pharmacy Department, Medical University of Lublin, Poland

autor

Podlodowska J.

• Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20–090 Lublin, Poland
• Clinical Pathomorphology Department, Medical University of Lublin, Poland

autor

Dyndor K.

• Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20–090 Lublin, Poland

autor

Madej B.

• Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20–090 Lublin, Poland

autor

Dworzanski J.

• Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20–090 Lublin, Poland

autor

Klepacz R.

• Applied Pharmacy Department, Medical University of Lublin, Poland

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