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2017 | 77 | Suppl.1 |
Tytuł artykułu

TRPC3 and TRPV1 channels are engaged in memory consolidation in passive avoidance task in one-day old chicks

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Języki publikacji
EN
Abstrakty
EN
INTRODUCTION: The stimulation of both ionotropic and metabotropic glutamate receptors and influx of calcium ions (Ca2+) into neurons is a crucial step in intracellular cascade of memory formation. Recently the existence of additional mechanism involved in intracellular Ca2+ increase, triggered by internal signals like increase of Ca2+ within the cell and activation of G protein coupled receptors, was demonstrated. This mechanism involves transient receptor potential (TRP) channels. AIM(S): The aim of our study was to investigate the participation of TRP channels in intracellular mechanisms engaged in memory consolidation METHOD(S): The model of passive avoidance task in one day old chicks was used. Chicks were injected with non-specific TRP channels antagonist SKF96365 or with specific antibodies against chosen TRP channels: TRPC3, TRPC5, TRPV1 and TRPV3. The injections were made into brain region connected with memory formation – intermediate medial mesopallium – immediately after training (time choice based on previous experiments) and animals were tested 2 h and 24 h after training RESULTS: The injection of SKF96365 and anti-TRPC3 antibody immediately after training resulted in strong task amnesia when tested 2 h and 24 h later. Injection of anti-TRPV1 and anti-TRPV3 antibody resulted in less manifested amnesia, whereas application of anti-TRPC5 antibody did not produce significant amnesia. CONCLUSIONS: Our results show that inhibition of TRPC3, TRPV1 and TRPV3 channels significantly disturbed memory of the task indicating on an involvement of these channels in memory formation. FINANCIAL SUPPORT: G1136-2014/15/B/NZ4/04487.
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77
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Opis fizyczny
p.117
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autor
  • Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
  • Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
autor
  • Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
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