Wpływ przebiegu porodu na stężenie IGF-I w surowicy zimnokrwiostych klaczy i ich nowo narodzonych źrebiąt

• Autorzy: Kowalik S. , Kedzierski W. , Kusy R.

Warianty tytułu

EN

Effect of the type of parturition on IGF-I concentration in blood serum of cold-blooded mares and their foals

• Języki publikacji: PL

Abstrakty

EN

Insulin-like growth factor I (IGF-I) is a polipeptyde hormone produced mainly by the liver in response to the endocrine growth hormone stimulus, but it is also secreted by multiple tissues for autocrine or paracrine purposes. IGF-I represents one of the most important growth regulators, playing a central role in fetal and neonatal growth. However, the role of IGF-I in the reproductive physiology of horses is still little known. Therefore, the aims of this work were 1) to evaluate the IGF-I serum concentration in mares during the first 4 days after parturition and in their newborn foals during the first 4 days of life, and 2) to determine whether the IGF-I concentration may be influenced by the type of parturition. Two groups of subjects were examined: 7 healthy mares and their foals born by spontaneous parturition (group F), and 10 healthy mares and their foals born by non-spontaneous parturition, requiring medical assistance (group P). From each animal, the first blood samples were collected within 30 min of birth, and then, daily, during 4 days after parturition. The samples were collected once a day at 8.00 a.m. IGF-I was analyzed by the radioimmunoassay method with the IGF-RIA-CT kit (BioSource, Belgium). The results revealed that the mares from the group P had a statistically significantly higher concentration of IGF-I compared with the mares from the group F (90.9 ± 7.02 vs. 40.9 ± 5.94 ng/ml, respectively, p ≤ 0.01). Similarly, the statistically higher values of this factor were found in the foals from the group P than in those from the group F (130 ± 8.59 vs. 83.1 ± 6.56 ng/ml, respectively, p ≤ 0.01). Furthermore, a positive correlation was found between the concentration of IGF-I in the blood serum of mares and their foals on the first day of the study (r = 0.50, p ≤ 0.05). In summary, disturbances in the course of parturition did not have a negative impact on the IGF-I level in either mares or their newborn foals.

Słowa kluczowe

PL

konie; konie zimnokrwiste; klacze [zool.]; przebieg porodu; zrebieta; noworodki; surowica krwi; insulinopodobny czynnik wzrostu-I; stezenie insulinopodobnego czynnika wzrostu-I

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2015
• Tom: 71
• Numer: 07
• Opis fizyczny: s.448-452,rys.,tab.,bibliogr.

Twórcy

autor

Kowalik S.

• Katedra Fizjologii Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul.Akademicka 12, 20-033 Lublin

autor

Kedzierski W.

• Katedra Biochemii, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul.Akademicka 12, 20-033 Lublin

autor

Kusy R.

• Katedra i Klinika Rozrodu Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul.Głęboka 30, 20-612 Lublin

Bibliografia

• 1. Ashworth M. D., Ross J. W., Stein D. R., Allen D. T., Spicer L. J., Geisert R. D.: Endocrine disruption of uterine insulin-like growth factor expression in the pregnant gilt. Reproduction 2005, 130, 545-551.
• 2. Badinga L., Song S., Simmen R. C. M., Clarke J. B., Clemmons D. R., Simmen F. A.: Complex mediation of uterine endometrial epithelial cell growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2. J. Mol. Endocrinol. 1999, 23, 277-285.
• 3. Bercvarova I., Buechner-Maxwell V.: Feeding the foal for immediate and long-term health. Equine Vet. J. 2012, 44 (suppl. 41), 149-156.
• 4. Berg E. L., McNamara D. L., Keisel D. H.: Endocrine profiles of periparturient mares and their foals. J. Anim. Sci. 2007, 85, 1660-1668.
• 5. Bobowiec R., Kędzierski W., Martelli F., Kosior-Korzecka U.: Współzależność między losem dojrzałych pęcherzyków jajnikowych a profilem hormonalnym i poziomem IGF-I u klaczy. Med. Weter. 2004, 60, 1098-1102.
• 6. Cavinder C. A., Vogelsang M. M., Gibbs P. G., Forrest D. W., Schmitz D. G.: Endocrine profile comparisons of fat versus moderately conditioned mares following parturition. J. Equine Vet. Sci. 2007, 27, 72-79.
• 7. Cymbaluk N. F., Laarveld B.: The ontogeny of serum insulin-like growth factor-I concentration in foals: effects of dam parity, diet and age at weaning. Dom. Anim. Endocrinol. 1996, 13, 197-209.
• 8. Davies S. C., Wass J. A. H., Ross R. J. M., Cotterill A. M., Buchanan C. R., Coulson V. J., Holly J. M. P.: The induction od specific protease for insulin-like growth factor binding protein-3 in the circulation during severe illness. J. Endocrinol. 1991, 130, 469-473.
• 9. Davies Morel M. C. G.: Equine reproductive physiology, breeding and stud management. 3rd ed, CAB International 2008, s. 186.
• 10. Deichsel K., Aurich J., Parvizi N., Bruckmaier R. M., Aurich C.: LH and IGF-1 release during oestrus and early luteal phase in lactating and non-lactating horse mares. Anim. Rep. Sci. 2006, 91, 97-106.
• 11. Derar D. R., Taya K., Watanabe G., Miyake Y. I.: Characterization of immunoreactive IGF-I pattern during the peri-ovulatory period of the oestrous cycle of thoroughbred mares and its relation to other hormones. Reprod. Dom. Anim. 2012, 47, 151-156.
• 12. Fowden A. L.: The insulin-like growth factors and feto-placental growth. Placenta 2003, 24, 803-812.
• 13. Fowden A. L., Forhead A. J., Ousey J. C.: Endocrine adaptations in the foal over the perinatal period. Equine Vet. J. 2012, 41 (suppl. 41), 130-139.
• 14. Guidi A., Castigliego L., Iannone G., Armani A., Gianfaldoni D.: An immunoenzymatic method to measure IGF-I in milk. Vet. Res. Commun. 2007, 31 (Suppl. 1), 373-376.
• 15. Hanssen-Pupp I., Löfqvist C., Polberger S., Niklasson A., Fellman V., Hellström A., Ley D.: Influence of Insulin-Like Growth Factor I and Nutrition During Phases of Postnatal Growth in Very Preterm Infants. Pediatric Res. 2011, 5, 448-453.
• 16. Heidler B., Parvizi N., Sauerwein H., Bruckmaier R. M., Heintges U., Aurich J. E., Aurich C.: Effects of lactation on metabolic and reproductive hormones in Lipizzaner mares. Dom. Anim. Endocrinol. 2003, 25, 47-59.
• 17. Henson F. M. D., Davenport C., Butler L., Moran I., Shingelton W. D., Jeffcott L. B., Schofield P. N.: Effects on insulin and insulin-like growth factors I and II on the growth of equine fetal and neonatal chondrocytes. Equine Vet. J. 1997, 29, 441-447.
• 18. Hess-Dudan F., Vacher P. Y., Bruckmaier R. M., Weishaupt M. A., Burger D., Blum J. W.: Immunoreactive insulin-like factor I and insulin in blood plasma and milk of mares and in blood plasma of foals. Equine Vet. J. 1994, 26, 134-139.
• 19. Hiden U., Glitzner E., Hartmann M., Desoye G.: Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J. Anat. 2009, 215, 60-68.
• 20. Holt R. I.: Fetal programming of the growth hormone-insulin-like growth factor axis. Trends Endocrinol. Metab. 2002, 13, 392-397.
• 21. Krakowski L., Wrona Z., Kostro K., Zdzińska B.: Stężenie insulinopodobnych czynników wzrostu IGF-I i IGF-II w surowicy źrebnych klaczy w okresie okołoimplantacyjnym. Med. Weter. 2008, 64, 237-239.
• 22. Lelu C., Haentjens F.: Morphological, haemato-biochemical and endocrine changes in young Standardbreds with ‘maladaptation’ to early training. Equine Vet. J. 2010, 42 (Suppl. 38), 171-178.
• 23. Łuszczyński J., Pieszka M.: Effect of season on plasma concentration of insulin-like growth factor-I and 1.25 dihydroxycholecalciferol in horses. Acta Sci. Pol., Zootechnica 2011, 10, 45-54.
• 24. Malinowski K., Christensen R. A., Hafs H. D., Scanes C. G.: Age and breed differences in thyroid hormones, insulin-like growth factor (IGF)-I and IGF binding proteins in female horses. J. Anim. Sci. 1996, 74, 1936-1942.
• 25. Moura E. G. de, Passos M. C. F.: Neonatal programming of body weight regulation and energetic metabolism. Biosci. Rep. 2005, 25, 251-269.
• 26. Munoz A., Trigo P., Riber C., Malonda V., Castejon F.: A study of serum insulin-like growth factor type 1 (IGF-1) concentration in resting untrained Andalusian horses: influence of age and gender. Veterinarni Medicina 2011, 56, 231-242.
• 27. Noble G. K., Houghton E., Roberts C. J., Faustino-Kemp J., de Kock S. S., Swanepoel B. C., Sillence M. N.: Effect of exercise, training, circadian rhythm, age, and sex on insulin-like growth factor-1 in the horse. J. Anim. Sci. 2007, 85, 163-171.
• 28. Panzani S., Castagnetti C., Prandi A., Faustini M., Zamboni A., Veronesi M. C.: Insulin-like growth factor I: Could it be a marker of prematurity in the foal? Theriogenology 2013, 79, 495-501.
• 29. Panzani S., Comin A., Galeati G., Romano G., Villani M., Faustini M., Veronesi M. C.: How type of parturition and health status influence hormonal and metabolic profiles in newborn foals. Theriogenology 2012, 77, 1167-1177.
• 30. Panzani S., Villani M., McGladdery A., Magri A., Kindhal H., Galeati G., Martino P. A., Veronesi M. C.: Concentrations of 15-ketodihydro-PGF2alpha, cortisol, and progesterone in the plasma of healthy and pathologic newborn foals. Theriogenology 2009, 72, 1032-1040.
• 31. Paye J. M. D., Forsten-Williams K.: Regulation of insulin-like growth factor-I (IGF-I) delivery by IGF binding proteins and receptors. Annals of Biomedical Engineering 2006, 34, 618-632.
• 32. Puche J. E., Castilla-Cortázar I.: human conditions of insulin-like growth factor-I (IGF-I) deficiency. J. Transl. Med. 2012, 10, 244-253.
• 33. Robinson R. S., Mann G. E., Gadd T. S., Lamming G. E., Wathes D. C.: The expression of the IGF system in the bovine uterus throughout the oestrus cycle and early pregnancy. J. Endocrinol. 2000, 165, 231-243.
• 34. Ropp J. K., Raub R. H., Minton J. E.: The effect of dietary energy source on serum concentration of insulin-like growth factor-I, growth hormone, insulin, glucose, and fat metabolites in weanling horses. J. Anim. Sci. 2003, 81, 1581-1589.
• 35. Ross R. J., Rodriguez-Arnao J., Bentham J., Coakley J. H.: The role of insulin, growth hormone and IGF-I as metabolic agents in the critically ill. Intensive Care Med. 1993, 19, 54-57.
• 36. Simmen R. C. M., Green M. J., Simmen F. A.: IGF system in periimplantation uterus and embryonic development. Molecular and Cellular Aspects of Periiplantation Processes, Serono Symposia 1995, 185-204.
• 37. Staniar W. B., Kronfeld D. S., Akers R. M., Harris P. A.: Insulin-like growth factor I in growing thoroughbreds. J. Anim. Physiol. Anim. Nutr. 2007, 91, 390-399.
• 38. Toribio R. E.: Endocrine dysregulation in critically ill foals and horses. Vet. Clin. North. Am. Equine Pract. 2011, 27, 35-47.
• 39. Walters K. W., Roser J. F., Anderson G. B.: Maternal-conceptus signaling during early pregnancy in mares: oestrogen and insulin-like growth factor I. Reproduction 2001, 121, 331-338.