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2018 | 74 | 12 |

Tytuł artykułu

Effectiveness of capsaicin containing dried habanero pepper extract in the treatment of primary hepatic cancer in geriatric dogs

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The study was aimed at the preliminary clinical assessment of the anti-cancer efficacy of a dietary supplement based on the extract of habanero peppers containing capsaicin in dogs with primary hepatic cancer. 24 dogs with primary hepatic cancer, divided into two groups, were followed up during the study. Group I included 16 dogs receiving a dietary supplement based on capsaicin-containing habanero peppers, while group II consisted of 8 dogs that did not receive any veterinary treatment. The dogs were subjected to clinical examination, ultrasound imaging as well as biochemical and haematological analyses. Patient survival was determined in both groups. An autopsy was performed in all animals that died or were euthanised, and tumour samples were collected for histopathological examination, on the basis of which the type of neoplasm was finally determined. Survival of dogs in group I ranged from 54 to 285 days (178.6 days on average). Survival of dogs in group II was 32-128 days (76.5 days on average). In none of the dogs classified to group I that had single tumours did the size of the lesion increase during supplement administration, and in the case of two dogs that were receiving the preparation for a long time (188 and 285 days), their liver tumours actually shrank. In all dogs from group II that had single tumours, the size of the lesions increased in the course of the observation. The preliminary clinical observations by the authors indicate that the capsaicin-containing habanero pepper extract exhibits favourable effects on liver tumours in dogs and is well tolerated by the animals, thus the obtained results are a good sign for future studies on alternative medications used in dog oncology.

Wydawca

-

Rocznik

Tom

74

Numer

12

Opis fizyczny

p.765-771,fig.,ref.

Twórcy

autor
  • Laboratory of Radiology and Ultrasonography, Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland
autor
  • ARKONA L.F.S, Nasutow 21, 21-025 Nasutow, Poland
autor
  • Sub-Department of Pathomorphology and Forensic Veterinary Medicine, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland
autor
  • Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland
autor
  • Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland
  • Laboratory of Radiology and Ultrasonography, Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland
  • Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland
autor
  • Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Gleboka 30, 20-612 Lublin, Poland

Bibliografia

  • Adaszek Ł., Gadomska D., Staniec M., Gołyński M., Łyp P., Ziętek J., Różańska D., Orzelski M., Śmiech A., Winiarczyk S.: Clinical assessment of the anti-cancer activity of the capsaicin-containing habanero pepper extract in dogs – preliminary study. Med. Weter. 2017, 73, 404-411.
  • Anandakumar P., Kamaraj S., Jagan S., Ramakrishnan G., Asokkumar S., Naveenkumar C., Raghunandhakumar S., Devaki T.: Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm. Res. 2012, 61, 1169-1175.
  • Brown K. C., Witte T. R., Hardman W. E., Luo H., Chen Y. C., Carpenter A. B., Lau J. K., Dasgupta P.: Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS ONE 2010, 5, 10243.
  • Chakraborty S., Mazumdar M., Mukherjee S., Bhattacharjee P., Adhikary A., Manna A., Chakraborty S., Khan P., Sen A., Das T.: Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells. FEBS Lett. 2014, 588, 549-559.
  • Chen X., Tan M., Xie Z., Feng B., Zhao Z., Yang K., Hu C., Liao N., Wang T., Chen D., Xie F., Tang C.: Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells. Free Radic. Res. 2016, 50, 744-755.
  • Clark R., Lee. J., Lee S. H.: Synergistic anticancer activity of capsaicin and 3,3′-Diindolylmethane in human colorectal cancer. J. Agric. Food Chem. 2015, 63, 4297-4304.
  • Cromer B. A., McIntyre P.: Painful toxins acting at TRPV1. Toxicon 2008, 51, 163-173.
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  • Dobson J., Lascelles D.: BSAVA Manual of Canine and Feline Oncology. BSAVA, Quedgeley, Gloucester 2011.
  • Gilardini Montani M. S., D’Eliseo D., Cirone M., Di Renzo L., Faggioni A., Santoni A., Velotti F.: Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91. Nutrition 2015, 31, 578-581.
  • Golyński M., Balicki I., Lutnicki K., Smiech A., Adamek L., Szczepanik M., Wilkolek P., Brodzki A., Adaszek L.: Systemic and local effects of intragastric administration of the habanero fruit (Capsicum chinense Jacquin c.v.) in rats. J. Physiol. Pharmacol. 2015, 66, 259-265.
  • Head K. W., Cullen J. M., Dubielzig R. R., Else R. W., Misdorp W., Patnaik A. K., Tateyama S., van der Gaag I.: Histological classification of tumors of the alimentary system of domestic animals. Armed Forces Institute of Pathology, Washington, D.C. 2003.
  • Huang S. P., Chen J. C., Wu C. C., Chen C. T., Tang N. Y., Ho Y. T., Lo C., Lin J. P., Chung J. G., Lin J. G.: Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res. 2009, 29, 165-174.
  • Kim J. D., Kim J. M., Pyo J. O., Kim S. Y., Kim B. S., Yu R., Han I. S.: Capsaicin can alter the expression of tumor forming-related genes which might be followed by induction of apoptosis of a Korean stomach cancer cell line, SNU-1. Cancer Lett. 1997, 120, 235-241.
  • Lee G. R., Jang S. H., Kim C. J., Kim A. R., Yoon D. J., Park N. H., Han I. S.: Capsaicin suppresses the migration of cholangiocarcinoma cells by downregulating matrix metalloproteinase-9 expression via the AMPK-NF-kappaB leomorphi pathway. Clin. Exp. Metastasis 2014, 31, 897-907.
  • Mann C. D., Neal C. P., Garcea G., Manson M. M., Dennison A. R., Berry D. P.: Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis. Eur. J. Cancer Prev. 2009, 18, 13-25.
  • Min J. K., Han K. Y., Kim E. C.: Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res. 2004, 64, 644-651.
  • Mori A., Lehmann S., O’Kelly J., Kumagai T., Desmond J. C., Pervan M., McBride W. H., Kizaki M., Koeffler H. P.: Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res. 2006, 15, 3222-3229.
  • O’Neil R. G., Brown R. C.: The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli. News Physiol. Sci. 2003, 18, 26-31.
  • Pramanik K. C., Fofaria N. M., Gupta P., Srivastava S. K.: CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol. Cancer Ther. 2014, 13, 687-698.
  • Skrzypski M., Sassek M., Abdelmessih S., Mergler S., Grotzinger C., Metzke D., Wojciechowicz T., Nowak K. W., Strowski M. Z.: Capsaicin induces cytotoxicity in pancreatic neuroendocrine tumor cells via mitochondrial action. Cell Signal. 2014, 26, 41-48.
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  • Venier N. A., Colquhoun A. J., Sasaki H., Kiss A., Sugar L., Adomat H., Fleshner N. E., Klotz L. H., Venkateswaran V.: Capsaicin: a novel radio-sensitizing agent for prostate cancer. Prostate 2015, 75, 113-125.
  • Venier N. A., Yamamoto T., Sugar L. M., Adomat H., Fleshner N. E., Klotz L. H., Venkateswaran V.: Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model. Prostate 2015, 75, 1300-1311.
  • Wutka A., Palagani V., Barat S., Chen X., El K. M., Gotze J., Belahmer H., Zender S., Bozko P., Malek N. P.: Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis. PloS ONE 2014, 9, 95605.
  • Yang D., Luo Z., Ma S., Wong W. T., Ma L., Zhong J., He H., Zhao Z., Cao T., Yan Z., Liu D., Arendshorst W. J., Huang Y., Tepel M., Zhu Z.: Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab. 2010, 4, 130-141.
  • Zheng J., Zhou Y., Li Y., Xu D. P., Li S., Li H. B.: Spices for prevention and Treatment of Cancers. Nutrients 2016, 8, 495.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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