5-HT1A receptors are involved in the development of theta oscillations in hippocampal formation in vitro

• Autorzy: Kazmierska P. , Urbaniak L. , Caban B. , Bocian R. , Kowalczyk T. , Wieczorek M. , Konopacki J.
• Języki publikacji: EN

Abstrakty

EN

Hippocampal formation (HPC) is a limbic structure that generates a synchronized EEG activity, termed the theta rhythm. The theta rhythm is a sinusoidal activity with a frequency band ranging from 3 to 12 Hz. Many years of research conducted with the use of the model of HPC slice preparations allowed to determine the specific role of the cholinergic and GABAergic systems in the production of this EEG pattern. In addition, the literature data indicate that serotonergic input may be involved in the desynchronization of hippocampal theta. To verify this suggestion a micro-EEG recording were performed on HPC slices obtained from 20 male Wistar rats. All experiments were monitored by a Local Ethical Commission. Field potentials and extracellular recordings were made from the CA3c hippocampal field during the bath perfusion of a 5-HT1A receptor antagonist, (S)WAY-100135 in a range of concentrations in the following µM ratio: 1:3: 10:30 and 100. Preliminary results showed that besides epileptiform discharges, oscillatory activity in theta band was observed only in the slices perfused with 10 µM (S) WAY-100135. This demonstrates that the synchronization of neuronal networks needs the appropriate and precise level of excitation which can also be achieved by the manipulation of HPC 5-HT1A receptors activity. This study was supported by the NSC grant No.2011/01/N/ NZ4/01722.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.37-38

Twórcy

autor

Kazmierska P.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Urbaniak L.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Caban B.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Bocian R.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Kowalczyk T.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Wieczorek M.

• Department of Neurobiology, University of Lodz, Lodz, Poland

autor

Konopacki J.

• Department of Neurobiology, University of Lodz, Lodz, Poland