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2012 | 56 | 3 |

Tytuł artykułu

Clinical, Biochemical and haemodynamics effects of the intrathecal ketamine for ovariohysterectomy in bitches

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The purpose of the study was to evaluate the effects of intrathecal (IT) ketamine HCl anesthesia on clinical values and some haemodynamic and biochemical parameters in bitches. An IT ketamine (10 mg/kg) was administered to 30 bitches with a spinal needle (18-22 G) in the lumbosacral space. The haemodynamic parameters were monitored and some biochemical values were assessed (blood gase, oxygen-haemoglobin, and electrolyte levels). The length and depth of anaesthesia was determined with a pinprick test, touching to the ligamenta lata uteri and incision. Anaesthesia took effect in less than 1 min in all dogs and has lasted an average of 95.9 min. In spite of the fact that the dogs recovered completely from the effects of dissociative anaesthesia, the anaesthesia in the some extremities was observed to be continued for an average of 17 min longer. The use of IT ketamine HCl raised blood pressure and did not have a depressive effect on respiratory and cardiac functions. It was concluded that ketamine HCl could be an appropriate alternative for ovariohysterectomy operations in bitches when the quality of the anaesthesia and the prevention of bradycardia and hypotension are considered.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

56

Numer

3

Opis fizyczny

p.299-303,ref.

Twórcy

autor
  • Department of Surgery, Faculty of Veterinary Medicine, University of Kafkas, 36300, Kars, Turkey
autor
autor
autor
autor
autor
autor

Bibliografia

  • 1. Acosta A.D., Gomar C., Correa-Natalini C., Bopp S., Polydoro A., Sala-Blanch X.: Analgesic effects of epidurally administered levogyral ketamine alone or in combination with morphine on intraoperative and postoperative pain in dogs undergoing ovariohysterectomy. Am J Vet Res 2005, 66, 54-61.
  • 2. Adachi H., Inagaki Y., Okazaki N., Ishibe Y.: Racemic ketamine and s(+)-ketamine concentrations in cerebrospinal fluid after epidural and intravenous administration in rabbits. Yonago Acta Med 2005, 48, 33-40.
  • 3. Atalan G., Demirkan İ., Günes V., Cihan M., Celebi F., Citil M.: Comparison of xylazine + ketamine-HCL anaesthetic agents with acepromazine + butorphanol + ketamine combinations for their clinical and cardiorespiratory effects in dogs. J Turkish Vet Surg 2002, 8, 35-40.
  • 4. Borgbjerg F.M., Svensson B.A., Frigast C., Gordh T.: Histopathology after repeated intrathecal injections of preservative-free ketamine in the rabbit: a light and electron microscopic examination. Anesth Analg 1994, 79, 105-111.
  • 5. Blue J.T., Short C.E.: Preanesthetic evaluation and clinical pathology. In: Principles and Practice of Veterinary Anesthesia, edited by Short C.E. Williams & Wilkins, Baltimore 1987, pp. 3-7.
  • 6. El Shobary H.M., Sonbul Z.M., Schrickcr T.P.: Epidural ketamine for postoperative analgesia in the elderly. M E J Anesth 2008, 19, 1369-1378.
  • 7. Fridericia L.S.: Die systolendauer im electrocardiogramm bei normalen menchen und bei herzkranken. Acta Med Scand 1920, 53, 469-486.
  • 8. Govindan K., Krishnani R., Kaufman M.P., Michael R., Fogler R.J., Gintautus J.: Intrathecal ketamine in surgeries for lower abdomen and lower extremites. Proc Pharmacol Soc 2001, 44, 197-199.
  • 9. Hodgson P.S., Neal J.M., Pollock J.E., Liu S.S.: The neurotoxicity of drugs given intrathecally (spinal). Anesth Analg 1999, 88, 797-809.
  • 10. Iida H., Dohi S., Tanahashi T., Watanabe Y., Takenaka M.: Spinal conduction block by intrathecal ketamine in dogs. Anesth Analg 1997, 85, 106-10.
  • 11. Kacar C., Ozaydin I., Oral H., Kilic E., Gurbulak K., Aksoy O.: Intrathecal slow infusion of isobaric bupivacaine HCl in low-dose for ovariohysterectomy in dogs. Bull Vet Inst Pulawy 2007, 51, 89-92.
  • 12. Kamiloglu A., Atalan G., Ozturk S., Kilic E.: Epidural injection of ketamine hydrocloride for perineal analgesia in cattle. Ir Vet J 2003, 56, 514-516.
  • 13. Kathirvel S., Sadhasivam S., Saxena A., Kanan T.R., Ganjoo P.: Effects of intrathecal ketamine added to bupivacaine for spinal anaesthesia. Anaesthesia 2000, 55, 899-910.
  • 14. Koc Y., Kul M., Alkan F., Ogurtan Z.: The effects of midazolam-ketamine and xylazine-ketaminc on arterial blood pressure and blood gases in dogs. Eurasian J Vet Sci 2002, 18, 57-62.
  • 15. Kohrs R., Durieux M.E.: Ketamine: teaching an old drug new tricks. Anesth Analg 1998, 87, 1186-1193.
  • 16. Lee I., Yoshiuchi T., Yamagishi N., Oboshi K., Ayukawa Y., Sasaki N., Yamada H.: Analgesic effect of caudal epidural ketamine in cattle. J Vet Sci 2003, 4, 261-264.
  • 17. Lee I.O., Lee I.H., Lee K.C.: Prc-versus post-formalin effects of intrathecal ketamine on spinal fos-like immunoreactivity in rats. Indian J Med Res 2004, 120, 527-533.
  • 18. Lizarraga I., Chambers J.P., Johnson C.B.: Prevention of N-methyl-d-aspartate-induced mechanical nociception by intrathecal administration of ketoprofen and ketamine in sheep. Anesth Analg 2008, 107, 2061-2067.
  • 19. Malinovsky J.M., Lepage J.Y., Cozian A., Mussini J.M., Pinaudt M., Souron R.: Is ketamine or its preservative responsible for neurotoxicity in the rabbit? Anesthesiology 1993, 78, 109-115.
  • 20. Miyamoto H., Saito Y., Kirihara Y., Hara K., Sakura S., Kosaka Y.: Spinal coadministration of ketamine reduces the development of tolerance to visceral as well as somatic antinociception during spinal morphine infusion. Anesth Analg 2000, 90, 136-141.
  • 21. Ozaydin I., Kilic E.: Lumbosacral intrathecal anaesthesia with isobaric bupivacaine in cattle. Indian Vet J 2003, 80, 540-542.
  • 22. Reich D.L., Silvay G.: Ketamine: an update on the first twenty-five years of clinical experience. Can J Anaesth 1989, 36, 186-197.
  • 23. Samantaray A., Rao M.H.: Evaluation of midazolam as an additive to intrathecal ketamine. J Anaesth Clin Pharmacol, 2006, 22, 363-369.
  • 24. Schuszler L., Igna C., Sala A., Brudiu I., Sabau M., Dascalu R.: Intraoperative analgesic effect of butarphanol for ovariohysterectomy in bitches: a dose titration study. Lucrari Ştiintifice Med Vet 2009, 2, 160- 163.
  • 25. Slingsby L.S., Waterman-Pearson A.E.: The postoperative analgesic effects of ketamine after canine ovariohysterectomy-a comparison between pre-or postoperative administration. Res Vet Sci 2000, 69, 147- 152.
  • 26. Vranken J.H., Troost D., Haan P., Pennings F.A., Van der Vegt M.H., Dijkgraaf M.G.W., Hollmann M.W.: Severe toxic damage to the rabbit spinal cord after intrathecal administration of preservative-free s(+)- ketamine. Anesthesiology 2006, 105, 813-818.
  • 27. Yayla S., Kilic E.: The comparison of clinical, histopathological and some hemodynamic effects of spinal anesthesia applied in dogs through bupivacaine HCl and ropivacaine HCl in two different concentrations. Kafkas Univ Vet Fak Derg 2010, 16, 835-840.
  • 28. Torske K.E., Dyson D.H.: Epidural analgesia and anesthesia. Vet Clin North Am Small Anim Pract 2000, 30, 859-874.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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