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2009 | 69 | 3 |
Tytuł artykułu

Cytokine-mediated cross-talk between glia and neurons: neuropathological implications for epilepsy

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Recent fi ndings in experimental models and in the clinical setting highlight the possibility that infl ammatory processes in the brain contribute to the etiopathogenesis of seizures and to the establishment of a chronic epileptic focus. Prototypical infl ammatory cytokines such as IL-1β and TNF-α are overexpressed in epileptogenic brain areas, prominently by glia and to a lesser extent by neurons and endothelial cells of the blood brain barrier. Cytokine receptors are also upregulated, and the related intracellular signalling is activated, highlighting both autocrine and paracrine actions of cytokines in diseased brain. Cytokines can profoundly affect neuronal network excitability, and the recent demonstration of molecular and functional interactions between cytokines and classical neurotransmitters, such as glutamate and GABA, provides one mechanism by which cytokines affect neuronal activity. These interactions may result in increased tissue excitability leading to seizures and cell loss. These fi ndings describe novel communications between glia and neurons which may contribute to pathological conditions (e.g. seizures, neurodegeneration) characterized by the activation of infl ammatory processes, thus highlighting potential new targets for therapeutic intervention.
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.274
Twórcy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
autor
  • Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-66dc4532-0ba5-41f8-9efe-8068b90dd8bd
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