Vitamin D in SARS-CoV-2 infection

• Autorzy: Decyk A. , Kobylinska M. , Antosik K. , Kurowska K.
• Języki publikacji: EN

Abstrakty

EN

Background. SARS-CoV-2 virus is one of the largest RNA viruses, included in the coronavirus group, showing tropism to airway epithelial cells. SARS-CoV-2 causes an acute respiratory infectious disease, Covid-19. According to WHO reports, mortality due to Covid-19 is higher in the elderly and in those burdened with comorbidities such as diabetes, obstructive pulmonary disease, coronary artery disease, cancer, hypertension, hepatitis B, obesity or chronic kidney disease. Objective. The aim of the study was to review the current literature on the influence and importance of vitamin D levels on the course of SARS-CoV-2 infection. Material and method. A systematic review of studies published from January 1, 2009 to June 31, 2021 has been performed. For this purpose, bibliographic databases such as PubMed and Scopus were searched. The following keywords and combinations were used: Covid-19, vitamin D, 25-hydroxy-vitamin D, vitamin D supplementation, SARS-CoV-2. Results. It has been shown that vitamin D plays an important role in the mechanisms of the innate immunity in the course of the acute respiratory infections. The overlapping factors of the severity of COVID-19 disease, vitamin D deficiency, and the prevalence of obesity, age scare, ethnicity, has led some researchers to hypothesize that vitamin D supplementation may be promising as a preventive or therapeutic measure for COVID-19. Conclusions. A very important factor that has an immunomodulatory character is vitamin D, the adequate supplementation of which can be a preventive or therapeutic measure in case of SARS-CoV-2 infection, especially in elderly people, with obesity and other chronic diseases.

PL

Wstęp. Wirus SARS-CoV-2 to jeden z największych wirusów RNA, zaliczany do grupy koronawirusów, wykazujący tropizm do komórek nabłonka dróg oddechowych. SARS-CoV-2 powoduje ostrą chorobę zakaźną układu oddechowego, Covid-19. Według doniesień WHO śmiertelność z powodu Covid-19 jest wyższa u osób starszych i obciążonych chorobami współistniejącymi, takimi jak cukrzyca, obturacyjna choroba płuc, choroba wieńcowa, nowotwory, nadciśnienie, zapalenie wątroby typu B, otyłość czy przewlekła choroba nerek. Cel. Celem pracy był przegląd aktualnej literatury dotyczącej wpływu i znaczenia poziomu witaminy D na przebieg zakażenia SARS-CoV-2 Materiał i metody. Przeprowadzono systematyczny przegląd badań opublikowanych od 1 stycznia 2009 r. do 31 czerwca 2021 r. W tym celu przeszukano bazy bibliograficzne, takie jak baza PubMed i baza Scopus firmy Elsevier. Zastosowano następujące słowa kluczowe i kombinacje: Covid-19, witamina D, 25-hydroksy-witamina D, suplementacja witaminą D, SARS-CoV-2. Wyniki. Wykazano, że witamina D odgrywa ważną rolę w mechanizmach odporności wrodzonej w przebiegu ostrych infekcji dróg oddechowych. Nakładanie się czynników ciężkiego przebiegu choroby COVID-19, niedoboru witaminy D oraz występowania otyłości, straszy wiek, pochodzenie etniczne, doprowadził niektórych badaczy do hipotezy, że suplementacja witaminy D może być obiecująca jako środek zapobiegawczy lub terapeutyczny w przypadku COVID-19. Wnioski. Bardzo ważnym czynnikiem o charakterze immunomodulującym jest witamina D, której odpowiednia suplementacja może być środkiem zapobiegawczym lub terapeutycznym w przypadku zakażenia SARS-CoV-2, zwłaszcza u osób starszych, z otyłością i innymi chorobami przewlekłymi.

Słowa kluczowe

EN

COVID-19; SARS-CoV-2 virus; COVID-19 pandemic; vitamin D3; supplementation

PL

COVID-19; koronawirus SARS-CoV-2; pandemia COVID-19; witamina D3; suplementacja

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2022
• Tom: 73
• Numer: 1
• Opis fizyczny: p.5-12,ref.

Twórcy

autor

Decyk A.

• Faculty of Medical and Health Sciences, University of Natural Sciences and Humanities in Siedlce, Poland

autor

Kobylinska M.

• Faculty of Medical and Health Sciences, University of Natural Sciences and Humanities in Siedlce, Poland

autor

Antosik K.

• Faculty of Medical and Health Sciences, University of Natural Sciences and Humanities in Siedlce, Poland

autor

Kurowska K.

• Faculty of Medical and Health Sciences, University of Natural Sciences and Humanities in Siedlce, Poland

Bibliografia

• 1. Abu el Maaty M.A., Wölfl S. Vitamin D as a novel regulator of tumor metabolism: insights on potential mechanisms and implications for anti-cancer therapy. Int J Mol Sci 2017;18:1-12.
• 2. Alfatlawi W.R., Ali Z.M, Aldabagh M.A.G. Impact of Vitamin D Elements in Insulin Sensitivity in Type 2 Diabetes Mellitus (DM2), Medico Legal Update 2021;21:1499-1504.
• 3. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity, J Infect Public Health 2020;13:1373-1380.
• 4. Azhideh A. COVID-19 neurological manifestations. Int Clin Neurosci J 2020;7(2):54-54.
• 5. Bergman P. Witamina D a występowanie i leczenie zapaleń przyzębia – przegląd piśmiennictwa [The link between vitamin D and Covid‐19: Distinguishing facts from fiction]. J Intern Med 2021;289:131–133 (in Polish).
• 6. Bernard J.J., Gallo R.L., Krutmann J. Photoimmunology: how ultraviolet radiation affects the immune system. Nat Rev Immunol 2019;19:688– 701.
• 7. Biesalski H.K. Obesity, vitamin D deficiency and old age a serious combination with respect to coronavirus disease-2019 severity and outcome. Curr Opin Clin Nutr Metab Care 2021;24:18-24.
• 8. Brzeska M.E., Mazurek-Mochol M., Dembowska E. Vitamin D and the occurrence and treatment of periodontitis–review of literature. J Stomatol. 2016;70:586-595.
• 9. Choi C.J., Seo M., Choi W.S., Kim K.S., Youn S.A., Lindsey T., Choi Y.J., Kim C.M. Relationship between serum 25-hydroxyvitamin D and lung function among Korean adults in Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2010. J Clin Endocrinol Metab 2013;4:1703-1710.
• 10. Dąbrowska-Leonik N., Bernatowska E. Vitamin D and immunity in children. Polish Journal of Paediatrics. 2016;3:251-256.
• 11. Davolio A., Avataneo V., Manca A., Cusato J., De Nicolò D., Lucchini R., Keller F., Cantu F. 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients 2020;12:1359.
• 12. Del Fiol F.D.S., Barberato-Filho S., Lopes L.C., Bergamasch C.D.C. Vitamin D and respiratory infections. J Infect Dev Ctries 2015;9:355-361.
• 13. Deuster E., Jeschke U., Ye Y., Mahner S., Czogalla B. Vitamin D and VDR in gynecological cancers—a systematic review. Int J Mol Sci 2017;18:1-12.
• 14. Di Filippo L, Formenti AM, Rovere-Querini P., Michele Carlucci, Conte C., Ciceri F., Zangrillo A., Giustina A. Hypocalcemia is highly prevalent and predicts hospitalization in patients with COVID-19. Endocrine 2020;68:475-478.
• 15. Dittfeld A., Gwizdek K., Koszowska A., Fizia K. Wielokierunkowe działanie witaminy D [Multidirectional action of vitamin D]. Ann Acad Med Siles 2014;68:47-52 (in Polish).
• 16. Faniyi A.A., Lugg S.T., Faustini S.E. Vitamin D status and seroconversion for COVID-19 in UK healthcare workers who isolated for COVID-19 like symptoms during the 2020 pandemic. MedRxiv 2020;7:1-22
• 17. Fasano A., Cereda E., Barichella M., Cassani E., Ferri V., Aecchinelli L.A., Pezzoli G. COVID-19 in Parkinson’s disease patients living in Lombardy, Italy Mov Disord 2020;35:1089– 93.
• 18. Ferrari D., Locatelli M., Faraldi M., Lombardi G. Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference-An Observational Study from Northern Italy. Biology (Basel) 2021;10:237.
• 19. Ginde A.A., Mansbach J.M., Camargo C.A. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Int Arch Med 2009;169:384-390.
• 20. Goltzman D., Mannstadt M., Marcocci C. Physiology of the calcium-parathyroid hormone-vitamin D axis. Vitamin D in Clinical Medicine. New York, Krager 2018;50:1-13.
• 21. Hackett G., Kirby M. COVID-19, Type 2 Diabetes, and Hypogonadism: Lessons for Acute Management and Long-Term Prevention. Androg Clin Res Ther. 2020;1:22-31.
• 22. Hastie CE, Mackay DF, Ho F. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr Obes. Targets Ther 2020;14:561-565.
• 23. Häusler D., Torke S., Peelen E., Bertsch T., Djukic M., Nau R., Larochelle C., Zamvil S.S, Brück W., Weber M.S. Author NotesHigh dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium. Brain 2019;42: 2737-2755.
• 24. Jankowska K., Suszczewicz N. Naturalne metody wspomagania odporności w walce z koronawirusemc [Natural methods of supporting immunity in the fight against coronavirus]. Wiedza med 2020;30;46-65 (in Polish).
• 25. Jarosz M., Rychlik, E., Stoś K., Charzewska J. (eds): Normy żywienia dla populacji Polski i ich zastosowanie [Nutrition standards for the Polish population]. Narodowy Instytut Zdrowia Publicznego-Państwowy Zakład Higieny. Warsaw, 2020 (in Polish).
• 26. Jiang X., Rayner S., Luo M.H. Does SARS‐CoV‐2 has a longer incubation period than SARS and MERS?. J Med Virol 2020;92: 476-478.
• 27. Kaufman H.W., Niles J.K., Kroll M.H., Bi C., Holick M.F. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS ONE. 2020;15:023925.
• 28. Kmieć P., Sworczak K. Korzyści i zagrożenia wynikające z suplementacji witaminą D [Benefits and risks of vitamin D supplementation]. Endokrynol Polska 2017;1:38-46.
• 29. Lisowska K.A., Bryl E. Rola witaminy D w rozwoju chorób autoimmunologicznych. [The role of vitamin D in the development of autoimmune diseases]. Postepy Hig Med Dosw 2017;71:797-810 (in Polish).
• 30. Luo X., Liao Q., Shen Y., Li H., Cheng L.: Vitamin D deficiency is inversely associated with covid-19 incidence and disease severity in Chinese people, J Nutr 2021;151:98-103.
• 31. Maghbooli Z., Sahraian M.A., Ebrahimi M.: Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PloS one 2020;15:1-13.
• 32. Martineau A.R., Forouhi N.G. Vitamin D for COVID-19: a case to answer?. The Lancet Diab Endocrinol 2020;8:735-736.
• 33. Medrano M., Carrillo-Cruz E., Montero I., Perez- Simon J.A. Vitamin D: effect on haematopoiesis and immune system and clinical applications. Int J Mol Sci 2018;19:1-25.
• 34. Mercola J., Grant W.B., Wagner C.L. Evidence regarding vitamin D and risk of COVID-19 and its severity. Nutrients 2020;12:3361.
• 35. Merzon E., Tworowski D., Gorohovski A., Vinker S., Cohen A.G, Green I., Frenkel-Morgenstern M.. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study. FEBS J 2020; 287:3693-3702.
• 36. Mess E., Pająk W., Ornat M. Spojrzenie na witaminę D w aspekcie chorób nowotworowych [A look at vitamin D in terms of cancer]. Med Paliatyw 2019;11:21-26 (in polish).
• 37. Moozhipurath R.K., Kraft L., Skiera B. Evidence of protective role of Ultraviolet-B (UVB) radiation in reducing COVID-19 deaths. Sci Rep 2020;10:17705.
• 38. Murai I.H., Fernandes A.L., Sales L.P., Pinto A.J., Goessler K.F., et al. (2021). Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial. Jama 2021;325(11):1053-1060.
• 39. Pojednic R.M., Ceglia L., Olsson K. Effects of 1, 25-dihydroxyvitamin D 3 and vitamin D 3 on the expression of the vitamin D receptor in human skeletal muscle cells. Calcif Tissue Int 2015;96:256-263.
• 40. Rastogi A., Bhansali A., Khare N., Suri V., Yaddanapudi N. et al. Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). Postgrad Med J 2020;0:1–4.
• 41. Rhodes J., Dunstan F., Laird E., Subramanian S., Kenny R.A. COVID-19 mortality increases with northerly latitude after adjustment for age suggesting a link with ultraviolet and vitamin D. BMJ Nutr Prev Health 2020;3(1):118-120.
• 42. Rhodes J.M., Subramanian S., Laird E., Griffin G., Kenny R.A. Perspective: Vitamin D deficiency and COVID‐19 severity–plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis. J Intern Med 2020;289:97-115.
• 43. Rusińska A., Płudowski P., Walczak M., Borszewska- Kornacka M.K., Bossowski A., Chlebna-Sokół D., Czech-Kowalska J., Dobrzańska J., Franek E., Helwich E., Jackowska T., Kalina M.A., Konstantynowicz J., Książyk J., Lewiński A., Łukaszkiewicz J., Marcinowska- Suchowierska E., Mazur E., Michałus I., Peregud- Pogorzelski J., Romanowska H., Ruchała M., Socha M., Szalecki M., Wielgoś M., Zwolińska D., Zygmunt A. Vitamin D supplementation guidelines for general population and groups at risk of vitamin D deficiency in Poland—recommendations of the polish society of pediatric endocrinology and diabetes and the expert panel with participation of national specialist consultants and representatives of scientific societies—2018 update.Front Endocrinol 2018;9:246 (in polish).
• 44. Sabetta J.R., DePetrillo P., Cipriani R.J. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PloS one 2010;5:1-8.
• 45. Stefanowski B., Antosik-Wójcińska A., Święcicki Ł. Effect of vitamin D3 deficiency on the severity of depressive symptoms. Psychiatr Pol 2017;51:437-454.
• 46. Stephenson A., Mamo J.C., Takechi R., Hackett M.J., Lam V. Genetic, environmental and biomarker considerations delineating the regulatory effects of vitamin D on central nervous system function. Br J Nutr 2020;1:41-58.
• 47. Sun L., Arbesman J., Piliang M. Vitamin D, autoimmunity and immunerelated adverse events of immune checkpoint inhibitors, Archives of Dermatological Research 2020;313:1-10.
• 48. TNCPERE Team. Vital surveillances: the epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) – China. China CDC Weekly 2020;2:113-122.
• 49. Torabi A., Mohammadbagheri E., Akbari Dilmaghani N., Bayat A.H., Fathi M., Vakili K., Alizadeh R., Rezaeimirghaed O., Hajiesmaeili M., Hajiesmaeili M., Ramezani M., Simani L., Aliaghaei, A. Proinflammatory cytokines in the olfactory mucosa result in COVID-19 induced anosmia. ACS Chem Neurosci 2020;11:1909-1913.
• 50. Ulivieri F.M., Banfi G., Camozzi V., Colao A., Formenti A.M., Frara S., Lombardi G., Napoli N., Giustina A. Vitamin D in the COVID-19 era: a review with recommendations from A GIOSEG expert panel. Endocrine 2021:1-7.
• 51. Uyeki T.M., Mehta A.K., Davey R.T., Liddell A.M. Wolf T., et al. Working Group of the U.S.–European Clinical Network on Clinical Management of Ebola Virus Disease Patients in the U.S. and Europe. Clinical Management of Ebola Virus Disease in the United States and Europe. N Engl J Med 2016;18:636-46.
• 52. Yang X., Yu Y., Xu J. Clinical course and outcomes of critically ill patients with SARSCoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020;8:475-481.

Identyfikatory

DOI

10.32394/rpzh.2022.0191