MiR - 34a regulates apoptosis in liver cells by targeting the KLF4 gene

• Autorzy: Chen Q. , Li L. , Tu Y. , Zheng L. L. , Liu W. , Zuo Y. , He Y. M. , Zhang S. Y. , Zhu W. , Cao J. P. , Cui F. M. , Hou J.
• Języki publikacji: EN

Abstrakty

EN

MicroRNAs (miRNAs) regulate gene expression by inhibiting translation or targeting messenger RNA (mRNA) for degradation in a posttranscriptional fashion. In this study, we show that ectopic expression of miR-34a-5p reduces the mRNA and protein levels of Krüppel-like factor 4 (KLF4). We also demonstrate that miR-34a targets the 3′-untranslated mRNA region of KLF4 and show that overexpression of miR-34a induces a significant level of apoptosis in BNL CL.2 cells exposed to doxorubicin or 10 Gy X-ray. Our data suggest that the effects of miR-34a on apoptosis occur due to the downregulation of KLF4.

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2014
• Tom: 19
• Numer: 1
• Opis fizyczny: p.52-64,fig.,ref.

Twórcy

autor

Chen Q.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Li L.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Tu Y.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Zheng L. L.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Liu W.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Zuo Y.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

He Y. M.

• Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou City, China

autor

Zhang S. Y.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Zhu W.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Cao J. P.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Cui F. M.

• Department of Radiation Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou City, China

autor

Hou J.

• Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai City, China

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