Pharmacokinetics of propofol in rainbow trout following bath exposure

• Autorzy: Gomulka P. , Fornal E. , Berecka B. , Szmagara A. , Ziomek E.
• Języki publikacji: EN

Abstrakty

EN

Propofol, 2,6-diisopropylphenol, seems to be a good candidate as a fish anaesthetic, however, no study regarding propofol influence on fish has yet been reported. The aim of this study was to examine propofol pharmacokinetics in rainbow trout (Oncorhynchus mykiss) following bath exposure. Fish (n = 100) were exposed to an aqueous propofol bath at 12°C and 17°C; propofol concentration in the bath was 10 mg L(-1). Plasma concentration-time profiles were determined using LC-MS, and pharmacokinetic parameters were calculated. Propofol was absorbed quickly at both temperatures. Its concentration reached 13.8 ± 2.7 μg mL(-1) and 16.1 ± 2.1 μg mL(-1) at 12°C and 17°C, respectively, during the first minute of exposure. Blood plasma propofol decreased rapidly to 6.8 ± 0.7 μg mL(-1) and 6.3 ± 2.2 μg mL(-1) at 12°C and 17°C respectively, during the first 10 minutes of the recovery. The half-life time of propofol was 1.5 h and 1.1 h at 12°C and 17°C, respectively. We found propofol anaesthesia in trout effective and safe. However, it caused a gradual decrease of respiratory rate, and therefore a specific anaesthesia protocol should be developed.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2015
• Tom: 18
• Numer: 1
• Opis fizyczny: p.147-152,ref.

Twórcy

autor

Gomulka P.

• Department of Ichthyology, Faculty of Environmental Sciences, University of Warmia and Mazury in OLsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland

autor

Fornal E.

• Laboratory of Separation and Spectroscopic Method Applications, Centre for Interdisciplinary Research, Konstantynow 1F, 20-708 Lublin, Poland

autor

Berecka B.

• Department of Chemistry, Faculty of Environmental Management and Agriculture, Pl. Lodzki 4, 10-719 Olsztyn, Poland

autor

Szmagara A.

• Chemistry Department, The John Paul II Catholic University of Lublin, Krasnicka 102, 20-718 Lublin, Poland

autor

Ziomek E.

• Department of Ichthyology, Faculty of Environmental Sciences, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland

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Identyfikatory

DOI

10.1515/pjvs-2015-0019