Plasma profile of cimicoxib in sheep after oral administration at two different rates

• Autorzy: Di Salvo A. , Giorgi M. , Lee H.K. , Vercelli C. , Rueca F. , Trabalza Marinucci M. , della Rocca G.
• Języki publikacji: EN

Abstrakty

EN

Sheep are often subjected to painful procedures and thus they need to be treated with analgesics. Nevertheless, knowledges about pharmacokinetic features of these drugs in this species are poor. The aim of this study was to evaluate plasma behaviour of cimicoxib in sheep after a single oral administration at two different dose rates (4 and 6 mg/kg). Maximum plasma concentrations of cimicoxib were equal to 273.78 (median value; range 189.00-567.32) and 565.01 (range 308.27-822.59) ng/mL after treatment with 4 and 6 mg/kg, respectively. The time of maximum concentration (Tmax) was achieved between 4 and 10 hours following treatment at the lower dose, and between 6 and 10 hours after the administration of the higher dose, with one sheep achieving the concentration peak at 0.75 hours. The slow absorption and the great individual variability in plasma concentration, probably due to ruminal effects, suggest that cimicoxib is not suitable for oral treatment in sheep.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2017
• Tom: 20
• Numer: 3
• Opis fizyczny: p.535-538,fig.,ref.

Twórcy

autor

Di Salvo A.

• Department of Veterinary Medicine, University of Perugia, Perugia, Italy

autor

Giorgi M.

• Department of Veterinary Medicine, University of Pisa, Pisa, Italy

autor

Lee H.K.

• Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam University, Daejon, South Korea

autor

Vercelli C.

• Department of Veterinary Sciences, University of Torino, Grugliasco, Torino, Italy

autor

Rueca F.

• Department of Veterinary Medicine, University of Perugia, Perugia, Italy

autor

Trabalza Marinucci M.

autor

della Rocca G.

• Department of Veterinary Medicine, University of Perugia, Perugia, Italy

Bibliografia

• Baggot JD, Brown SA (1998) Basis for selection of the dosage form. In: Hardee GE, Baggot JD (eds) Development and Formulation of Veterinary Dosage Forms, 2nd ed., Marcel Dekker Inc, New York, pp 7-143.
• Coulter CA, Flecknell PA, Richardson CA (2009) Reported analgesic administration to rabbits, pigs, sheep, dogs and non-human primates undergoing experimental surgical procedures. Lab Anim 43: 232-238.
• EMA, (2011). European Medicine Agency. Cimalgex: EPAR – Public assessment report. EMA/CVMP/513842/ 2011.
• Giorgi M, Kim TW, Saba A, Rouini M-R, Yun H, Ryschanova R, Owen H (2013) Detection and quantification of cimicoxib, a novel COX-2 inhibitor, in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology. J Pharm Biomed Anal 83: 28-33.
• Harirforoosh S, Asghar W, Jamali F (2013) Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci 16: 821-847.
• Kim TW, Della Rocca G, Di Salvo A, Owen H, Sgorbini M, Giorgi M (2014) Pharmacokinetics of the Novel Cyclooxygenase 2 Inhibitor Cimicoxib in Donkeys. J Equine Vet Sci 34: 923-925.
• Kim TW, Della Rocca G, Di Salvo A, Ryschanova R, Sgorbini M, Giorgi M (2015) Evaluation of pharmacokinetic and pharmacodynamic properties of cimicoxib in fasted and fed horses. N Z Vet J 63: 92-97.
• Lees P, Taylor JB, Higgins AJ, Sedgwick AD (1988a) In vitro and in vivo binding of phenylbutazone and related drugs to equine feeds and digesta. Res Vet Sci 44: 50-56.
• Lees P, Ayliffe T, Maitho TE, Taylor JB (1988b) Pharmacokinetics, metabolism and excretion of phenylbutazone in cattle following intravenous, intramuscular and oral administration. Res Vet Sci 44: 57-67.
• Marini D, Pippia J, Colditz IG, Hinch G, Petherick JC, Lee C (2015) Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. Aust Vet J 93: 265-270.
• Small AH, Belson S, Holm M, Colditz IG (2014) Efficacy of a buccal meloxicam formulation for pain relief in Merino lambs undergoing knife castration and tail docking in a randomised field trial. Aust Vet J 92: 381-388.
• Stock ML, Coetzee JF, KuKanich B, Smith BI (2013) Pharmacokinetics of intravenously and orally administered meloxicam in sheep. Am J Vet Res 74: 779-783.
• Stubsjøen SM, Flø AS, Moe RO, Janczak AM, Skjerve E, Valle PS, Zanella AJ (2009) Exploring non-invasive methods to assess pain in sheep. Physiol Behav 98: 640-648.
• Toutain PL, Bousquet-Mélou A (2004) Bioavailability and its assessment. J Vet Pharmacol Ther 27: 455-466.
• Welsh EM, Nolan AM (1995) Effect of flunixin meglumine on the thresholds to mechanical stimulation in healthy and lame sheep. Res Vet Sci 58: 61-66.

Identyfikatory

DOI

10.1515/pjvs-2017-0065