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2009 | 69 | 3 |
Tytuł artykułu

Monocular enucleation induces prominent thymosin beta4 expression in microglia and neurons of the superior colliculus of adult mice

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Thymosin beta 4 (Tβ4) is a peptide of 43 amino acids, mainly recognized as a regulator of actin polymerisation by sequestering Gactin. The peptide has been implicated in apoptosis, angiogenesis and lesion-induced neuroplasticity. Tβ4 is widely distributed in the brain, in neurons as well as in microglia. In this study we examined possible changes in Tβ4 expression in the visual system of the mouse after surgical removal of one eye. Adult mice were deprived of vision and sacrifi ced 1, 3 and 5 days and 1, 2 and 7 weeks after enucleation of the right eye. After 3 days of monocular deprivation, a substantial up-regulation of Tβ4-positive microglia was visible in the left superior colliculus, which faded with post-lesion survival time. The Tβ4-positive microglia appeared activated for clearance of debris of degenerating axons and myelin. Apart from this microglial activation, a remarkable neuronal response was observed. In the deeper layers of the left and right superior colliculus Tβ4- positive neurons with very long Tβ4-positive neurites became apparent. These cells were visible within 1 week but became more obvious 7 weeks post-lesion. Tβ4 may therefore participate in growth or remodeling of neuronal processes in deep layers of the superior colliculus possibly to induce some form of recovery of the visual system upon sensory deprivation.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.336
Twórcy
autor
  • Laboratory of Neuroplasticity and Neuroproteomics, K.U. Leuven, Leuven, The Netherlands
autor
  • Laboratory of Neuroplasticity and Neuroproteomics, K.U. Leuven, Leuven, The Netherlands
autor
  • Laboratory of Neuroplasticity and Neuroproteomics, K.U. Leuven, Leuven, The Netherlands
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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