Large granular lymphoma in six cats

• Autorzy: Sapierzynski R. , Jankowska U. , Jagielski D. , Kliczkowska-Klarowicz K.
• Języki publikacji: EN

Abstrakty

EN

Large granular lymphomas (LGLs) comprise a specific group of lymphomas regardless of classification scheme. An LGL consists of cells that show less or more mature morphology, but typically neoplastic cells possess cytoplasmic azurophilic granules clearly visible during cytological examination. The aim of the present study was to present clinical and cytological data on large granular lymphomas in cats and to analyses the therapeutic responses in treated cases. During the period from 2012 to 2014 six cats were as having large granular lymphoma. In one cat a nasal form of LGL was recognized, a systemic form was recognized in another cat, and in four cases an alimentary form was recognized. Cellular samples for cytopathology were collected from the cat with nasal cavity mass, from the enlarged mandibular lymph node and thoracic cavity from second cat, and in four cats from the abdominal mass during ultrasound-assisted fine-needle biopsy. Therapy was introduced in 5 of the 6 cats. In two cases palliative therapy with glucocorticoids was conducted, in two cases chemotherapy with COP protocol, and therapy with masitinib in one case. The median of survival time for cats treated with anticancer therapy was 9 months, the median of survival time for cats treated with glucocorticoids was 1.5 months. In conclusion, large granular lymphomas, especially the alimentary form, are a relatively common type of lymphoma in cats. Simple diagnostic methods such as clinical examination, imaging techniques and routine cytology are sufficient in majority of cases. Despite aggressive behavior and poor general prognosis, conventional chemotherapy lead to a good response in some treated cats regardless of anatomic form and histologic grade of malignancy.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2015
• Tom: 18
• Numer: 1
• Opis fizyczny: p.163-169,ref.

Twórcy

autor

Sapierzynski R.

• Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02-766 Warsaw, Poland

autor

Jankowska U.

• Białobrzeska Veterinary Surgery in Warsaw, Warsaw, Poland

autor

Jagielski D.

• Białobrzeska Veterinary Surgery in Warsaw, Warsaw, Poland

autor

Kliczkowska-Klarowicz K.

• Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02-766 Warsaw, Poland

Bibliografia

• Aitken-Palmer C, Isaza R, Dunbar M, Blackwood S, Gerlach T, Russell K (2011) Anterior uveitis as an atypical presentation of large granular lymphoma in a caracal (Caracal caracal). Vet Ophthalmol 14: 337-340.
• Chino J, Fujino Y, Kobayashi T, Kariya K, Goto-Koshino Y, Ohno K, Nakayama H, Tsujimoto H (2013) Cytomorphological and immunological classification of feline lymphomas: clinicopathological features of 76 cases. J Vet Med Sci 75: 701-707.
• Darbes J, Majzoub M, Breuer W, Hermanns W (1998) Large granular lymphocyte leukemia/lymphoma in six cats. Vet Pathol 35: 370-379.
• Endo Y, Cho KW, Nishigaki K, Momoi Y, Nishimura Y, Mizuno T, Goto Y, Watari T, Tsujimoto H, Hasegawa A (1998) Clinicopathological and immunological characteristics of six cats with granular lymphocyte tumors. Comp Immunol Microbiol Infect Dis 21: 27-42.
• Franks PT, Harvey JW, Calderwood Mays M, Senior DF, Bowen DJ, Hall BJ (1986) Feline large granular lymphoma. Vet Pathol 23: 200-202.
• Kariya K, Konno A, Ishida T (1997) Perforin-like im-munoreactivity in four cases of lymphoma of large granular lymphocytes in the cat. Vet Pathol 34: 156-159.
• Krick EL, Little L, Patel R, Shofer FS, Sorenmo K, Clifford CA, Baez JL (2008) Description of clinical and pathological findings, treatment and outcome of feline large granular lymphocyte lymphoma (1996-2004). Vet Comp Oncol 6: 102-110.
• Moore PF, Rodriguez-Bertos A, Kass PH (2012) Feline gastrointestinal lymphoma: mucosal architecture, immunophenotype, and molecular clonality. Vet Pathol 49: 658-668.
• Neta M, Naigamwalla D, Bienzle D (2008) Perforin expression in feline epitheliotropic cutaneous lymphoma. J Vet Diagn Invest 20: 831-835.
• Pohlman LM, Higginbotham ML, Welles EG, Johnson CM (2009) Immunophenotypic and histologic classification of 50 cases of feline gastrointestinal lymphoma. Vet Pathol 46: 259-268.
• Roccabianca P, Vernau W, Caniatti M, Moore PF (2006) Feline large granular lymphocyte (LGL) lymphoma with secondary leukemia: primary intestinal origin with predominance of a CD3/CD8 aa phenotype. Vet Pathol 43: 15-28.
• Tsuboi M, Uchida K, Park ES, Kotera Y, Seki T, Takahashi M, Nakayama H (2010) Systemic T cell large granular lymphocyte lymphoma with multifocal white matter degeneration in the brain of a Japanese domestic cat. J Vet Med Sci 72: 795-799.
• Wellman ML, Hammer AS, DiBartola SP, Carothers MA, Kociba GJ, Rojko JL (1992) Lymphoma involving large granular lymphocytes in cats: 11 cases (1982-1991). J Am Vet Med Assoc 201: 1265-1269.

Identyfikatory

DOI

10.1515/pjvs-2015-002