The isoform- and location-dependence of the functioning of the plasma membrane calcium pump

• Autorzy: Zylinska L. , Kawecka I. , Lachowicz L. , Szemraj J.
• Języki publikacji: EN

Abstrakty

EN

The plasma membrane is a specialised multi-component structure with inter- and intracellular signalling functions. Ca2+ plays a crucial role in cellular physiology, and an ATP-driven plasma membrane calcium pump (PMCA) plays the greatest role in the maintenance of a low free Ca2+ concentration in the cytoplasm. The enzyme is coded by four separate genes (PMCA 1-4), and, due to alternative splicing, more than 20 variants can exist. PMCA 1 and 4 isoforms are present in almost all tissues, whereas PMCA 2 and 3 are found in more specialised cell types. The variants differ primarily in their regulatory regions, thus the modulation of calcium pump activity strongly depends on the isoform and the membrane composition. The unique function of PMCA isoforms was confirmed using the practical experimental models - a rat pheochromocytoma cell line, a human neuroblastoma cell line, or, more recently, knockout mice. In addition, based on the finding that PMCA could interact with several specific signaling proteins, it was concluded that its location in defined sites of the cell membrane could be a prerequisite for efficient intercellular communication.

Słowa kluczowe

EN

isoform; calcium; plasma membrane; calcium pump; uptake; antisense oligonucleotide; regulation

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2002
• Tom: 07
• Numer: 4
• Opis fizyczny: p.1037-1045,fig.,ref.

Twórcy

autor

Zylinska L.

• Neurochemical Laboratory, Department of Biochemistry, Medical University, Mazowiecka 6/8, 92-215 Lodz, Poland

autor

Kawecka I.

• Neurochemical Laboratory, Department of Biochemistry, Medical University, Mazowiecka 6/8, 92-215 Lodz, Poland

autor

Lachowicz L.

• Neurochemical Laboratory, Department of Biochemistry, Medical University, Mazowiecka 6/8, 92-215 Lodz, Poland

autor

Szemraj J.

• Neurochemical Laboratory, Department of Biochemistry, Medical University, Mazowiecka 6/8, 92-215 Lodz, Poland

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