Inhibition of mGluR1 and mGluR5 impairs memory consolidation and reconsolidation by disregulation of local protein synthesis

• Autorzy: Slomka M. , Lenart J. , Salinska E.
• Języki publikacji: EN

Abstrakty

EN

It is known that mGluRs group I (mGluR1 and mGluR5) are involved in memory consolidation and reconsolidation probably by local protein synthesis regulation. One of the consequences of group I mGluRs activation is the synthesis of new proteins that play important role in memory consolidation and reconsolidation – NCAM and CaMKII, and also FMRP, that plays an important role in the mRNA transport and regulation of mRNA translation in the nerve endings by a negative-feedback mechanism. The aim of this study was to investigate the effect of mGluR1 and mGluR5 inhibition on synthesis of NCAM, CaMKII and the regulatory protein FMRP. In our experiments the passive avoidance task in one-day chicks was used and mGluRs 1/5 were inhibited by intracerebral injection of specific inhibitors, LY367385 and MPEP respectively. The expression of chosen proteins was determined in nerve endings isolated from chick brain. Our results show, that inhibition of each receptor around the time of training resulted in decrease of NCAM and CaMKII synthesis, as well as in synthesis of FMRP. However, the inhibition of mGluR1/5 around the time of reminder resulted in increase in NCAM and CaMKII synthesis, although synthesis of FMRP was significantly decreased. These results suggest that both receptors are involved in memory formation by regulation of termination of protein synthesis through control of FMRP synthesis.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: Suppl.1
• Opis fizyczny: p.28-29

Twórcy

autor

Slomka M.

• Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Lenart J.

• Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Salinska E.

• Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland