Biocatalytic synthesis of delta - gluconolactone and eta - caprolactone copolymers

• Autorzy: Todea A. , Badea V. , Nagy L. , Keki S. , Boeriu C. G. , Peter F.
• Języki publikacji: EN

Abstrakty

EN

 The biodegradability and biocompatibility properties of ε-caprolactone homopolymers place it as a valuable raw material, particularly for controlled drug delivery and tissue engineering applications. However, the usefulness of such materials is limited by their low hydrophilicity and slow biodegradation rate. In order to improve polycaprolactone properties and functionalities, copolymerization of ε-caprolactone with δ-gluconolactone was investigated. Since enzymatic reactions involving sugars are usually hindered by the low solubility of these compounds in common organic solvents, finding the best reaction medium was a major objective of this research. The optimal copolymerization conditions were set up by using different organic media (solvent and solvents mixtures), as well as solvent free systems that are able to dissolve (completely or partially) sugars, and are nontoxic for enzymes. Native and immobilized lipases by different immobilization techniques from Candida antarctica B and Thermomyces lanuginosus have been used as biocatalyst at 80°C. Although the main copolymer amount was synthesized in DMSO:t-BuOH (20:80) medium, the highest polymerization degrees, up to 16 for the copolymer product, were achieved in solventless conditions. The products, cyclic and linear polyesters, have been characterized by FT-IR and MALDI-TOF MS analysis. The reaction product analysis revealed the formation of cyclic products that could be the major impediment of further increase of the chain length.

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2014
• Tom: 61
• Numer: 2
• Opis fizyczny: p.205-210,fig.,ref.

Twórcy

autor

Todea A.

• Faculty of Industrial Chemistry and Environmental Engineering, University “Politehnica” of Timisoara, Timisoara, Romania

autor

Badea V.

• Faculty of Industrial Chemistry and Environmental Engineering, University “Politehnica” of Timisoara, Timisoara, Romania

autor

Nagy L.

• Department of Applied Chemistry, University of Debrecen, Debrecen, Hungary

autor

Keki S.

• Department of Applied Chemistry, University of Debrecen, Debrecen, Hungary

autor

Boeriu C. G.

• Wageningen UR Food & Biobased Research, Wageningen, The Netherlands

autor

Peter F.

• Faculty of Industrial Chemistry and Environmental Engineering, University “Politehnica” of Timisoara, Timisoara, Romania

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