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2014 | 60 | 2 |
Tytuł artykułu

The role of toll-like receptor agonists in the immunotherapy of leishmaniosis. An update and proposal for a new form of anti-leishmanial therapy

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The use of toll-like receptor agonists in immunotherapy is a new approach in the prevention of immunosuppression during fatal Leishmania parasite infection. The objective of such immunotherapy is to activate specific cell-mediated immune responses, macrophage activation and antigen-responsive inflammation, to kill intracellular amastigotes. Toll-like receptor agonist-based treatment in immunocompetent hosts can be effective either by selective use of the agonists alone or in combination with the anti-leishmanial drug stibanate. Recent investigations suggest that toll-like receptor signal pathways constitute a possible new mode of anti-leishmanial treatment. This article describes the prospect of toll-like receptor – mediated signal pathways in the immunotherapy of cutaneous and visceral leishmaniosis, as well as post kala-azar dermal leishmaniosis (PKADL), a skin-sequel of visceral infection. Suitable synthetic agonists need to be developed for toll-like receptors to overcome immunosuppression.
Wydawca
-
Rocznik
Tom
60
Numer
2
Opis fizyczny
p.75-82,fig.,ref.
Twórcy
autor
  • Department of Microbiology and Immunology, Saint James School of Medicine (Anguilla Campus), Albert Lake Drive, The Quarter, A-I-2640, P.O.Box 318, Anguilla
  • Department of Microbiology and Immunology, Saint James School of Medicine (Anguilla Campus), Albert Lake Drive, The Quarter, A-I-2640, P.O.Box 318, Anguilla
  • Storm Eye Institute, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425, USA
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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