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2009 | 69 | 3 |
Tytuł artykułu

Stressor effects on IL-10 and IFN-gamma production are mediated by betta-adrenergic and glucocortiocid receptors and attenuated by chlordiazepoxide

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Research indicates that psychological stress can modulate immune responses. Here we demonstrate that restraint stress suppresses interferon (IFN)-γ production and signalling in mice following in vivo lipopolysaccharide (LPS) treatment. Stress also suppressed production of the IFN-γ inducing cytokine interleukin (IL)-12 and increased production of the anti-infl ammatory cytokine IL-10, which can inhibit both IL-12 and IFN-γ production. Studies with IL-10 knockout mice demonstrate that IL-10 does not mediate the suppressive effect of stress on IFN-γ production. Consistent with a role for glucocorticoids in the immunosuppressive actions of stress, the glucocorticoid receptor antagonist mifepristone blocked the stress-related suppression of IFN-γ. In contrast, the stress-induced increase in IL-10 was blocked by the beta-adrenergic receptor antagonist nadolol. Addition of IL-12 to LPS-stimulated spleen cells reversed the suppressive effect of stress and corticosterone on IFN-γ production, suggesting that reduced IL-12 production is a key event in stress-induced suppression of IFN-γ production. Finally, we demonstrate that treatment with the anxiolytic drug chlordiazepoxide prevents the ability of stress to increase IL-10 and suppress IFN-γ production.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.281
Twórcy
autor
  • Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
autor
  • Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
autor
  • Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
autor
  • School of Biochemistry and Immunology, Trinity College Dublin, Ireland
autor
  • Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-3d3303a6-0149-4b62-81a5-87a126f71562
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