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2009 | 69 | 3 |
Tytuł artykułu

Stress-induced changes in gene expression of catecholamine enzymes and adrenoceptors in heart of sham-operated and PVN-deafferentated rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The paraventricular nucleus of the hypothalamus (PVN) regulates neuroendocrine, autonomic and cardiovascular responses to stress. Stressors activate catacholaminergic systems which consequently modulates activity of organism via adrenergic receptors (ARs). Our work was focused on investigation of changes in gene expression of epinephrine-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT), neuropeptide Y (NPY) and adrenoceptors in the heart of sham-operated and PVN-deafferentated rats exposed to immobilization stress (IMO). PNMT and NPY mRNA levels in the heart of sham-operated rats were not signifi cantly increased after a single IMO. However, posterolateral deafferentation of the PVN reduced PNMT mRNA, whereas levels of NPY mRNA were elevated. These data suggest a stimulatory role of PVN on PNMT and an inhibitory role on NPY gene expression. Moreover, β1-AR mRNA levels were signifi cantly reduced in heart of PVN-deafferentated animals comparing to sham-operated rats. On other side, after single IMO β1-AR mRNA levels were signifi cantly increased in PVN-deafferentated rats. Gene expression of other ARs (β2, β3, α1B) in hearts of stressed PVN-deafferentated animals were decreased. The found down-regulation of gene expression of ARs might suggest a rise in sympathetic activity induced by PVN deafferentation. Our data suggest that PVN plays an important role in stress-induced activation of cardiac sympathetic system.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.357
Twórcy
autor
  • Laboratory of Stress Research, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
autor
  • Laboratory of Functional Morphology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
autor
  • Laboratory of Stress Research, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
  • Laboratory of Stress Research, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-3b691501-cab6-430e-ba2c-6f713989f5a3
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