Antidepressant-and anxiolytic-like properties of ADN-1319, a new analogue of aripiprazole

• Autorzy: Wasik A. , Partyka A. , Jastrzebska-Wesek M. , Kolaczkowski M. , Pawlowski M. , Wesolowska A.
• Języki publikacji: EN

Abstrakty

EN

ADN-1319 is a new indoloamine analogue of aripiprazole which displays antipsychotic-like properties in mouse models of psychosis, i.e. MK-801- and amphetamine-induced locomotor hyperactivity. In order to examine its potential antidepressant and anxiolytic activity, the forced swim test, and the four-plate and the marble burying tests, respectively, in mice were performed and a minimum effective dose is presented. ADN-1319 (2.5 mg/kg) significantly decreased the immobility time. Moreover, it increased the number of punished crossings (5 mg/kg) and reduced (10 mg/kg) the number of buried marbles. ADN-1319 up to a dose of 10 mg/kg had no influence on spontaneous locomotor activity in mice. Obtained data suggest that the tested compound displays specific antidepressant- and anxiolyticlike properties in mice and might find an application in treatment of symptoms of depression, anxiety or obsessive–compulsive behavior concomitant in schizophrenia.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.362

Twórcy

autor

Wasik A.

• Department of Clinical Pharmacy, Jagiellonian University Medical College, Cracow, Poland

autor

Partyka A.

• Department of Clinical Pharmacy, Jagiellonian University Medical College, Cracow, Poland

autor

Jastrzebska-Wesek M.

• Department of Clinical Pharmacy, Jagiellonian University Medical College, Cracow, Poland

autor

Kolaczkowski M.

• Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, Cracow, Poland

autor

Pawlowski M.

• Department of Pharmaceutical Chemistry, Jagiellonian University Medical College, Cracow, Poland

autor

Wesolowska A.

• Department of Clinical Pharmacy, Jagiellonian University Medical College, Cracow, Poland