Penicillin resistance in Enterococcus faecalis: molecular determinants and epidemiology

• Autorzy: Gawryszewska I. , Hryniewicz W. , Sadowy E.
• Języki publikacji: EN

Abstrakty

EN

Enterococcus faecalis plays a significant role in hospital-acquired infections (HAIs), and combination of penicillin with aminoglycoside is important in therapy of invasive HAIs. Penicillin resistance in this organism is due to modification of the drug target, penicillin-binding protein (PBP5), its overproduction and expression of β-lactamase. Although rare, this phenotype is often associated with multi-resistant high-risk enterococcal clonal complexes (HiRECCs), such as CC2 and CC9 which may promote its spread in the near future.

Słowa kluczowe

EN

penicillin; resistance; Enterococcus faecalis; molecular determinant; epidemiology; beta-lactamase; human infection

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2012
• Tom: 61
• Numer: 3
• Opis fizyczny: p.153-160,ref.

Twórcy

autor

Gawryszewska I.

• Department of Molecular Microbiology, National Medicines Institute, ul. Chełmska 30/34, 00-725 Warsaw, Poland

autor

Hryniewicz W.

autor

Sadowy E.

Bibliografia

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