PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2009 | 69 | 1 |

Tytuł artykułu

Challenges and possibilities of intravascular cell therapy in stroke

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Stroke is the third leading cause of death in Western countries and more importantly a leading cause of adult disability. The recovery process of stroke patients might be enhanced by intensive rehabilitation, which acts through brain plasticity mechanisms. Restorative approaches such as cell-based therapies are clinically appealing as it might be possible to help patients even when treatment is initiated days or weeks after the ischemic insult. An extensive number of experimental transplantation studies have been conducted with cells of different origins (e.g., embryonic stem, fetal neural stem, human umbilical cord blood) with promising results. Noninvasive intravascular administration of cells, which provides a broad distribution of cells to the close proximity of ischemic tissue, has perhaps the most immediate access to clinical applications. However, surprisingly little is known about whole body biodistribution of intravascularly administered cells and mechanisms leading to improved functional recovery. This review examines the recent literature concerning intravascular cell-based therapies in experimental stroke.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

69

Numer

1

Opis fizyczny

p.1-10,fig.,ref.

Twórcy

autor
  • Department of Neurology, University of Kuopio, Kuopio, Finland
autor
  • Department of Neurology, University of Kuopio, Kuopio, Finland

Bibliografia

  • Aicher A, Brenner W, Zuhayra M, Badorff C, Massoudi S, Assmus B, Eckey T, Henze E, Zeiher AM, Dimmeler S (2003) Assessment of the tissue distribution of trans­planted human endothelial progenitor cells by radioactive labeling. Circulation 107: 2134-2139.
  • Bacigaluppi M, Pluchino S, Martino G, Kilic E, Hermann DM (2008) Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci 265: 73-77.
  • Bang OY, Lee JS, Lee PH, Lee G (2005) Autologous mesen­chymal stem cell transplantation in stroke patients. Ann Neurol 57: 874-882.
  • Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM (2001) Why are stroke patients excluded from TPA thera­py? An analysis of patient eligibility. Neurology 56: 1015-1020.
  • Borlongan CV, Hadman M, Sanberg CD, Sanberg PR (2004) Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotec­tion in stroke. Stroke 35: 2385-2389.
  • Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, Sanchez-Ramos J, Chopp M (2001a) Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32: 2682­2688.
  • Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M (2001b) Therapeutic benefit of intravenous administra­tion of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32: 1005-1011.
  • Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, Lu M, Zhu Z, Chopp M (2003) Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 92: 692-699.
  • Chen J, Li Y, Zhang R, Katakowski M, Gautam SC, Xu Y, Lu M, Zhang Z, Chopp M (2004) Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neuro­genesis. Brain Res 1005: 21-28.
  • Chen X, Li Y, Wang L, Katakowski M, Zhang L, Chen J, Xu Y, Gautam SC, Chopp M (2002) Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 22: 275-279.
  • Chu K, Kim M, Park KI, Jeong SW, Park HK, Jung KH, Lee ST, Kang L, Lee K, Park DK, Kim SU, Roh JK (2004) Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia. Brain Res 1016: 145-153.
  • Cui X, Chen J, Zacharek A, Roberts C, Savant-Bhonsale S, Chopp M (2008) Treatment of stroke with (Z)-1-[N-(2- aminoethyl)-N-(2-ammonioethyl) amino] diazen-1- ium-1, 2-diolate and bone marrow stromal cells upregu- lates angiopoietin-1/Tie2 and enhances neovasculariza­tion. Neuroscience 156: 155-164.
  • Esneault E, Pacary E, Eddi D, Freret T, Tixier E, Toutain J, Touzani O, Schumann-Bard P, Petit E, Roussel S, Bernaudin M (2008) Combined therapeutic strategy using erythropoietin and mesenchymal stem cells potentiates neurogenesis after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 28: 1552-1563.
  • Gao J, Dennis JE, Muzic RF, Lundberg M, Caplan AI (2001) The dynamic in vivo distribution of bone marrow-derived mesen­chymal stem cells after infusion. Cell Tiss Org 169: 12-20.
  • Grabowski M, Sorensen JC, Mattsson B, Zimmer J, Johansson BB (1995) Influence of an enriched environ­ment and cortical grafting on functional outcome in brain infarcts of adult rats. Exp Neurol 133: 96-102.
  • Guzman R, De Los Angeles A, Cheshier S, Choi R, Hoang S, Liauw J, Schaar B, Steiberg G (2008a) Intracarotid injection of fluorescence activated cell-sorted CD49d- positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model. Stroke 39: 1300-1306.
  • Guzman R, Choi R, Gera A, De Los Angeles A, Andres RH, Steinberg GK (2008b) Intravascular cell replacement therapy for stroke. Neurosurg Focus 24: E15.
  • Honma T, Honmou O, Iihoshi S, Harada K, Houkin K, Hamada H, Kocsis JD (2006) Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Exp Neurol 199: 56-66.
  • Horita Y, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD (2006) Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cere­bral ischemia model in the adult rat. J Neurosci Res 84: 1495-1504.
  • Iihoshi S, Honmou O, Houkin K, Hashi K, Kocsis JD (2004) A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res 1007: 1-9.
  • Jiang L, Newman M, Saporta S, Chen N, Sanberg PR, Willing AE (2008) MIP-1alpha and MCP-1 induce migra­tion of human umbilical cord blood cells in models of stroke. Curr Neurovasc Res 5: 118-124.
  • Jin K, Sun Y, Xie L, Mao XO, Childs J, Peel A, Logvinova A, Banwait S, Greenberg DA (2005) Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous trans­plantation in the rat. Neurobiol Dis 18: 366-374.
  • Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn KR, Gebel J, Jannetta P, DeCesare S, Elder EM, McGrogan M, Reitman MA, Bynum L (2000) Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55: 565-569.
  • Kondziolka D, Steinberg GK, Wechsler L, Meltzer CC, Elder E, Gebel J, Decesare S, Jovin T, Zafonte R, Lebowitz J,
  • Flickinger JC, Tong D, Marks MP, Jamieson C, Luu D, Bell-Stephens T, Teraoka J (2005) Neurotransplantation for patients with subcortical motor stroke: a phase 2 ran­domized trial. J Neurosurg 103: 38-45.
  • Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ (2005) Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 23: 879­894.
  • Lappalainen RS, Narkilahti S, Huhtala T, Liimatainen T, Suuronen T, Närvänen A, Suuronen R, Hovatta O, Jolkkonen J (2008) The SPECT imaging shows the accu­mulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats. Neurosci Lett 440: 246-250.
  • Manoonkitiwongsa PS, Schultz RL, McCreery DB, Whitter EF, Lyden PD (2004) Neuroprotection of ischemic brain by vascular endothelial growth factor is critically depen­dent on proper dosage and may be compromised by angiogenesis. J Cereb Blood Flow Metab 24: 693-702.
  • Mäkinen S, Kekarainen T, Nysted J, Liimatainen T, Huhtala T, Närvänen A, Laine J, Jolkkonen J (2006) Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats. Brain Res 1123: 207-217.
  • Newcomb JD, Ajmo CT Jr, Sanberg CD, Sanberg PR, Pennypacker KR, Willing AE (2006) Timing of cord blood treatment after experimental stroke determines therapeutic efficacy. Cell Transplant 15: 213-223.
  • Newman MB, Willing AE, Manresa JJ, Davis-Sanberg C, Sanberg PR (2005) Stroke-induced migration of human umbilical cord blood cells: time course and cytokines. Stem Cells Dev 14: 576-586.
  • Nomura T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD (2005) I.V. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Neuroscience 36: 161-169.
  • Nystedt J, Mäkinen S, Laine J, Jolkkonen J (2006) Human cord blood CD34+ cells and behavioral recovery follow­ing focal cerebral ischemia in rats. Acta Neurobiol Exp (Wars) 66: 293-300.
  • Sacco RL, Adams R, Albers G, Alberts MJ, Benavente O, Furie K, Goldstein LB, Gorelick P, Halperin J, Harbaugh R, Johnston SC, Katzan I, Kelly-Hayes M, Kenton EJ, Marks M, Schwamm LH, Tomsick T; American Heart Association/American Stroke Association Council on Stroke; Council on Cardiovascular Radiology and
  • Intervention; American Academy of Neurology (2006) Guidelines for prevention of stroke in patients with isch­emic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Circulation 113: e409-449.
  • Sanberg PR, Willing AE, Garbuzova-Davis S, Saporta S, Liu G, Sanberg CD, Bickford PC, Klasko SK, El-Badri NS (2005) Umbilical cord blood-derived stem cells and brain repair. Ann N Y Acad Sci 1049: 67-83.
  • Shen LH, Li Y, Chen J, Zhang J, Vanguri P, Borneman J, Chopp M (2006) Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience 137: 393-399.
  • Shen LH, Li Y, Chen J, Zacharek A, Gao Q, Kapke A, Lu M, Raginski K, Vanguri P, Smith A, Chopp M (2007a) Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 27: 6-3.
  • Shen LH, Li Y, Chen J, Cui Y, Zhang C, Kapke A, Lu M, Savant-Bhonsale S, Chopp M (2007b) One-year follow- up after bone marrow stromal cell treatment in middle- aged female rats with stroke. Stroke 38: 2150-2156.
  • Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski WW, Emeribe U; SAINT II Trial Investigators (2007) NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 357: 562-571.
  • Vendrame M, Cassady J, Newcomb J, Butler T, Pennypacker KR, Zigova T, Sanberg CD, Sanberg PR, Willing AE (2004) Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral defi­cits and reduces infarct volume. Stroke 35: 2390-2395.
  • Vendrame M, Gemma C, de Mesquita D, Collier L, Bickford PC, Sanberg CD, Sanberg PR, Pennypacker KR, Willing AE (2005) Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev 14: 595-604.
  • Vilalta M, Dégano IR, Bagó J, Gould D, Santos M, García- Arranz M, Ayats R, Fuster C, Chernajovsky Y, García- Olmo D, Rubio N, Blanco J (2008) Biodistribution, long- term survival, and safety of human adipose tissue-derived mesenchymal stem cells transplanted in nude mice by high sensitivity non-invasive bioluminescence imaging. Stem Cells Dev 17: 993-1003.
  • Vora N, Jovin T, Kondziolka D (2006) Cell transplantation for ischemic stroke, Neurodegener Dis 3: 101-105.
  • Walczak P, Zhang J, Gilad AA, Kedziorek DA, Ruiz-Cabelo J, Young RG, Pittenger MF, van Zijl PCM, Huang J, Bulte JWM (2008) Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke 39: 1569-1574.
  • Willing AE, Lixian J, Milliken M, Poulos S, Zigova T, Song S, Hart C, Sanchez-Ramos J, Sanberg PR (2003) Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res 73: 296­307.

Uwagi

PL
Rekord w opracowaniu

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-2ff79589-5f50-423b-8cba-0db3930cd948
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.