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2009 | 69 | 3 |
Tytuł artykułu

Matrix metalloproteinasa-9 increases NMDA receptor lateral diffusion

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of NMDA receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by which MMP-9 affects NMDAR signaling remain, however, not well understood. Using single Quantum Dot tracking we demonstrate that MMP-9 enzymatic activity increases NR1-NMDAR surface traffi cking but has no infl uence on AMPA receptor (AMPAR) mobility. Other extracellular protease – Cathepsin G has no effect on both NMDAR and AMPAR lateral diffusion. The mechanism of MMP-9 action on NMDAR is caused neither by change in overall extracellular matrix (ECM) structure, nor by cleavage of NMDAR subunits, but by infl uence on integrinbeta 1 signaling. These fi ndings describe a new target pathway for MMP-9 action in key physiological and pathological brain processes.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.303
Twórcy
autor
  • Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Laboratory of Cellular Physiology of the Synapse, University of Bordeaux 2, Bordeaux, France
autor
  • Laboratory of Cellular Physiology of the Synapse, University of Bordeaux 2, Bordeaux, France
  • Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany
autor
  • Laboratory of Cellular Physiology of the Synapse, University of Bordeaux 2, Bordeaux, France
autor
  • Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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