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2013 | 72 | 3 |

Tytuł artykułu

Ossification of the vertebral column in human foetuses: histological and computed tomography studies

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
There is no agreement in the literature as to the time of the onset and progress of the vertebral column ossification. The aim of the present study was to determine the precise sequence of ossification of the neural arches and vertebral centra. Histological and radiographic studies were performed on 27 human foetuses aged from 9 to 21 weeks. It was found that the ossification of vertebrae commences in foetuses aged 10 and 11 weeks. Ossification centres appear first for neural arches in the cervical and upper thoracic vertebrae and by the end of 11th week they are present in all thoracic and lumbar neural arches. In the vertebral centra in foetus of 10 weeks ossification was found in the lower 7 thoracic and first lumbar vertebrae. By the end of 11th week ossification is present in the lower 4 cervical, all thoracic, all lumbar and 4 sacral vertebral centra. The study indicates that ossification of the neural arches proceeds in the craniocaudal direction, whereas in the vertebral centra it progresses from the lower thoracic vertebrae into both directions. Different shapes of ossification centres were also described. (Folia Morphol 2013; 72, 3: 230–238)

Wydawca

-

Czasopismo

Rocznik

Tom

72

Numer

3

Opis fizyczny

p.230-238,fig.,ref.

Twórcy

  • Department of Anatomy, Poznan University of Medical Sciences, Swięcickiego 6, 60-781 Poznan, Poland
  • Department of Anatomy, Poznan University of Medical Sciences, Swięcickiego 6, 60-781 Poznan, Poland
autor
  • Department of Anatomy, Poznan University of Medical Sciences, Swięcickiego 6, 60-781 Poznan, Poland
autor
  • Department of Anatomy, Poznan University of Medical Sciences, Swięcickiego 6, 60-781 Poznan, Poland
autor
  • Department of Anatomy, Poznan University of Medical Sciences, Swięcickiego 6, 60-781 Poznan, Poland
  • Medical Faculty, Higher Vocational State School, Kalisz, Poland

Bibliografia

  • 1. Balling R, Helwig U, Nadeau J, Neubuser A, Schmahl W, Imai K (1996) Pax genes, and skeletal development. Ann NY Acad Sci, 785: 27–33.
  • 2. Bagnall KM, Harris PF, Jones PRM (1977) A radiographic study of the human fetal spine. 1. The development of the secondary cervical curvature. J Anat, 123: 777–782.
  • 3. Bagnall KM, Harris PF, Jones PRM (1977) A radiographic study of the human fetal spine. 2. The sequence of development of ossification centres in the vertebral column. J Anat, 124: 791–602.
  • 4. Bagnall KM, Harris PF, Jones PRM (1982) A radiographic study of the growth in width of the human fetal vertebral column. Anat Rec, 204: 265–262
  • 5. Barregi R, Grill V, Zweyer M, Narducci P, Forabosco A (1994) A quantitative study on the special and temporal ossification patterns of vertebral centra and neural arches and their relationship to the fetal age. Ann Anat, 176: 311–317.
  • 6. Budorick NE, Pretorius DH, Garfe MR, Lou KV (1991) Ossification of the fetal spine. Radiology, 181: 561–565.
  • 7. Cortina H, Vidal J, Vallancera A, Alberto C, Muro D, Dominiguez F (1979) Humero-spinal dysostosis. Pediat Radiol, 8: 188–190.
  • 8. Currarino G (1986) Unusual bone dysplasia featuring severe platyspondyly and vertebral “coronal cleft” in infancy, and changes of metaphyseal chondrodysplasia in childchood. Pediat Radiol, 16: 433–436.
  • 9. Dietrich S, Schubert FR, Lumsden A (1997) Control of dorsoventral pattern in the chick paraxial mesoderm. Development, 124: 3895–3908.
  • 10. Faivre L, Cormier-Daire V, Eliott AM, Field F, Munnich A, Martoeaux P, Le Merrer M, Lachman R (2004) Desbuquois dysplasia, a reevaluation with abnormal and “normal” hands: radiographic manifestations. Am J Med Genet, 124: 48–53.
  • 11. Goldstein RS, Kalcheim C (1992) Determination of epithelial half-somites in skeletal morphogenesis. Development, 116: 441–445.
  • 12. Gilbert EF, Opitz JM, Spranger JW, Langer LO, Wolfson JJ, Viseskul C (1976) Chondrodysplasia punctate: rhizomelic form. Pathologic and radiologic studies of three infants. Eur J Pediat, 123: 89–109.
  • 13. Handmaker SD, Campbell JA, Robinson LD, Chinwah O, Gorlin RJ (1977) Dyssegmental dwarfizm: a new syndrome of lethal dwarfism. Birth Defects, 13: 79–90.
  • 14. Harten van der HJ, Brons JT, Schipper NW, Dijkstra PF, Meijer CJ, van Geijn HP (1990) The prenatal development of the normal human skeleton: a combined ultrasonographic and post-mortem radiographic study. Pediat Radiol, 21: 52–56.
  • 15. Kieny M, Meuger A, Sengel P (1972) Early regionalization of the somatic mesoderm as studied by the development of the axial skeleton of the chick embryo. Dev Biol, 28: 142–161.
  • 16. Kjaer I, Kjaer TW, Gravem N (1998) Ossification sequence of occipital bone and vertebrae in human fetuses. J Craniofac Genet Dev Biol, 13: 83–88.
  • 17. Kosa F, Castellana C (2005) New forensic anthropological approachment for the age determination of human fetal skeletons on the base of morphometry of vertebral column. Foren Sci Int 147: 69–74.
  • 18. Kuwashima S, Nishimura G, Kikushima H, Tanaka G, Furukawa T, Fujioka M (1992) Atelosteogenesis type 3: the first patient in Japan and survivor for more than 1 year. Acta Paediat Jpn, 34: 543–546.
  • 19. Langer LO, Gonzales-Ramos M, Chen H, Espritu CE, Courtney NW, Opitz JM (1976) A severe infantile micromelic chondrodysplasia which resembles Kniest disease. Eur J Pediat, 123: 29–38.
  • 20. Larsen WJ (2001) Human embryology. 3rd Ed. Churchill Livingstone, New York, Edinburgh, London, Philadelphia.
  • 21. Lopez BC, David KM, Crockard HA (1997) Inadequate Pax-1 gene expression as a cause of agenesis of the thoracolumbar spine with failure of segmentation. J Neurosurg, 86: 1018–1021.
  • 22. Ming JE, McDonald-McGinn DM, Megerian TE, Driscoll DA, Elias ER, Russell BM, Irons M, Emanuel BS, Markowitz RI, Zackai EH (1997) Skeletal anomalies and deformities in patients with deletions of 22q11. Am J Med Genet, 72: 210–215.
  • 23. Monish Suri, Garret C, Winter RM, Hall CM, Griffiths M (2002) Dysplastic cortical hyperostosis (Kozlowski-Tsuruta syndrome): report of the second case. Clin Dysmorphol, 11: 267–270.
  • 24. Monsoro-Burgh AH, Duprez D, Watanabe Y, Bontoux M (1996) The role of bone morphogenetic proteins in vertebral development. Development, 122: 3007–3014.
  • 25. Noback CR, Robertson GG (1951) Sequences of appearance of ossification centers in the human skeleton during the first five prenatal months. Am J Anat, 89: 1–28.
  • 26. Nolting D, Hansen BF, Kesling JK, Kjaer I (1998) Prenatal development of the normal human vertebral corpora in different segments of the spine. Spine, 23: 2265–2271.
  • 27. O’Rahilly R, Benson DR (1985) The development of the vertebral column. In: Bradford DS, Hensinger RM eds. The pediatric spine. Thieme, New York, pp. 3–17.
  • 28. O’Rahilly R, Meyer DB (1956) Roentgenographic investigation of the human skeleton during early fetal life. Am J Roentgenol Radium Ther Nucl Med, 76: 455–468.
  • 29. O’Rahilly R, Meyer DB (1979) The timing and sequence of events in the development of the human vertebral column during the embryonic period proper. Anat Embryol, 157: 167–176.
  • 30. O’Rahilly R, Müller F (2001) Human embryology and teratology. 3rd Ed. John Willey and Sons, Inc. Publ. New York, Chichester, Wienheim, Brisbane, Singapore, Toronto.
  • 31. O’Rahilly R. Müller F. (2003) Somites, spinal ganglia, and centra. Cells Tiss Org, 174: 75–92.
  • 32. Reichmann S, Lewin T (1969) Coronal cleft vertebrae in growing individuals. A preliminary report. Acta Orthop Scandinav, 40: 3–22.
  • 33. Riggio S, Burroni M, Merli A (1976) Frontal vertebral cleft in the newborn. Minerva Med, 67: 1413–1416.
  • 34. Sensenig EC (1951) The early development of the meninges of the spinal cord on human embryos. Contr Embryol Carneg Instn, 34: 145–157.
  • 35. Sensenig EC (1957) The development of the occipital and cervical segments and their associated structures in human embryos. Contr Embryol Carneg Instn, 36: 141–152.
  • 36. Smith CA, Tuan RS (1994) Human PAX gene expression and development of the vertebral column. Clin Orthop, 302: 241–250.
  • 37. Tanaka T, Unthoff HK (1983) Coronal cleft of vertebrae, a variant of normal enchondral ossification. Acta Orthop Scand, 54: 389–395.
  • 38. Tondury G (1958) Entwicklungsgeschichte und Fehlbildungen der Würbelsäule. Hippokrates, Stuttgart 1952.
  • 39. Verbout AJ (1985) The development of the vertebral column. Adv Anat Embryol Cell Biol, 90: 1–122.
  • 40. Weisenbach J, Melegh B (1996) Vertebral anomalies in Larsen’s Syndrome. Pediat Radiol, 26: 682–683.
  • 41. Wells TR, Landing BH, Bostwick FH (1992) Studies of vertebral coronal cleft in rhizomelic chondrodysplasia punctata. Pediat Pathol, 12: 593–600.
  • 42. Westvik J, Lechman R (1998) Coronal and sagittal clefts in skeletal dysplasias. Pediat Radiol, 28: 764–770.

Typ dokumentu

Bibliografia

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