Polyphenol-rich diet is associated with decreased level of inflammatory biomarkers in breast cancer patients

• Autorzy: Sut A. , Pytel M. , Zadrozny M. , Golanski J. , Rozalski M.
• Języki publikacji: EN

Abstrakty

EN

Background. The study investigated the relationship between dietary intake of polyphenols and inflammatory markers: CRP, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), medium platelet volume/lymphocyte ratio (MPVRL), in newly-diagnosed breast cancer patients. Objectives. The aim of this work was to verify whether diet rich in plant polyphenols affects inflammatory markers in breast cancer patients. Materials and methods. 78 patients (55.3±14.5 years) treated surgically for breast cancer were studied. A modified FFQ and authorial worksheet based on the Phenol Explorer database was used to measure the amount of plant polyphenols in a diet. Basing on the median of polyphenols intake (1780 mg/day), the group was divided into two subgroups: low- and high- dietary intake of polyphenols (LDIP and HDIP, respectively). Plasma CRP level was measured and NLR, PLR and MPVLR were calculated using results from peripheral blood morphology. Results. LDIP was associated with significantly higher CRP (elevated in 34.5% LDIP patients vs. 8.3% HDIP, p<0.003), NLR (elevated in 46.2% LDIP patients vs. 25.6% HDIP, p<0.006) and PLR level (elevated in 25.6% LDIP patients vs. 12.8% HDIP, p<0.03). MPVLR was not significantly different between both the subgroups. Conclusion. High dietary intake of polyphenols remarkably reduced process of inflammation in breast cancer patients, which has important clinical implications. The study demonstrated also an usefulness of simple, cheap and commonly available biomarkers for monitoring anti-inflammatory effects of diet.

PL

Wprowadzenie. Badano zależność pomiędzy pobraniem polifenoli wraz z dietą a poziomem markerów stanu zapalnego: CRP, wskaźnika neutrofile/limfocyty (NLR), płytki/limfocyty (PLR) oraz średnia objętość płytek/limfocyty (MPVLR) wśród nowo zdiagnozowanych pacjentek z rakiem piersi. Cel. Celem pracy było zweryfikowanie czy dieta bogata w polifenole roślinne wpływa na parametry stanu zapalnego u pacjentek z rakiem piersi. Materiały i metody. Do badania włączono 78 pacjentek (55.3±14.5 lat) klasyfikowanych do leczenia chirurgicznego raka piersi. Do oszacowania zawartości polifenoli w diecie użyto zmodyfikowanego zwalidowanego FFQ i autorskiego arkusza opartego na bazie Phenol Explorer. Po wyliczeniu median spożycia polifenoli (1780mg/dobę), podzielono pacjentki na dwie grupy: niskiego i wysokiego spożycia polifenoli (odpowiednio LDIP I HDIP). Zmierzono stężenie CRP oraz na podstawie wyników morfologii krwi obwodowej wyliczono wskaźniki NLR, PLR oraz MPVLR. Wyniki. W grupie z niższym pobraniem polifenoli zaobserwowano znacząco wyższe wartości CRP (podwyższone u 34.5% vs grupa wysokiego spożycia 8.3%, p<0.003), NLR (podwyższone w 46.2% vs 25.6%, p<0.006) oraz poziom PLR (podwyższone u 25.6% vs 12.8%, p<0.03). Wartości MPVLR nie różniły się istotnie pomiędzy podgrupami. Wnioski. Wysokie spożycie polifenoli znacząco redukowało proces zapalny u pacjentek z rakiem piersi, co ma znaczące implikacje kliniczne. Badanie przedstawiło również użyteczność prostych, tanich i powszechnie dostępnych biomarkerów do monitorowania przeciwzapalnego wpływu diety.

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2019
• Tom: 70
• Numer: 2
• Opis fizyczny: p.177-184,fig.,ref.

Twórcy

autor

Sut A.

• Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Lodz, Poland

autor

Pytel M.

• Therapeutic and Diagnostic Oncological Centre Nu-Med., Tomaszow Mazowiecki, Poland

autor

Zadrozny M.

• Department of Oncological Surgery and Breast Diseases, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland

autor

Golanski J.

• Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Lodz, Poland

autor

Rozalski M.

• Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Lodz, Poland

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Identyfikatory

DOI

10.32394/rpzh.2019.0068