PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2009 | 69 | 3 |
Tytuł artykułu

Adenosine receptor agonists attenuate the expression of sensitization to morphine induced place preference in rats

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Behavioural sensitization is an enhancement of certain drug-induced effects which develops following repeated, intermittent exposure to opioids and psychoactive drugs. The sensitization can be measured in various animal models, e.g. conditioned place preference paradigm. In the present studies we undertook to investigate an involvement of adenosine receptor agonists in expression of sensitization to morphine-induced rewarding effects in rats. Three, intraperitoneal (i.p.) injections of morphine (5.0 mg/kg) induced conditioned place preference. Five days later, in animals with prior history of morphine administration, ineffective dose of morphine (0.75 mg/kg i.p.) was administered. That dose was able to induce a signifi cant intensifi cation of morphine response in conditioned place preference paradigm. It showed that morphine-induced sensitization to rewarding effects had been developed. To determine the effects of adenosine receptor agonists on expression of sensitization, selective and non-selective drugs were administered 15 min before the last injection of morphine. We showed that all adenosine drugs were able to attenuate the expression of morphine sensitization and the strongest effects were produced by selective (A1) and non-selective (A1 and A2A) adenosine receptor agonists. We conclude that adenosine agonists may play an important role in drugseeking behaviour underlying the development of addiction.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.349
Twórcy
autor
  • Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
autor
  • Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
autor
  • Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-244cb61d-9785-4817-a194-489d321d6209
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.