Bone mineral density (BMD) and computer tomographic measurements of the equine proximal phalanx in correlation with breaking strength

• Autorzy: Toth P. , Horvath C. , Ferencz V. , Toth B. , Varadi A. , Szenci O. , Bodo G.
• Języki publikacji: EN

Abstrakty

EN

Despite the fact that bone mineral density (BMD) is an important fracture risk predictor in human medicine, studies in equine orthopedic research are still lacking. We hypothesized that BMD correlates with bone failure and fatigue fractures of this bone. Thus, the objectives of this study were to measure the structural and mechanical properties of the proximal phalanx with dual energy X-ray absorptiometry (DXA), to correlate the data obtained from DXA and computer tomography (CT) measurements to those obtained by loading pressure examination and to establish representative region of interest (ROI) for in vitro BMD measurements of the equine proximal phalanx for predicting bone failure force. DXA was used to measure the whole bone BMD and additional three ROI sites in 14 equine proximal phalanges. Following evaluation of the bone density, whole bone, cortical width and area in the mid-diaphyseal plane were measured on CT images. Bones were broken using a manually controlled universal bone crusher to measure bone failure force and reevaluated for the site of fractures on follow-up CT images. Compressive load was applied at a constant displacement rate of 2 mm/min until failure, defined as the first clear drop in the load measurement. The lowest BMD was measured at the trabecular region (mean ± SD: 1.52 ± 0.12 g/cm2; median: 1.48 g/cm2; range: 1.38-1.83 g/cm2). There was a significant positive linear correlation between trabelcular BMD and the breaking strength (P=0.023, r=0.62). The trabecular region of the proximal phalanx appears to be the only significant indicator of failure of strength in vitro. This finding should be reassessed to further reveal the prognostic value of trabecular BMD in an in vivo fracture risk model.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2013
• Tom: 16
• Numer: 1
• Opis fizyczny: p.3-8,fig.,ref.

Twórcy

autor

Toth P.

• Faculty of Veterinary Science, Clinic for Large Animals, Szent Istvan University, 2225 Ullo, Dora major, Hungary

autor

Horvath C.

• First Department of Medicine, Semmelweis University of Medicine, Budapest, Hungary

autor

Ferencz V.

• First Department of Medicine, Semmelweis University of Medicine, Budapest, Hungary

autor

Toth B.

• Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA

autor

Varadi A.

• Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary

autor

Szenci O.

• Faculty of Veterinary Science, Clinic for Large Animals, Szent Istvan University, 2225 Ullo, Dora major, Hungary

autor

Bodo G.

• Department of Clinical Veterinary Science, Equine Clinic, University of Bern, Switzerland

Bibliografia

• Baxter GM, Turner AS (2002) Diseases of bone and related structures. In: Stashak TS (ed) Adam’s lameness in horses. 5th ed., Philadelphia, Lippincott Williams and Wilkins, pp 401-457.
• Beaupied H, Dupuis A, Arlettaz A, Brunet-Imbault B, Bonnet N, Jaffre´ C, Benhamou CL, Courteix D (2006) The mode of conservation does not affect the architecture and the tensile properties of rat femurs. Biomed Mater Eng 16: 253-259.
• Bynum D Jr, Ledbetter WB, Boyd CL, Ray DR (1971) Flexural properties of equine metacarpus. J Biomed Mater Res 5: 63-79.
• Carter DR, Hayes WC (1977) The compressive behavior of bone as a two-phase porous structure. J Bone Joint Surg Am 59: 954-962.
• Davies HM (2009) Ex vivo calibration and validation of in vivo equine bone strain measures. Equine Vet J 41: 225-228.
• Dzierzęcka M, Charuta A (2012) Bone minearl density and bone mineral content of the bilateral first phalanges of the thoracic limbs in horses. Pol J Vet Sci 15: 159-161.
• El Shorafa WM, Feaster JP, Ott EA (1979) Horse metacarpal bone: age, ash content, cortical area and failure stress interrelationships. J Anim Sci 49: 979- 982.
• Ellis DR, Simpson DJ, Greenwood RE, Crowhurst JS (1987) Observations and management of fractures of the proximal phalanx on young thoroughbreds. Equine Vet J 19: 43-49.
• Genant HK, Grampp S, Gluer CC, Faulkner KG, Jergas M, Engelke K, Hagiwara S, Van Kuijk C (1994) Universalstandardization for dual x-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res9: 1503-1514.
• Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Harris ST, Jergas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M (1996) Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 11: 707-730.
• Goodship AE, Smith RK (2004) Skeletal physiology: Responsive to exercise and training. In: Hinchcliff KW, Kaneps AJ, Geor RJ (eds) Equine sports medicine and surgery. 1st ed., Philadelphia, Saunders, pp 111-129.
• Grier SJ, Turner AS, Alvis MR (1996) The use of dual-energy x-ray absorptiometry in animals. Invest Radiol 31: 50-62.
• Griffin MG, Kimble R, Hopfer W, Pacifici R (1993) Dual-energy x-ray absorptiometry of the rat: accuracy, precision, and measurement of bone loss. J Bone Miner Res 8: 795-800.
• Ijiri K, Jee WS, Ma YF, Yuan Z (1995) Remobilization partially restored the bone mass in the non-growing cancellous bone site following long term immobilization. Bone 17: 213S-217S.
• Johnson BJ, Ardans AA, Daft BM (1994) California racehorse postmortem programme: a 4-year overview. Proc Am Ass Equi Pract 40: 167-169.
• Kazarian LE, von Gierke HE (1965) Bone loss as a result of immobilization and chelation. Preliminary results in Macaca mulatta. Clin Orthop 65: 67-75.
• Lawrence LA (2005) Effects of exercise and training on skeletal development in horses. In: Pagan JD (ed) Advances in equine nutrition. 3rd ed., Nottingham, Nottingham University Press, pp 219-226.
• Nixon AJ (2012) Phalanges and the metacarpophalangeal and metatarsophalangeal joints. In: Auer JA, Stick JA (eds) Equine surgery. 4th ed., St. Louis, Saunders Elsevier, pp 1300-1325.
• Nunamaker DM, Butterweck DM, Provost MT (1989) Some geometric properties of the third metacarpal bone: a comparison between the thoroughbred and standardbred racehorse. J Biomech 22: 129-134.
• Nunamaker DM, Butterweck DM, Provost MT (1990) Fatigue fractures in thoroughbred racehorses: relationships with age, peak bone strain, and training. J Orthop Res 8: 604-611.
• Riggs CM (2002) Fractures-a preventable hazard of racing thoroughbreds? Vet J 163: 19-29.
• Rooney JR (1969) Biomechanics of lameness in horses. Baltimore, Williams and Wilkins, pp 164-167.
• Rozenberg S, Vandromme J, Neve J, Aguilera A, Muregancuro A, Peretz A, Kinthaert J, Ham H (1995) Precision and accuracy of in vivo bone mineral measurement in rats using dual-energy x-ray absorptiometry. Osteoporos Int 5: 47-53.
• Ruggles AJ (2003) The proximal and middle phalanges and proximal interphalangeal joint. In: Dyson SJ, Ross MW (eds) Diagnosis ans management of lameness in the horse. 1st ed., St. Louis, Elsevier, pp 343-344.
• Sherman KM, Miller GJ, Wronski TJ, Colahan PT, Brown M, Wilson W (1995) The effect of training on equine etacarpal bone breaking strength. Equine Vet J 27: 135-139.
• Smith H (2010) Comparison of fracture incidence, type and the associated pain between working equids in Egypt and horses in a UK based referral hospital. Taws Overseas Travel Grant Project Report, pp. 1-17.
• Stashak TS (2002) Fractures of the proximal phalanx. In: Stashak TS (ed) Adam’s lameness in horses. 5th ed., Philadelphia, Lippincott Williams and Wilkins, pp 755-764.
• Thompson KN, Cheung TK, Putnam M (1996) Computerized bone density analysis of the proximal phalanx of the horse. Equi Pract 18: 26-29.
• Tóth P, Horva´th C, Ferencz V, Nagy K, Gligor N, Szenci O, Bodó G (2010) Assessment of the mineral density and mineral content of the equine third metacarpal and first phalanx bone by dual energy x-ray absorptiometry. Acta Vet Hung 58: 317-329.
• Turner AS, Mallinckrodt CH, Alvis MR, Bryant HU (1995) Dual-energy X-ray absorptiometry in sheep: experiences with in vivo and ex vivo studies. Bone 17: 381S-387S.
• Vaughan LC, Mason BJE (1976) A clinico-pathological study of racing accidents in horses. A report of a study on equine fatal accidents on racecourses. Horserace Betting Levy Board, London, United Kingdom, pp 3-88.
• Young DR, Nunamaker DM, Markel MD (1991) Quantitative evaluation of the remodeling response of the proximal sesamoid bones training-related stimuli in thoroughbreds. Am J Vet Res 52: 1350-1356.

Uwagi

PL

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