Longitudinal intra-homecage phenotyping of a transgenic rat model of Alzheimer’s disease

• Autorzy: Canneva F.
• Języki publikacji: EN

Abstrakty

EN

A comprehensive behavioral screening was carried out in the McGill-R-Thy1-APP rat model of Alzheimer’s disease, over 11 months. Classical behavioral read-outs were performed parallel to intra-homecage metabolic measurements (PhenoMaster®) and operant conditioning (IntelliMaze®), once every 3 months. The collection of data gathered in this study offers a measure of the sensitivity and throughput of automated phenotyping as compared to classical paradigms, for the detection of cognitive and noncognitive alterations in transgenic rats

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.351

Twórcy

autor

Canneva F.

• Experimental Therapy, Preclinical Experimental Center, University of Erlangen, Erlangen, Germany