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2015 | 18 | 4 |
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Is downer cow syndrome related to chronic botulism?

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The present work was directed to investigate the relationship between Downer cow syndrome (DCS) and chronic botulism in dairy cattle. For this purpose, a total of 52 fresh calving downer cows and 206 apparently healthy cows at 14 dairy farms were investigated for Clostridium botulinum ABE and CD antibody levels, C. botulinum and botulinum neurotoxin in rumen fluids as well as in faeces. Results indicated that the downer cows had higher IgG titers for C. botulinum ABE and CD than the healthy cows. All tested rumen fluids were negative for BoNT and C. botulinum. BoNT/D, however, and C. botulinum type D spores were detected in faecal samples of healthy and downer cows in the selected farms. In conclusion, the presence of a significantly higher C. botulinum ABE and CD antibody levels in DCS cows than in the healthy animals suggests that chronic C. botulinum toxico-infection could be a predisposing factor for DCS.
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  • State Office of Consumer Protection, Sachsen - Anhalt, Special field 4 – Veterinary Sector, Haferbreiter Weg 132-135, 39576 Stendal, Germany
  • Institute of Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany
  • Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Qalioubeya, Egypt
  • Institute of Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany
  • Institute of Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany
  • Bagge E, Persson M, Johansson KE (2010) Diversity of spore-forming bacteria in cattle manure, slaughterhouse waste and samples from biogas plants. J Appl Microbiol 109: 1549-1565.
  • Barash JR, Arnon SS (2014) A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins. J Infect Dis 209: 183-191.
  • Barlet JP, Davicco MJ (1992) 1 alpha-hydroxycholecalciferol for the treatment of the downer cow syndrome. J Dairy Sci 75: 1253-1256.
  • Barry GF, Kishore GM, Padgette SR, Stallings WC (1992) Glyphosate tolerant 5-enolpyruvylshikimate-3-phosphate synthases. World Patent, US5633435 A.
  • Bohnel H, Lube K (2001) Clostridium botulinum and bio-compost. A contribution to the analysis of potential health hazards caused by bio-waste recycling. J Vet Med B Infect Dis Vet Public Health 47: 785-795.
  • Böhnel H, Schwagerick B, Gessler F (2001) Visceral botulism – a new form of bovine Clostridium botulinum toxication. J Vet Med A Physiol Pathol Clin Med 48: 373-383.
  • Brown AT, Gregory AR, Ellis TM, Hearnden MN (1999) Comparative immunogenicity of two bivalent botulinum vaccines. Aust Vet J 77: 388-391.
  • Dover N, Barash JR, Hill KK, Xie G, Arnon SS (2014) Molecular characterization of a novel botulinum neurotoxin type H gene. J Infect Dis 209: 192-202.
  • Eddy RG (2004) Major Metabolic Disorders. In: Andrews AH, Blowey RW, Boyd H, Eddy RG (Eds) Bovine medicine. Diseases and husbandry of cattle. 2 nd., Oxford: Blackwell Sci Publ, pp 781-803.
  • Foran PG, Mohammed N, Lisk GO, Nagwaney S, Lawrence GW, Johnson E, Smith L, Aoki KR, Dolly JO (2003) Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons. J Biol Chem 278: 1363-1371.
  • Fujinaga Y, Inoue K, Watanabe S, Yokota K, Hirai Y, Nagamachi E, Oguma K (1997) The haemagglutinin of Clostridium botulinum type C progenitor toxin plays an essential role in binding of toxin to the epithelial cells of guinea pig small intestine, leading to the efficient absorption of the toxin. Microbiology 143: 3841-4847.
  • Fujinaga Y, Matsumura T, Jin Y, Takegahara Y , Sugawara Y (2009) A novel function of botulinum toxin-associated proteins: HA proteins disrupt intestinal epithelial barrier to increase toxin absorption. Toxicon 54: 583-586.
  • Fujinaga Y (2010) Interaction of botulinum toxin with the epithelial barrier. J Biomed Biotechnol 2010:974943. doi: 10.1155/2010/974943.
  • Fürll M (2005) Gebärparese, Hypophosphatämisches Festliegen, Downer cow syndrome. In: Hofman, W. (Hrsg.): Rinderkrankheiten – Innere und chirurgische Erkrankungen, 2. Aufl. Stuttgart, Eugen Ulmer Verlag: 407-415.
  • Goff JP (2004) Macromineral disorders of the transition cow. Vet Clin North Am Food Anim Pract 20: 471-494.
  • Holzhauer M, Roest HI, de Jong MG, Vos JH (2009) Botulism in dairy cattle in 2008: symptoms, diagnosis, pathogenesis, therapy, and prevention. Tijdschr Diergeneeskd 134: 564-570.
  • Inui K, Ito H, Miyata K, Matsuo T, Horiuchi R, Ikeda T, Watanabe T, Ohyama T, Niwa K (2010) Involvement of sialic acid in transport of serotype C1 botulinum toxins through rat intestinal epithelial cells. J Vet Med Sci 72: 1251-1255.
  • Keller JE (2006) Recovery from botulinum neurotoxin poisoning in vivo. Neuroscience 139: 629-637.
  • Krüger M, Große-Herrenthey A, Schrodl W, Gerlach A, Rodloff A (2012) Visceral botulism at dairy farms in Schleswig Holstein, Germany: prevalence of Clostridium botulinum in feces of cows, in animal feeds, in feces of the farmers, and in house dust. Anaerobe 18: 221-223.
  • Krüger A, Skau M, Shehata AA, Schrödl W (2013) Efficacy of Clostridium botulinum types C and D toxoid vaccination in Danish cows. Anaerobe 23: 97-101.
  • Krüger M, Shehata AA, Grosse-Herrenthey A, Ständer N, Schrödl W (2014) Relationship between gastrointestinal dysbiosis and Clostridium botulinum in dairy cows. Anaerobe 27: 100-105.
  • Lindsey CY, Smith LA, West MW, Boles LW, Brown JE (2003) Evaluation of a botulinum fragment C-based ELISA for measuring the humoral immune response in primates. Biologicals 31: 17-24.
  • Long SC, Tauscher T (2006) Watershed issues associated with Clostridium botulinum: a literature review. J Water Health 4: 277-88.
  • Lund BM, Peck MW (2001) Clostridium botulinum. In: Lund BM, Baird-Parker AC, Gould GW (eds). The microbiological safety and quality of food. Gaithersburg: Aspen, pp 1057-1109.
  • Nakamura T, Takada N, Tonozuka T, Sakano Y, Oguma K, Nishikawa A (2007) Binding properties of Clostridium botulinum type C progenitor toxin to mucins. Biochim Biophys Acta 1770: 551-555.
  • Neuhaus J, Schrödl W, Shehata AA, Krüger M (2015) Detection of Clostridium botulinum in liquid manure and biogas plant wastes. Folia Microbiol (Praha) 60: 451-6.
  • Pehrson B (2002) Studien uber das Festliegen („Downer-Syndrome”) bei Milchkuhen. In: Gropp J, Ribbeck R (Hrsg.). Atypisches Festliegen beim Rind. Kongressband Internationaler Workshop. 2. Leipziger Tierarztekongress. ISBN: 3-00-008948-9; 308.
  • Popoff MR (2014) Botulinum neurotoxins: more and more diverse and fascinating toxic proteins. J Infect Dis 209: 168-169.
  • Relman DA (2014) „Inconvenient truths” in the pursuit of scientific knowledge and public health. J Infect Dis 209: 170-172.
  • Sagane Y, Inui K, Miyashita SI, Miyata K, Niwa K, Watanabe T, Suzuki T (2012) Botulinum toxin complex: a delivery vehicle of botulinum neurotoxin traveling in the digestive tract. In: Ayman Ameu Eisse (Ed.) Structure and Function of Food Engineering. InTech, Rijeka, pp 137-150.
  • Shehata AA, Schrodl W, Aldin AA, Hafez HM, Kruger M (2013) The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr Microbiol 66: 350-58.
  • Steinman A, Galon N, Arazi A, Bar-Giora Y, Shpigel NY (2007) Cattle immune response to botulinum type D toxoid: results of a vaccination study. Vaccine 25: 7636-7640.
  • Williamson JL, Rocke TE, Aiken JM (1999) In situ detection of the Clostridium botulinum type C1 toxin gene in wetland sediments with a nested PCR assay. Appl Environ Microbiol 65: 3240-3243.
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