PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2009 | 69 | 3 |
Tytuł artykułu

HIV-1 and amyloid beta peptide interactions at the blood-brain barrier level

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
An increase in the older population infected with HIV-1 is an emerging development in HIV-1 epidemiology. Aging is connected with increased deposition of amyloid beta peptide (amyloid beta) in the brain. In the current study, we propose that amyloid beta and HIV-1 can potentiate their toxic effects at the blood–brain barrier (BBB) level. To address this notion, we employed an in vitro model of human brain microvascular endothelial cells (HBMEC) directly exposed to HIV-1 or co-cultured with HIV-1 infected human monocytes. Exposure of HBMEC to amyloid beta (1-40) in the presence of HIV-1 resulted in a markedly increased amyloid beta binding/entry into HBMEC. We then hypothesized that HIV-1 may either increase binding/entry of externally added amyloid beta or elevate the amount of endogenously produced amyloid beta. The receptor for advanced glycation end products (RAGE) is known to be involved in the transport of amyloid beta across the BBB into the brain. RAGE immunoreactivity was stronger and RAGE protein levels were elevated in HBMEC exposed to HIV-1 as compared to control. In contrast, exposure to HIV-1 decreased expression of lipoprotein receptor related protein-1 (LRP1) which is the main receptor that transports amyloid beta from the brain to blood. These results indicate that HIV-1 can decrease the ability of the BBB to transport amyloid beta from the brain and thus predispose the brain to increased amyloid beta accumulation. Supported by MH072567, MH63022, and NS39254
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.285-286
Twórcy
autor
  • Molecular Neuroscience and Viscular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, KY, USA
autor
  • Molecular Neuroscience and Viscular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, KY, USA
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-1bbcdee2-761a-4c49-9ae0-90b4cbfc0e72
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.