Tendon — function-related structure, simple healing process and mysterious ageing

• Autorzy: Zabrzynski J. , Lapaj L. , Paczesny L. , Zabrzynska A. , Grzanka D.
• Języki publikacji: EN

Abstrakty

EN

Tendons are connective tissue structures of paramount importance to human ability of locomotion. The understanding of their physiology and pathology is gaining importance as advances in regenerative medicine are being made today. So far, very few studies were conducted to extend the knowledge about pathology, healing response and management of tendon lesions. In this paper we summarise actual knowledge on structure, process of healing and ageing of the tendons. The structure of tendon is optimised for the best performance of the tissue. Despite the simplicity of the healing response, numerous studies showed that the problems with full recovery are common and much more significant than we thought; that is why we discussed the issue of immobilisation and mechanical stimulation during healing process. The phenomenon of tendons’ ageing is poorly understood. Although it seems to be a natural and painless process, it is completely different from degeneration in tendinopathy. Recent studies of biological treatment reported faster and optimal healing of the tendons when augmented by growth factors and stem cells. Despite advances in biology of tendons, management of their injuries is still a challenge for physicians; therefore, further studies are required to improve treatment outcomes. (Folia Morphol 2018; 77, 3: 416–427)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2018
• Tom: 77
• Numer: 3
• Opis fizyczny: p.416–427,fig.,ref.

Twórcy

autor

Zabrzynski J.

• Multidisciplinary Hospital, Department of Orthopaedic Surgery, Poznanska 97, 88–100 Inowroclaw, Poland

autor

Lapaj L.

• Department of General, Oncologic Orthopaedics and Traumatology, Karol Marcinkowski Medical University, Poznan, Poland

autor

Paczesny L.

• Department of Orthopaedic Surgery, Orvit Clinic, Torun, Poland

autor

Zabrzynska A.

• Division of Radiology, Dr Blazek’s District Hospital, Inowroclaw, Poland

autor

Grzanka D.

• Department of Clinical Pathomorphology, University Hospital No. 1, Bydgoszcz, Poland

Bibliografia

• 1. Abate M, Silbernagel KG, Siljeholm C, et al. Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Res Ther. 2009; 11(3): 235, doi: 10.1186/ar2723, indexed in Pubmed: 19591655.
• 2. Adams CW, Bayliss OB. Acid mucosubstances underlying lipid deposits in ageing tendons and atherosclerotic arteries. Atherosclerosis. 1973; 18(2): 191–195, indexed in Pubmed: 4355127.
• 3. Akizuki KH, Gartman EJ, Nisonson B, et al. The relative stress on the Achilles tendon during ambulation in an ankle immobiliser: implications for rehabilitation after Achilles tendon repair. Br J Sports Med. 2001; 35(5): 329–33; discussion 333, indexed in Pubmed: 11579067.
• 4. Andarawis-Puri N, Flatow EL, Soslowsky LJ. Tendon basic science: Development, repair, regeneration, and healing. J Orthop Res. 2015; 33(6): 780–784, doi: 10.1002/jor.22869, indexed in Pubmed: 25764524.
• 5. Aspenberg P. Stimulation of tendon repair: mechanical loading, GDFs and platelets. A mini-review. Int Orthop. 2007; 31(6): 783–789, doi: 10.1007/s00264-007-0398-6, indexed in Pubmed: 17583812.
• 6. Awad HA, Butler DL, Boivin GP, et al. Autologous mesenchymal stem cell-mediated repair of tendon. Tissue Eng. 1999; 5(3): 267–277, doi: 10.1089/ten.1999.5.267, indexed in Pubmed: 10434073.
• 7. Benjamin M, Toumi H, Ralphs JR, et al. Where tendons and ligaments meet bone: attachment sites (‘entheses’) in relation to exercise and/or mechanical load. J Anat. 2006; 208(4): 471–490, doi: 10.1111/j.1469-7580.2006.00540.x, indexed in Pubmed: 16637873.
• 8. Birk DE, Mayne R. Localization of collagen types I, III and V during tendon development. Changes in collagen types I and III are correlated with changes in fibril diameter. Eur J Cell Biol. 1997; 72(4): 352–361, indexed in Pubmed: 9127735.
• 9. Chaudhury S. Mesenchymal stem cell applications to tendon healing. Muscles Ligaments Tendons J. 2012; 2(3): 222–229, indexed in Pubmed: 23738300.
• 10. Clarke AW, Alyas F, Morris T, et al. Skin-derived tenocyte-like cells for the treatment of patellar tendinopathy. Am J Sports Med. 2011; 39(3): 614–623, doi: 10.1177/0363546510387095, indexed in Pubmed: 21139155.
• 11. Connell D, Datir A, Alyas F, et al. Treatment of lateral epicondylitis using skin-derived tenocyte-like cells. Br J Sports Med. 2009; 43(4): 293–298, doi: 10.1136/bjsm.2008.056457, indexed in Pubmed: 19224912.
• 12. Connell DA, Ali KE, Ahmad M, et al. Ultrasound-guided autologous blood injection for tennis elbow. Skeletal Radiol. 2006; 35(6): 371–377, doi: 10.1007/s00256-006-0081-9, indexed in Pubmed: 16552606.
• 13. de Vos RJ, Weir A, van Schie HTM, et al. Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA. 2010; 303(2): 144–149, doi: 10.1001/jama.2009.1986, indexed in Pubmed: 20068208.
• 14. Evans CH. Cytokines and the role they play in the healing of ligaments and tendons. Sports Med. 1999; 28(2): 71–76, indexed in Pubmed: 10492026.
• 15. Fenwick SA, Hazleman BL, Riley GP. The vasculature and its role in the damaged and healing tendon. Arthritis Res. 2002; 4(4): 252–260, doi: 10.1186/ar416, indexed in Pubmed: 12106496.
• 16. Foster TE, Puskas BL, Mandelbaum BR, et al. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009; 37(11): 2259–2272, doi: 10.1177/0363546509349921, indexed in Pubmed: 19875361.
• 17. Franchi M, Fini M, Quaranta M, et al. Crimp morphology in relaxed and stretched rat Achilles tendon. J Anat. 2007; 210(1): 1–7, doi: 10.1111/j.1469-7580.2006.00666.x, indexed in Pubmed: 17229278.
• 18. Franchi M, Trirè A, Quaranta M, et al. Collagen structure of tendon relates to function. ScientificWorldJournal. 2007; 7: 404–420, doi: 10.1100/tsw.2007.92, indexed in Pubmed: 17450305.
• 19. Gelberman RH, Manske PR, Vande Berg JS, et al. Flexor tendon repair in vitro: a comparative histologic study of the rabbit, chicken, dog, and monkey. J Orthop Res. 1984; 2(1): 39–48, doi: 10.1002/jor.1100020107, indexed in Pubmed: 6491797.
• 20. Godwin EE, Young NJ, Dudhia J, et al. Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon. Equine Vet J. 2012; 44(1): 25–32, doi: 10.1111/j.2042-3306.2011.00363.x, indexed in Pubmed: 21615465.
• 21. Gruchow HW, Pelletier D. An epidemiologic study of tennis elbow. Incidence, recurrence, and effectiveness of prevention strategies. Am J Sports Med. 1979; 7(4): 234–238, doi: 10.1177/036354657900700405, indexed in Pubmed: 474862.
• 22. Grzelak P, Polguj M, Podgórski M, et al. Patellar ligament hypertrophy evaluated by magnetic resonance imaging in a group of professional weightlifters. Folia Morphol. 2012; 71(4): 240–244, indexed in Pubmed: 23197143.
• 23. Hall WD, Hurst JW, Walker HK. Clinical Methods: The History, Physical, and Laboratory Examinations. Chapter 72. 3rd edition. Boston, Butterworths 1990.
• 24. Henry B, Tomaszewski K, Pękala P, et al. Oblique incisions in hamstring tendon harvesting reduce iatrogenic injuries to the infrapatellar branch of the saphenous nerve. Knee Surgery, Sports Traumatol Arthrosc. 2017, doi: 10.1007/s00167-017-4590-y.
• 25. Ippolito E, Natali PG, Postacchini F, et al. Morphological, immunochemical, and biochemical study of rabbit achilles tendon at various ages. J Bone Joint Surg Am. 1980; 62(4): 583–598, indexed in Pubmed: 6991502.
• 26. Jozsa L, Kannus P, Balint JB, et al. Three-dimensional ultrastructure of human tendons. Acta Anat (Basel). 1991; 142(4): 306–312, indexed in Pubmed: 1801522.
• 27. Kallinen M, Markku A. Aging, physical activity and sports injuries. An overview of common sports injuries in the elderly. Sports Med. 1995; 20(1): 41–52, indexed in Pubmed: 7481278.
• 28. Kannus P, Józsa L, Natri A, et al. Effects of training, immobilization and remobilization on tendons. Scand J Med Sci Sports. 1997; 7(2): 67–71, indexed in Pubmed: 9211606.
• 29. Kannus P, Józsa L. Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients. J Bone Joint Surg Am. 1991; 73(10): 1507–1525, indexed in Pubmed: 1748700.
• 30. Kastelic J, Galeski A, Baer E. The multicomposite structure of tendon. Connect Tissue Res. 1978; 6(1): 11–23, indexed in Pubmed: 149646.
• 31. Kaux JF, Forthomme B, Goff CLe, et al. Current opinions on tendinopathy. J Sports Sci Med. 2011; 10(2): 238–253, indexed in Pubmed: 24149868.
• 32. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev. 2004; 84(2): 649–698, doi: 10.1152/physrev.00031.2003, indexed in Pubmed: 15044685.
• 33. Kvist M. Achilles tendon injuries in athletes. Ann Chir GynaecoL. 1991; 80(2): 188–201.
• 34. Langberg H, Skovgaard D, Petersen LJ, et al. Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans. J Physiol. 1999; 521 (Part 1): 299–306, indexed in Pubmed: 10562353.
• 35. Lewis T, Cook J. Fluoroquinolones and tendinopathy: a guide for athletes and sports clinicians and a systematic review of the literature. J Athl Train. 2014; 49(3): 422–427, doi: 10.4085/1062-6050-49.2.09, indexed in Pubmed: 24762232.
• 36. Lim JK, Hui J, Li Li, et al. Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthroscopy. 2004; 20(9): 899–910, doi: 10.1016/j.arthro.2004.06.035, indexed in Pubmed: 15525922.
• 37. Maffulli N, Khan KM, Puddu G. Overuse tendon conditions: time to change a confusing terminology. Arthroscopy. 1998; 14(8): 840–843, indexed in Pubmed: 9848596.
• 38. Magnusson SP, Beyer N, Abrahamsen H, et al. Increased cross-sectional area and reduced tensile stress of the Achilles tendon in elderly compared with young women. J Gerontol A Biol Sci Med Sci. 2003; 58(2): 123–127, indexed in Pubmed: 12586849.
• 39. Milgrom C, Schaffler M, Gilbert S, et al. Rotator-cuff changes in asymptomatic adults. The effect of age, hand dominance and gender. J Bone Joint Surg Br. 1995; 77(2): 296–298, indexed in Pubmed: 7706351.
• 40. Molloy TJ, de Bock CE, Wang Y, et al. The roles of growth factors in tendon and ligament healing. Sports Med. 2003; 33(5): 381–394, indexed in Pubmed: 12696985.
• 41. Murphy PG, Loitz BJ, Frank CB, et al. Influence of exogenous growth factors on the synthesis and secretion of collagen types I and III by explants of normal and healing rabbit ligaments. Biochem Cell Biol. 1994; 72(9-10): 403–409, indexed in Pubmed: 7605612.
• 42. Myllylä R, Salminen A, Peltonen L, et al. Collagen metabolism of mouse skeletal muscle during the repair of exercise injuries. Pflugers Arch. 1986; 407(1): 64–70, indexed in Pubmed: 3016636.
• 43. Narici MV, Maffulli N, Maganaris CN. Ageing of human muscles and tendons. Disabil Rehabil. 2008; 30(20-22): 1548–1554, doi: 10.1080/09638280701831058, indexed in Pubmed: 18608375.
• 44. Paavola M, Kannus P, Järvinen T, et al. Achilles tendinopathy. J Bone Joint Surg Am. 2002; 84(11): 2062–2076, doi: 10.2106/00004623-200211000-00024.
• 45. Pękala PA, Henry BM, Ochała A, et al. The twisted structure of the Achilles tendon unraveled: A detailed quantitative and qualitative anatomical investigation. Scand J Med Sci Sports. 2017; 27(12): 1705–1715, doi: 10.1111/sms.12835, indexed in Pubmed: 28139009.
• 46. Pusztaszeri MP, Seelentag W, Bosman FT. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem. 2006; 54(4): 385–395, doi: 10.1369/jhc.4A6514.2005, indexed in Pubmed: 16234507.
• 47. Reddy GK, Stehno-Bittel L, Enwemeka CS. Glycationinduced matrix stability in the rabbit achilles tendon. Arch Biochem Biophys. 2002; 399(2): 174–180, doi: 10.1006/abbi.2001.2747, indexed in Pubmed: 11888203.
• 48. Rees JD, Wilson AM, Wolman RL. Current concepts in the management of tendon disorders. Rheumatology (Oxford). 2006; 45(5): 508–521, doi: 10.1093/rheumatology/kel046, indexed in Pubmed: 16490749.
• 49. Riley G. Tendinopathy: from basic science to treatment. Nat Clin Pract Rheumatol. 2008; 4(2): 82–89, doi: 10.1038/ncprheum0700, indexed in Pubmed: 18235537.
• 50. Riley G. The pathogenesis of tendinopathy. A molecular perspective. Rheumatology (Oxford). 2004; 43(2): 131–142, doi: 10.1093/rheumatology/keg448, indexed in Pubmed: 12867575.
• 51. Rosager S, Aagaard P, Dyhre-Poulsen P, et al. Loaddisplacement properties of the human triceps surae aponeurosis and tendon in runners and non-runners. Scand J Med Sci Sports. 2002; 12(2): 90–98, indexed in Pubmed: 12121426.
• 52. Saini N, Kundnani V, Patni P, et al. Outcome of early active mobilization after flexor tendons repair in zones II-V in hand. Indian J Orthop. 2010; 44(3): 314–321, doi: 10.4103/0019-5413.65155, indexed in Pubmed: 20697486.
• 53. Selek O, Buluç L, Muezzinoğlu B, et al. Mesenchymal stem cell application improves tendon healing via anti-apoptotic effect (Animal study). Acta Orthop Traumatol Turc. 2014; 48(2): 187–195, doi: 10.3944/AOTT.2014.2985, indexed in Pubmed: 24747628.
• 54. Sharma P, Maffulli N, Sharma P, et al. Tendon injury and tendinopathy: healing and repair. J Bone Joint Surg Am. 2005; 87(1): 187–202, doi: 10.2106/JBJS.D.01850, indexed in Pubmed: 15634833.
• 55. Sharma P, Maffulli N. Biology of tendon injury: healing, modeling and remodeling. J Musculoskelet Neuronal Interact. 2006; 6(2): 181–190, indexed in Pubmed: 16849830.
• 56. Suresh SP, Ali KE, Jones H, et al. Medial epicondylitis: is ultrasound guided autologous blood injection an effective treatment? Br J Sports Med. 2006; 40(11): 935–9; discussion 939, doi: 10.1136/bjsm.2006.029983, indexed in Pubmed: 16990441.
• 57. Tuite DJ, Renström PA, O’Brien M. The aging tendon. Scand J Med Sci Sports. 1997; 7(2): 72–77, indexed in Pubmed: 9211607.
• 58. Vailas AC, Tipton CM, Laughlin HL, et al. Physical activity and hypophysectomy on the aerobic capacity of ligaments and tendons. J Appl Physiol Respir Environ Exerc Physiol. 1978; 44(4): 542–546, doi: 10.1152/jappl.1978.44.4.542, indexed in Pubmed: 205528.
• 59. Virchenko O, Aspenberg P. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop. 2006; 77(5): 806–812, doi: 10.1080/17453670610013033, indexed in Pubmed: 17068715.
• 60. Vogel KG, Ordög A, Pogány G, et al. Proteoglycans in the compressed region of human tibialis posterior tendon and in ligaments. J Orthop Res. 1993; 11(1): 68–77, doi: 10.1002/jor.1100110109, indexed in Pubmed: 8423522.
• 61. Waggett AD, Ralphs JR, Kwan AP, et al. Characterization of collagens and proteoglycans at the insertion of the human Achilles tendon. Matrix Biol. 1998; 16(8): 457–470, indexed in Pubmed: 9550263.
• 62. Xu Y, Murrell GAC. The basic science of tendinopathy. Clin Orthop Relat Res. 2008; 466(7): 1528–1538, doi: 10.1007/s11999-008-0286-4, indexed in Pubmed: 18478310.

Identyfikatory

DOI

10.5603/FM.a2018.0006