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2009 | 69 | 3 |
Tytuł artykułu

Changes in celebrospinal fluid concentration of oxidative stress markers during chemotherapy of acute lyphoblastic leukaemia in children

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In this study we advised question whether cerebrospinal fl uid oxidative stress markers are associated with neurotoxicity of chemotherapy of acute lymphoblastic leukaemia (ALL). Examination of 38 ALL patients revealed a statistically signifi cant increase in 8-isoprostane and decrease in total antioxidative capacity during the treatment. Dynamic analysis revealed a statistically signifi cant increase in isoprostane starting on the 59th day of the treatment when the levels were highest and remained raised during all the treatment course. The mean 8-isoprostane level at the diagnosis was 9.05 ± 5.12 pg/ml, and no correlation with initial leukocytosis, organomegaly and lactate dehydrogenase level was noted. Dynamic data analysis revealed a statistically signifi cant increase in 8-isoprostane on the 59th day of the treatment (24.85 ± 26.28) and at four points during consolidation phase (17.28 ± 8.09; 22.72 ± 21.79; 24.92 ± 22.74; 32.32 ± 26.85) as compared to its level at the diagnosis (P<0.01. The mean total antioxidative capacity level at the diagnosis was (203.98 ± 15.11 μmol/l). Dynamic data analysis revealed a statistically signifi cant decrease in total antioxidative capacity on the 59th day of the treatment (189.76 ± 4.64) and at one point during consolidation phase (188.29 ± 8.46) as compared to its level at the diagnosis (P<0.05). The study suggests that standard ALL treatment may cause neurotoxicity by oxidative stress.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.318
Twórcy
autor
  • Department of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland
  • Department of Pediatric Oncology, Medical University of Bialystok, Bialystok, Poland
autor
  • Department of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland
  • Department of Pediatric Oncology, Medical University of Bialystok, Bialystok, Poland
autor
  • Department of Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-12ed72b0-7c1b-4300-9bc1-5e2fe76da739
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