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Liczba wyników
2009 | 69 | 3 |
Tytuł artykułu

Inhibition of infiltration and activation of brain macrophages underlies antitumor activity of systemically administered cyclosporin A.

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Malignant glioblastomas are characterized by infi ltration of tumour tissue with brain macrophages that contribute to tumour progression through release a variety of growth factors, cytokines/ chemokines supporting tumor growth, invasion and the immune system evasion. Thus targeting of cytokine production, infi ltration and activation of macrophages may be a novel antitumor strategy. In the present study, we investigated an effectiveness and molecular mechanisms mediating antitumor effects of CsA in the murine glioma model. EGFP-GL261 glioma cells were injected into the striatum of C57BL/6 mice and tumor-bearing mice received CsA (2 or 10 mg/kg/i.p.) every 2 days from 2nd or 8th day after implantation. CsA-treated mice had signifi cantly smaller tumors than control mice. When the treatment was postponed to 8th day, only the higher dose of CsA was effective. CsA-treated mice showed a diminished number of tumor-infi ltrating, amoeboid brain macrophages. TUNEL staining revealed a DNA fragmentation mostly within infi ltrating macrophages after CsA treatment. At concentrations <10 μM CsA did not affect proliferation or viability of cultured glioma cells. Elevated IL-10 and GM-CSF levels were found in tumor-bearing hemisphere in comparison to naive controls and CsA treatment reduced signifi cantly cytokine levels. Our fi ndings demonstrate that CsA-induced decrease of cytokine production, infi ltration and activation of macrophages results in reduction of glioma growth and progression.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.346
Twórcy
  • Department of Cell Biology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Department of Cell Biology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Department of Cell Biology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Department of Cell Biology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Department of Cell Biology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-11f8cab4-8f8f-4f7d-82b7-e76e40f34ada
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