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2011 | 29 | 4 |
Tytuł artykułu

Bovine milk proteins as the source of bioactive peptides influencing the consumers’ immune - a review

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Języki publikacji
The present review describes selected peptides derived from bovine milk proteins and demonstrates their effect on the human immune system. Apart from their obvious nutritive value milk proteins and products of their degradation (peptides) have multiple biological functions. Bovine milk,fermented milk drinks and cheeses are the most abundant sources of biologically active peptides. One of the primary functions of milk is to protect the health of a newborn organism by the virtue of the fact that milk contains many proteins, which exhibit bacteriostatic and bactericidal properties in their intact form. Ingestion of bovine milk by humans causes that bioactive peptides are evoked from delivered proteins during the course of digestion. They possess not only immunomodulatory,but also antibacterial, antiviral and antifungal properties.
Opis fizyczny
  • Department of Commodity Science and Processing of Raw Animal Materials, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
  • Department of Commodity Science and Processing of Raw Animal Materials, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
  • Department of Commodity Science and Processing of Raw Animal Materials, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
  • Department of Commodity Science and Processing of Raw Animal Materials, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
  • APPELMELK B.J., AN Y.-Q., GEERST M., THIJS B.G., DEBOER H.A., MCCLAREN D.M.,DEGRAAFF J., NUIJENS J.H., 1994 – Lactoferrin is a lipid A-binding protein. Infection and Immunity 62, 2628- 2632.
  • ATANASOVA J., IVANOVA I., 2010 – Antibacterial peptides from goat and sheep milk proteins.Biotechnology & Biotechnological Equipment 24 (2), 1799-1803.
  • BAGNICKA E., STRZAŁKOWSKA N., JÓŹWIK A., KRZYŻEWSKI J., HORBAŃCZUK J.O.,ZWIERZCHOWSKI L.,2010 - Defensins in farm animals, their expression and polymorphism. Acta Biochimica Polonica 2034, 57(4), 487-497.
  • BARŁOWSKA J., LITWIŃCZUK A., 2008 – Właściwości funkcjonalne białek mleka krowiego.Przegląd Hodowlany 5, 26-28.
  • BECHINGER B., 1997 – Structure and functions of channel forming peptides: magainins, cecropins, melittin and alamethicin. Journal of Membrane Biology 156, 197-211.
  • BELLAMY W., TAKASE M., YAMAUCHI K., WAKABAYASHI H., KAWASE K., TOMITA M.,1992 – Identification of the bactericidal domain of lactoferrin. Biochimica et Biophysica Acta –Protein Structure and Molecular Enzymology 1121(1-2), 130-136.
  • BRODGEN K.A., 2005 – Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria.Nature Reviews Microbiology 3, 238-250.
  • BRODY, E.P., 2000 – Biological activities of bovine glycomacropeptide. British Journal of Nutrition 84, 39-46.
  • CLARE D.A., CATIGNANI G.L., SWAISGOOD H.E., 2003 – Biodefense properties of milk: the role of antimicrobial proteins and peptides. Current Pharmaceutical Design 29, 1239-1255.
  • CLARE D.A., SWAISGOOD H.E., 2000 – Bioactive Milk Peptides: A Prospectus. Journal of Dairy Science 83, 1187-1195.
  • DASHPER S.G., O’BRIEN-SIMPSON N.M., CROSS K.J., PAOLINI R.A, HOFFMANN B.,CATMULL D.V., MALKOSKI M., REYNOLDS E.C., 2005 – Divalent metal cations increase the activity of the antimicrobial peptide kappacin. Antimicrobial Agents and Chemotherapy 49, 2322-2328.
  • EBRINGER L., FERENČÍK M., KRAJČOVIČ J., 2008 – Beneficial health effects of milk and fermented dairy products. Folia Microbiologica 53(5), 378-394.
  • FAO/WHO Food and Agriculture Organization of the United Nations/World Health Organization,2008 – Enterobacter sakazakii (Cronobacter spp.) in powdered follow-up formulae. Microbiological Risk Assessment Series, 15, Rome.
  • FARNAUD S., EVANS, R.W., 2003 – Lactoferrin – a multifunctional protein with antimicrobial properties. Molecular Immunology 40, 395-405.
  • FIAT A.M., MIGLIORE D., JOLLČS P., 1993 – Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunostimulating activities. Journal of Dairy Science 76(1), 301-310.
  • GAGNAIRE V., BOUTROU R., LÉONIL J., 2001 – How can the peptides produced from Emmental cheese give some insights on the structural features of the paracasein matrix? International Dairy Journal 11, 449-454.
  • GIFFORD J.L., HUNTER H.N., VOGEL H.J., 2005 – Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cellular and Molecular Life Sciences 62, 2588-2598.
  • GOBBETTI M, FERRANTI P, SMACCHI E, GOFFREDI F, ADDEO F., 2000 – Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4. Applied Environmental Microbiology 66, 3898-3904.
  • HANCOCK R.E., LEHRER R., 1998 – Cationic peptides: a new source of antibiotics. Trends in Biotechnology 16, 82-88.
  • HAQUE E., CHAND R., 2008 – Antihypertensive and antimicrobial bioactive peptides from milk proteins. European Food Research and Technology 227, 7-15.
  • HAUG A., HŘSTMARK A.T., HARSTAD O.M., 2007a – Bovine milk in human nutrition. Lipids in Health and Disease 6, 25-41.
  • Haug B.E., Strřm M.B., Svendsen J.S.M., 2007b – The medicinal chemistry of short lactoferricin-based antibacterial peptides. Current Medicinal Chemistry 14, 1-18.
  • HAYES M., ROSS R.P., FITZGERALD G.F., STANTON C., 2007 – Putting microbes to work:Dairy fermentation, cell factories and bioactive peptides. Part I: Overview. Biotechnology Journal 2, 426-434.
  • HAYES M., ROSS R.P., FITZGERALD G.F., HILL C., STANTON C., 2005 – Casein-derived antimicrobial peptides generated by Lactobacillus acidophilus DPC6026. Applied Environmental Microbiology 72, 2260-2264.
  • HOST A., HALKEN S., 2004 – Hypoallergenic formulas – when, to whom and how long: after more than 15 years we know the right indication! Allergy 59, 45-52.
  • KAMAU S.M., CHEISON S.CH., CHEN W., LIU X.M., LU R.R., 2010 – Alpha-Lactalbumin: its production technologies and bioactive peptides. Comprehensive Reviews in Food Science and Food Safety 9, 197-212.
  • KITTS D.D., WEILER K., 2003 – Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Current Pharmaceutical Design 9, 1309-1323.
  • KORHONEN H., PIHLANTO A., 2006 – Bioactive peptides: Production and functionality.International Dairy Journal 16, 945-960.
  • KORPYSA-DZIRBA W., ROLA J.G., OSEK J., 2007 – Enterobacter sakazakii – zagrożenie mikrobiologiczne w żywności (Enterobacter sakazakii – a microbiological threat in food). In Polish,summary in English. Medycyna Weterynaryjna 63(11), 1277-1280.
  • KRÓL J., BRODZIAK A., LITWIŃCZUK Z., SZWAJKOWSKA M., 2011 – Wykorzystanie białek serwatkowych w promocji zdrowia (Whey protein utilization in health promotion). In Polish,summary in English. Żywienie człowieka i metabolizm XXXVIII(1), 36-45.
  • KRÓL J., LITWIŃCZUK A., ZARAJCZYK A., LITWIŃCZUK Z., 2008 – Alfa-laktoalbumina I beta-laktoglobulina jako związki biologicznie czynne frakcji białkowej mleka (Alpha-lactalbumin and beta-lactoglobulin as biologically active substances in proteinous fraction of milk). In Polish,summary in English. Medycyna Weterynaryjna 64, 1375-1378.
  • LAHOV E., REGELSON W., 1996 – Antibacterial and immunostimulating casein-derived substances from milk: caseicidin, isracidin peptides. Food and Chemical Toxicology 34, 131-145.
  • LeBLANC J., FLISS I., MATAR C., 2004 – Induction of a humoral immune response following an Escherichia coli O157:H7 infection with an immunomodulatory peptidic fraction derived from Lactobacillus helveticus-fermented milk. Clinical and Diagnostic Laboratory Immunology 11,1171-1181.
  • LeBLANC J.G., MATAR C., VALDEZ J.C., LeBLANC J., PERDIGON G., 2002 – Immunomodulating effects of peptidic fractions issued from milk fermented with Lactobacillus helveticus. Journal of Dairy Science 85, 2733-2742.
  • LITWIŃCZUK Z., KRÓL J., BRODZIAK A., BARŁOWSKA J., 2011 – Changes of protein content and its fractions in bovine milk from different cow breeds subject to somatic cell count. Journal of Dairy Science 94(12), 684-691.
  • LOPEZ-EXPOSITO I., RECIO I. 2008 – Protective effect of milk peptides: antibacterial and antitumor properties. In: Bioactive Components of Milk. Advances in Experimental Medicine and Biology 606, 271-294.
  • LOSITO I., CARBONARA T., DE BARI M.D., GOBBETTI M., PALMISANO, F., RIZZELLO C.G., ZAMBONIN P.G., 2006 – Identification of peptides in antimicrobial fractions of cheese extracts by electrospray ionization ion trap mass spectrometry coupled to a two-dimensional liquid chromatographic separation. Rapid Communications in Mass Spectrometry 20, 447-455.
  • MALACZEWSKA J., ROTKIEWICZ Z., 2007 – Laktoferyna – białko multipotencjalne (Lactoferrin – multipotential protein). In Polish, summary in English. Medycyna Weterynaryjna 63(2), 136-139.
  • MALKOSKI M., DASHPER S.G., O’BRIEN-SIMPSON N.M., TALBO G.H., MACRIS M.,CROSS K.J., REYNOLDS, E.C., 2001 – Kappacin, a novel antibacterial peptide from bovine milk.Antimicrobial Agents and Chemotherapy 45, 2309-2315.
  • MICHAELIDOU A.M., 2008 – Factors influencing nutritional and health profile of milk and milk products. Small Ruminant Research 79, 42-50.
  • MÖLLER N.P., SCHOLZ-AHRENS K.E., ROOS N., SCHREZENMEIR J., 2008 – Bioactive peptides and proteins from foods: indication for health effects. European Journal of Nutrition 47,171-182.
  • NEURATH A.R., DEBNATH A.K., STRICK N., LI Y.Y., LIN K., JIANG S., 1997a – 3-hydroxyphthaloyl-beta-lactoglobulin. 1. Optimization of production and comparison with other compounds considered for chemoprophylaxis of mucosally transmitted human immunodeficiency virus type 1. Antiviral Chemistry & Chemotherapy 8, 131-139.
  • NEURATH A.R., DEBNATH A.K., STRICK N., LI Y.Y., LIN K., JIANG S., 1997b – 3-hydroxyphthaloyl-beta - lactoglobulin. 2. Anti - human immunodeficiency virus type 1 activity in in vitro environments relevant to prevention of sexual transmission of the virus. Antiviral Chemistry and Chemotherapy 8, 141-148.
  • NIBBERING P.H., RAVENSBERGEN E., WELLING M.M., VAN BERKEL L.A., VAN BERKEL P.H.C., PAUWELS E.K.J., NUIJENS J.H., 2001 – Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic- resistant bacteria. Infection and Immunity 69, 1469-1476.
  • NORBERG S., O’CONNOR P.M., STANTON C., ROSS R.P., HILL C., FITZGERALD G.F.,COTTER P.D., 2011 – Altering the composition of caseicins A and B as a Means of Determining the Contribution of Specific Residues to Antimicrobial Activity. Applied and Environmental Microbiology 77, 2496-2501.
  • OEVERMANN A., ENGELS M., THOMAS U., PELLEGRINI A., 2003 – The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification. Antiviral Research 59, 23-33.
  • Oo T.Z., Cole N., Garthwaite L., Mark D., Willcox P., Zhu H., 2010 – Evaluation of synergistic activity of bovine lactoferricin with antibiotics in corneal infection. Journal of Antimicrobial Chemotherapy 65, 1243-1251.
  • OONAKA K., FURUHATA K., HARA M., FUKUYAMA M., 2010 – Powder Infant Formula contaminated with Enterobacter Sakazakii. Japanese Journal of Infectious Disease 63, 103-107.
  • PAN Y., ROWNEY M., GUO P., HOBMAN P., 2007 – Biological properties of lactoferrin: an overview. Australian Journal of Dairy Technology 62, 31-42.
  • PELLEGRINI A., DETTLING C., THOMAS U., HUNZIKER P., 2001 – Isolation and characterization of four bactericidal domains in the bovine beta-lactoglobulin. Biochimica et Biophysica Acta.General Subjects, 1526, 131-140.
  • PELLEGRINI A., SCHUMACHER S., STEPHAN R., 2003 – In vitro activity of various antimicrobial peptides developed from the bactericidal domains of lysozyme and beta-lactoglobulin with respect to Listeria monocytogenes, Escherichia coli O157, Salmonella spp. and Staphylococcus aureus. Archiv fuer Lebensmittelhygiene 54, 34-36.
  • PELLEGRINI A., THOMAS U., BRAMAZ N., HUNZIKER P., VON FELLENBERG R., 1999 – Isolation and identification of three bactericidal domains in the bovine alpha-lactalbumin molecule.Biochimica et Biophysica Acta. General Subjects, 1426, 439-448.
  • Picariello G., Ferranti P., Fierroa O., Mamonea G., Cairaa S., Di Luccia A.,Monica S., Addeon F., 2010 – Peptides surviving the simulated gastrointestinal digestion of milk proteins: Biological and toxicological implications. Journal of Chromatography B 878, 295-308.
  • PRIOULT G., PECQUET S., FLISS I., 2004 – Stimulation of interleukin-10 production by acidic beta-lactoglobulin-derived peptides hydrolyzed with Lactobacillus paracasei NCC2461 peptidases.Clinical and Diagnostic Laboratory Immunology 11, 266-271.
  • PRITCHARD S.R., PHILLIPS M., KAILASAPATHY K., 2010. Identification of bioactive peptides in commercial Cheddar cheese. Food Research International 43, 1545-1548.
  • Rachid M., Matar C., Duarte J., Perdigon G., 2006 – Effect of milk fermented with a Lactobacillus helveticus R389 (+) proteolytic strain on the immune system and on the growth of 471 breast cancer cells in mice. FEMS Immunology and Medical Microbiology 47, 242-253.
  • RECIO I., VISSER S., 1999 – Two ion-exchange methods for the isolation of antibacterial peptides from lactoferrin – in situ enzymatic hydrolysis on an ion-exchange membrane. Journal of Chromatography 831, 191–201.
  • RIZZELLO C.G., LOSITO I., GOBBETTI M., CARBONARA T., DE BARI M.D., ZAMBONIN P.G., 2005 – Antibacterial activities of peptides from the water-soluble extracts of Italian cheese varieties. Journal of Dairy Science 88, 2348-2360.
  • Sayer , G.P., Britt , H., Lahov , E., Regelson , W., 1996 – Antibacterial and immunostimulating casein-derived substances from milk: casecidin, isracidin peptides. Food and Chemical Toxicology 34,131-145.
  • Seppo L., Jauhiainen T., Poussa T., Korpela R., 2003 – A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. The American Journal of Clinical Nutrition 77, 326-330.
  • Sieber R., Bütikofer U., Egger Ch., Portmann R., Walther B., Wechsler D.,2010 – ACE-inhibitory activity and ACE-inhibiting peptides in different cheese varieties. Dairy Science and Technology 90, 47-73.
  • Silva S.V., Malcata F.X., 2005 – Caseins as source of bioactive peptides. International Dairy Journal 15, 1-15.
  • SHORTT C., O’BRIEN J., 2004 – Handbook of Functional Dairy Products. Published by CRC PRESS LLC 2004, USA.
  • Srinivas S., Prakash V., 2010 – Bioactive peptides from bovine milk a-casein: isolation,characterization and multifunctional properties. International Journal of Peptide Research and Therapeutics 16, 7-15.
  • TAHA S., MEHREZ M., SITOHY M., ABOU DAWOOD A.G., ABD-EL HAMID M., KILANY, W.,2010 – Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1). Virology Journal 7(1), 330-334.
  • TOMITA M., WAKABAYASHI H., YAMAUCHI K., TERAGUCHI S., HAYASAWA H., 2001 – Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochemistry and Cell Biology 80, 109-112.
  • van der Kraan M.I.A, Nazmi K., Teeken A., Groenink J., van ‘t Hof W., Veerman E.C., Bolscher J.G., Nieuw Amerongen A.V., 2005 – Lactoferrampin, an antimicrobial peptide of bovine lactoferrin, exerts its candidacidal activity by a cluster of positively charged residues at the C-terminus in combination with a helix-facilitating N-terminal part. The Journal of Biological Chemistry 386, 137-142.
  • VAN DER KRAAN M.I.A., GROENINK J., NAZMI K., VEERMAN E.C.I., BOLSCHER J.G.M.,NIEUW AMERONGEN A.V., - 2004. Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin. Peptides 25, 177-183.
  • VERMEIRSSEN V., VAN CAMP J., VERSTRAETE W., 2004 – Bioavailability of angiotensin I converting enzyme inhibitory peptides. British Journal of Nutrition 92, 357-366.
  • WALTHER B., SCHMID A., SIEBER R., WEHRMÜLLER K., 2008 – Cheese in nutrition and health. Dairy Science and Technology 88, 389-405
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