Structural neuroplasticity induced by melatonin in entorhinal neurons of rats exposed to toluene inhalation

• Autorzy: Pascual R. , Bustamante C.
• Języki publikacji: EN

Abstrakty

EN

Several clinical studies have shown that abusing volatile solvents, mainly toluene, produces neurological, neuropathological and neuropsychiatry disorders. Symptoms of these disorders include loss in impulse control, distractibility and memory deficits, which are associated with mild brain atrophy. The entorhinal cortex is critically involved in mnemonic processes, and memory disorders are the major symptom detected in chronic solvent abusers. Therefore, in the present study, we evaluated (1) whether the entorhinal neuronal morphology was impaired by subchronic toluene exposure and (2) if melatonin protected the neuronal cytoarchitecture, as has been demonstrated in neocortical neurons. Consistent with our previous findings, the present study indicates that the entorhinal cell dendritic arborization was significantly reduced in toluene- exposed animals, and melatonin administration significantly rescued the reduced dendritic branching induced by toluene neurotoxicity.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 4
• Opis fizyczny: p.541-547,fig.,ref.

Twórcy

autor

Pascual R.

• Laboratorio de Neurociencias, Escuela de Kinesiologia, Facultad de Ciencias, Pontificia Univesidad Catolica de Valparaiso, Avenida Brasil 2950, Valparaiso, Chile

autor

Bustamante C.

• Laboratorio de Neurociencias, Escuela de Kinesiologia, Facultad de Ciencias, Pontificia Univesidad Catolica de Valparaiso, Avenida Brasil 2950, Valparaiso, Chile

Bibliografia

• Aydin K, Kircan S, Sarwar S, Okur O, Balaban E (2009) Smaller gray matter volume in frontal and parietal corti­ces of solvent abusers correlates with cognitive deficits. Am J Neuroradiol 30: 1922-1928.
• Bale AS, Tu Y, Carpenter-Hyland EP, Chandler LJ, Woodward JJ (2005) Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. Neuroscience 130: 197-206.
• Baydas G, Reiter RJ, Nedzvetskii VS, Yasar A, Tuzcu M, Ozveren F, Canatan H (2003) Melatonin protects the cen­tral nervous system of rats against toluene-containing thinner intoxication by reducing reacting gliosis. Toxicol Lett 137: 169-174.
• Benitez-King G (2006) Melatonin as a cytoskeletal modula­tor: implications for cell physiology and disease. J Pineal Res 40: 1-9.
• Bowen SE, McDonald P (2009) Abuse pattern of toluene exposure alters mouse behavior in a waiting-for-reward operant task. Neurotoxicol Teratol 31: 18-25.
• Carloni S, Perrone S, Buonocore G, Longini L, Proietti F, Balduini W (2008) Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats. J Pineal Res 44: 157-164.
• Coleman PD, Riesen AH (1968) Environmental effects on cortical dendritic fields. I. Rearing in the dark. J Anat 102: 363-374.
• Copur M, Turkcan A, Erdogmus M (2005) Substance abuse, conduct disorder and crime: assessment in a juvenile detention house in Istanbul, Turkey. Psychiatry Clin Neurosci 59: 151-154.
• Coutureau E, Di Scala G (2007) Entorhinal cortex and cog­nition. Prog Neuropsychopharmacol Biol Psychiatry 33: 753-761.
• Chouaniere D, Wild P, Fontana JM, Hery M, Fournier M, Baudin V, Subra I, Rouselle D, Toamain JP, Ardiot MR (2002) Neurobehavioral disturbances arising from occu­pational toluene exposure. Am J Ind Med 41: 77-88.
• Edelfors S, Hass U, Hougaard KS (2002) Changes in mark­ers of oxidative stress and membrane properties in synap- tosomes from rats exposed prenatally to toluene. Pharmacol Toxicol 90: 26-31.
• Filley CM, Halliday W, Kleinschmidt-DeMasters BK (2004) The effects of toluene on the central nervous system. J Neuropathol Exp Neurol 63: 1-12.
• Furio AM, Brusco LI, Cardinali DP (2007) Possible thera­peutic value of melatonin in mild cognitive impairment: a retrospective study. J Pineal Res 43: 404-409.
• Garcia-Chavez D, Gonzalez-Burgos I, Letechipia-Vallejo G, Lopez-Loeza E, Morali G, Cervantes M (2008) Long- term evaluation of cytoarchitectonic characteristics of prefrontal cortex pyramidal neurons following global cerebral ischemia and neuroprotective melatonin treat­ment, in rats. Neurosci Lett 448: 148-152.
• González-Burgos I, Letechipía-Vallejo G, López-Loeza E, Moralí G, Cervantes M (2007) Long-term study of den­dritic spines from hippocampal CA2 pyramidal cells, after neuroprotective melatonin treatment following glob­al ischemia in rats. Neurosci Lett 423: 162-166.
• Gotohda T, Tokunaga I, Kubo S, Morita K, Kitamura O, Eguchi A (2000) Effect of toluene inhalation on astro- cytes and neurotrophic factor in rat brain. Forensic Sci Int 113: 233-238.
• Greenough WT, Volkmar FR, Juraska JM (1973) Effects of rearing complexity on dendritic branching in frontolateral and temporal cortex of the rat. Exp Neurol 41: 371-378.
• Hinman DJ (1987) Biphasic dose-response relationship for effects of toluene inhalation on locomotor activity. Pharmacol Biochem Behav 26: 65-69.
• Hormes JT, Filley ChM, Rosenberg NL (1986) Neurologic sequelae of chronic solvent vapor abuse. Neurology 36: 698-702.
• Imbesi M, Uz T, Dzitoyeva S, Manev H (2008) Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells. Neurosci Lett 439: 34-36.
• Konur S, Ghosh A (2005) Calcium signaling and the control of dendritic development. Neuron 46: 401-405.
• Korbo L, Ladefoged O, Lam HR, Ostergaard G, West MJ, Arlien-Soborg P (1996) Neuronal loss in hippocampus in rats exposed to toluene. Neurotoxicology 17: 359-366.
• Kucuk NO, Killic EO, Ibis E, Aysev A, Gencoglu EA, Aras G, Soylu A, Erbay G (2000) Brain SPECT findings in long-term inhalant abuse. Nucl Med Commun 21: 769­773.
• Lazar RB, Ho SU, Melen O, Daghestani AN (1983) Multifocal central nervous system damage caused by toluene abuse. Neurology 33: 1337-1340.
• Lei Z, Ruan Y, Yang AN, Xu ZC (2006) NMDA receptor dendritic plasticity in cortical cultures after oxygen-glu­cose deprivation. Neurosci Lett 407: 224-229.
• Letechipía-Vallejo G, López-Loeza E, Espinoza-González V, González-Burgos I, Olvera-Cortés ME, Moralí G, Cervantes M (2007) Long-term morphological and func­tional evaluation of the neuroprotective effects of post- ischemic treatment with melatonin in rats. J Pineal Res 42: 139-146.
• McAllister AK, Katz LC, Lo DC (1999) Neurotrophins and synaptic plasticity. Annu Rev Neurosci 22: 295-318.
• Pascual R, Salgado C, Viancos L, Figueroa HL (1996) Effects of subchronic inhalation of vaporized plastic cement on exploratory behavior and Purkinje cell differ­entiation in the rat. J Toxicol Environ Health 49: 525­532.
• Pascual R, Zamora-León S, Pérez N, Rojas T, Rojo A, Salinas MJ, Reyes A, Bustamante C (2010) Melatonin ameliorates neocortical neuronal dendritic impairment induced by toluene inhalation in the rat. Exp Toxicol Pathol doi: 10.1016/j.etp 201003.006.
• Paxinos G, Watson Ch (1998) The rat brain in stereotaxic coordinates. Academic Press, San Diego, CA.
• Petit TL, LeBoutillier JC, Gregorio A, Libstug H (1988) The pattern of dendritic development in the cerebral cortex of the rat. Brain Res 469: 209-219.
• Seo HS, Yang M, Song MS, Kim JS, Kim SH, Kim JC, Kim H, Shin T, Wang H, Moon C (2010) Toluene inhibit hip- pocampal neurogenesis in adult mice. Pharmacol Biochem Behav 94: 588-594.
• Shelton KL (2007) Inhaled toluene vapor as a discriminative stimulus. Behav Pharmacol 18: 219-229.
• Shelton KL, Slavova-Hernandez G (2009) Characterization of inhaled toluene drug discrimination in mice: effect of exposure conditions and route of administration. Pharmacol Biochem Behav 92: 614-620.
• Sholl DA (1953) Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 87: 387-407.
• Thiesen FV, Noto AR, Barros HM (2007) Laboratory diag­nosis of toluene-base inhalants abuse. Clin Toxicol 45: 557-562.
• Uzun N, Kendirli Y (2005) Clinical, socio-demographic, neurophysiological and neuropsychiatric evaluation of children with volatile substance addiction. Child Health Care Dev 31: 425-432.
• Walkley SU, Zerbas M, Wiseman S (2000) Gangliosides as modulators of dendritogenesis in normal and storage disease-affected pyramidal neurons. Cereb Cortex 10: 1028-1037.

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