Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures

• Autorzy: Zandi N. , Zaniani N.R. , Maghimi A. , Roohbakhsh A.
• Języki publikacji: EN

Abstrakty

EN

Epilepsy is a life-threatening disorder that is marked by recurrent seizures. Febrile seizure is a common neurological disorder observed in neonates. In many cases, reducing body temperature can prevent febrile seizure. Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cation channel that is involved in body thermoregulation. It was reported that M8-B, a TRPM8 antagonist, can reduce body temperature. Thus, we aimed to investigate the effect of M8-B on different experimental seizure models. Eight-day-old male Wistar rat pups were used for induction of febrile seizure. M8-B and diazepam were injected intraperitoneally. The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured. In addition, different groups of mice were pretreated with M8-B and received a convulsant dose of pentylenetetrazol (PTZ). Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured. Furthermore, the effect of M8-B on electroshock-induced seizures was also investigated and hindlimb extension time was measured. The results showed that M8-B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect. It also induced a significant anticonvulsant effect in PTZ - but not electroshock-induced convulsions. M8-B showed anticonvulsant effects in both febrile- and PTZ-induced seizures. M8-B had a hypothermic effect with significant protective effects on febrile- and PTZ-induced seizures; however, it did not produce similarly protective effects on seizures induced by electroshock.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2019
• Tom: 79
• Numer: 1
• Opis fizyczny: p.86-91,fig.,ref.

Twórcy

autor

Zandi N.

• Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

autor

Zaniani N.R.

• Rayan Center for Neuroscience and Behavior, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

autor

Maghimi A.

• Rayan Center for Neuroscience and Behavior, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

autor

Roohbakhsh A.

• Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

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Identyfikatory

DOI

10.21307/ane‑2019‑007