Systemic neurotransplantation-systematic review

• Autorzy: Janowski M. , Date I.
• Języki publikacji: EN

Abstrakty

EN

Systemic neurotransplantation (SNT) was introduced to laboratory as a new route of cell delivery in minimal invasive fashion. The aim of the systematic review was to evaluate the effect of SNT and to explore the variables infl uencing the outcome. PubMed library was searched and 60 articles utilizing SNT approach were found and subjected to analysis. Morphological (lesion size), behavioral and molecular (such as: neurogenesis, immunomodulation) effects were the primary measures of outcome. For comparison between experimental and control groups means, standard deviations and animal numbers were used. It was calculated according to Hedges g formula and expressed as an effect size and standard error (SE). For setting together the effect sizes from particular studies were weighted by the inverse variance. Then the effect size of the group of studies was calculated by method of fi xed effect model and expressed as weighted mean and confi dence interval (CI) which was set at 95%. SNT exerted large positive infl uence on outcomes in animal models of neurological disorders. Morphological effect was weaker, and molecular effect was stronger than behavioral effect. The explanation of this phenomenon may be that grafted cells cause not only the reduction of lesion size, but also enhance the function of the remained, macroscopically non-damaged brain by molecular means such as apoptosis inhibition, enhancement of cell proliferation, growth factor expression etc. Species and tissue compatibility between donor and recipient of SNT facilitates neurological recovery. In contrast, immunosuppression decreases therapeutic effect. Among several correlates only cell dosage infl uences positively outcomes. Our analysis should help to design clinical trials. Supported by MSHE grant No 2PO5A05430

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 1
• Opis fizyczny: p.106-107

Twórcy

autor

Janowski M.

• NeuroRepair Department, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw Poland

autor

Date I.

• Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan