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2016 | 19 | 3 |

Tytuł artykułu

7S fragment of type iv collagen as a serum marker of canine liver fibrosis

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of this study was to assess whether the serum levels of the 7S fragment of type IV collagen may aid in diagnosing liver fibrosis in dogs. The study was carried out on 20 dogs with liver disease. Serum levels of the 7S fragment of type IV collagen were measured in all dogs. The analysis showed that healthy dogs and dogs with type 1, 2 and 3 liver fibrosis had low serum concentrations of the 7S fragment of type IV collagen compared to dogs with type 4 liver fibrosis. The study revealed that the assessment of serum levels of the 7S fragment of type IV collagen is useful in the diagnosis of advanced liver fibrosis and cirrhosis.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

19

Numer

3

Opis fizyczny

p.647-649,ref.

Twórcy

  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland
autor
  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Diseases with Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland

Bibliografia

  • Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275: 2247-2250.
  • Goodman ZD (2007) Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol 47: 598-607.
  • Park JH, Park CK, Kim ES, Park SY, Jo CM, Tak WY, Kweon YO, Kim SK, Choi YW (2003) The diagnostic value of serum hyaluronic acid, 7S domain of type IV collagen and AST/ALT ratio as markers of hepatic fibrosis in chronic hepatitis B and cirrhosis patients. Taehan Kan Hakhoe Chi 9: 79-88.
  • Suou T, Yamada S, Hosho K, Yoshikawa N, Kawasaki H (1996) Relationship between serum and hepatic 7S fragments of IV collagen in chronic liver disease. Hepatology 23: 1154-1158.
  • Tsutsumi M, Urashima S, Matsuda Y, Takase S, Takada A (1993) Changes in type IV collagen content in livers of patients with alcoholic liver disease. Hepatology 17: 820-827.
  • Yamada S, Kishimoto Y, Suou T, Kawasaki H, Horie Y (1992) Heterogeneity of antigens related to 7S domain of type IV collagen in serum: application to patients with chronic liver disease. Clin Chim Acta 212: 73-78.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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